Collagen–poly glycolic acid hybrid matrix with basic fibroblast growth factor accelerated angiogenesis and granulation tissue formation in diabetic mice

Abstract

Because poor skin wound healing associated with diabetes is thought to be partly a result from impaired angiogenesis, treatments that improve angiogenesis could have important clinical applications. We herein report the effects of novel developed material, collagen-poly glycolic acid fiber hybrid matrix, being used together with basic fibroblast growth factor to promote wound healing of full-thickness skin defects on the back of type 2 diabetic Lepr(db) mice. Our data indicates that this therapeutic approach markedly promotes angiogenesis and granulation tissue formation in comparison with other conditions 14 days after wounding.

Promotion of skin regeneration in diabetic rats by electrospun core-sheath fibers loaded with basic fibroblast growth factor

“…Various systems for the topical delivery of GFs-containing gels around the lesions were adopted to improve the wound recovery, including crosslinked chitosan hydrogel [15], gelatin microspheres [16], gelatin sponge [17], and glycosaminoglycan hydrogel [18]. The naturally derived polymers are compromised by rapid absorption and poor mechanical strength, and are usually accompanied by impaired angiogenesis that prevents graft fixation [19]. We assumed that the gels cannot hold GFs very well, and the quick releasing may be predominantly responsible for the mild improvement without dose-dependent therapeutic effects.…”

Silver Nanoparticles Mediate Differential Responses in Keratinocytes and Fibroblasts during Skin Wound Healing

“…[1] Re-epithelialization, a crucial process during the early phase of wound healing, occurs not only by the migration and proliferation of keratinocytes in the epidermal layer of skin from the wound edge, but also by the differentiation of stem cells residing in the bulge of hair follicles. [2] Rapid re-epithelialization after wounding provides an optimum environment for healing, including a scaffold of cells and various growth factors, which are indispensable in the wound-healing process. Along with re-epithelialization, wound contraction is another important process in the early phase of wound healing.…”

Silver Nanoparticles as Real Topical Bullets for Wound Healing

“…7 A crucial process during the early stage of wound healing, reepithelialization, occurs, not only by the migration and proliferation of keratinocytes in the epidermal layer of the skin from the wound edge, but also by differentiation of stem cells residing in the bulge of the hair follicle. 8 The vital goal for wound healing is rapid recovery with little scarring and maximal function. Rapid reepithelialization provides a more favorable environment, such as a scaffold of cells and various growth factors, which is essential in wound treatment.…”