Promotion of skin regeneration in diabetic rats by electrospun core-sheath fibers loaded with basic fibroblast growth factor

Yang, Ye; Xia, Tian; Zhi, Wei; Li, Wei; Weng, Jie; Zhang, Cong; Li, Xiaohong

doi:10.1016/j.biomaterials.2011.02.042

Cited by 313 publications

(208 citation statements)

References 36 publications

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“…76 In emulsion electrospinning, the drug or aqueous protein solution is emulsified within a polymer solution, which is referred to as the oil phase, and after electrospinning, the biomolecule-loaded phase can be distributed within the fibers if a low-molecular-weight drug is used 77 or form a core-shell fibrous structure when macromolecules are incorporated in the aqueous phase. 75,76,78,79 The ratio of aqueous/polymer solution is one of the effective parameters that affects the distribution of the biomolecules within the fibers, a phenomenon that can subsequently affect the release profiles, structural stability, and bioactivity of the encapsulated proteins. 75 The potential advantage of emulsion electrospinning over the conventional blending technique is that the drug and polymer are dissolved in appropriate solvents, eliminating the need for a common solvent.…”

Section: Emulsion Electrospinningmentioning

confidence: 99%

“…110 Although the controlled release of GFs is achievable, the instability of GFs hinders the successful development of GF-loaded tissue-engineering scaffolds. Various techniques, such as blending, 91,111 specific or nonspecific surface modifications, 57,[60][61][62][63]105 coaxial electrospinning, 56 emulsion electrospinning, 79,88 and combination of electrospinning with other conventional techniques, 112,113 were applied for GF incorporation into nanofibrous scaffolds, yielding varied level of success. Burst release of EGF was obtained from silk nanofibers blended with EGF, due to the hydrophobic nature of EGF.…”

Section: 108mentioning

confidence: 99%

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Advances in drug delivery via electrospun and electrosprayed nanomaterials

Zamani¹,

Prabhakaran²,

Ramakrishna³

2013

IJN

201

104

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Electrohydrodynamic (EHD) techniques refer to procedures that utilize electrostatic forces to fabricate fibers or particles of different shapes with sizes in the nano-range to a few microns through electrically charged fluid jet. Employing different techniques, such as blending, surface modification, and coaxial process, there is a great possibility of incorporating bioactive such molecules as drugs, DNA, and growth factors into the nanostructures fabricated via EHD techniques. By careful selection of materials and processing conditions, desired encapsulation efficiency as well as preserved bioactivity of the therapeutic agents can be achieved. The drug-loaded nanostructures produced can be applied via different routes, such as implantation, injection, and topical or oral administration for a wide range of disease treatment. Taking advantage of the recent developments in EHD techniques like the coaxial process or multilayered structures, individually controlled delivery of multiple drugs is achievable, which is of great demand in cancer therapy and growth-factor delivery. This review summarizes the most recent techniques and postmodification methods to fabricate electrospun nanofibers and electrosprayed particles for drug-delivery applications.

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Section: Emulsion Electrospinningmentioning

confidence: 99%

Section: 108mentioning

confidence: 99%

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Zamani¹,

Prabhakaran²,

Ramakrishna³

2013

IJN

201

104

View full text Add to dashboard Cite

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“…It was used in the treatment of diabetic neuropathic ulcers. 58 Other growth factors investigated in the wound dressings include EGF, 59 VEGF, 60 bFGF, 61 and TGF-b. 62 Conventional delivery methods often provide growth factors in the soluble form, which results in a burst release causing severe side effects such as hypotension (e.g., VEGF) and nephrotoxicity (e.g., bFGF).…”

Section: Biochemical Cuesmentioning

confidence: 99%

Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment

Xiao

Ahadian

Radišić

2017

Tissue Engineering Part B: Reviews

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Progress in biomaterial science and engineering and increasing knowledge in cell biology have enabled us to develop functional biomaterials providing appropriate biochemical and biophysical cues for tissue regeneration applications. Tissue regeneration is particularly important to treat chronic wounds of people with diabetes. Understanding and controlling the cellular microenvironment of the wound tissue are important to improve the wound healing process. In this study, we review different biochemical (e.g., growth factors, peptides, DNA, and RNA) and biophysical (e.g., topographical guidance, pressure, electrical stimulation, and pulsed electromagnetic field) cues providing a functional and instructive acellular matrix to heal diabetic chronic wounds. The biochemical and biophysical signals generally regulate cell-matrix interactions and cell behavior and function inducing the tissue regeneration for chronic wounds. Some technologies and devices have already been developed and used in the clinic employing biochemical and biophysical cues for wound healing applications. These technologies can be integrated with smart biomaterials to deliver therapeutic agents to the wound tissue in a precise and controllable manner. This review provides useful guidance in understanding molecular mechanisms and signals in the healing of diabetic chronic wounds and in designing instructive biomaterials to treat them.

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“…Since then, many other antibiotics (40,42) as well as various antiseptics (43), antifungals (5), non--steroidal anti-inflammatory agents (44), anti-cancer drugs (40,45) as well as biomolecules such as proteins (5,7,21,46) and nucleic acids (47) have been built into or adsorbed on nanofibers. For example, Choi and his colleagues bound the recombinant human epidermal growth factor on the surface of polycaprolactone and poly(ethylene oxide) nanofibers and proved that the growth factor retained its biological activity (7).…”

Section: Nanofibers As Progressive Dressings For Chronic Wound Therapymentioning

confidence: 99%

“…The in vitro investigation of Yang et al indicated that nanofibers loaded with fibroblast growth factor enhanced adhesion, proliferation and secretion of ECM of mouse embryonic fibroblasts. After an initial burst effect, a gradual release over about four weeks was achieved, whereas re--epithelialization and mature capillary vessels were generated after 14 days (46). The latest approach in managing bacterial infections in chronic wounds is the embedment of silver nanoparticles as effective antimicrobial agents into nanofibers (48).…”

Section: Nanofibers As Progressive Dressings For Chronic Wound Therapymentioning

confidence: 99%

Nanofibers and their biomedical use

Rošic¹,

Kocbek²,

Pelipenko³

et al. 2013

Acta Pharmaceutica

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The idea of creating replacement for damaged or diseased tissue, which will mimic the physiological conditions and simultaneously promote regeneration by patients’ own cells, has been a major challenge in the biomedicine for more than a decade. Therefore, nanofibers are a promising solution to address these challenges. These are solid polymer fibers with nanosized diameter, which show improved properties compared to the materials of larger dimensions or forms and therefore cause different biological responses. On the nanometric level, nanofibers provide a biomimetic environment, on the micrometric scale three-dimensional architecture with the desired surface properties regarding the intended application within the body, while on the macrometric scale mechanical strength and physiological acceptability. In the review, the development of nanofibers as tissue scaffolds, modern wound dressings for chronic wound therapy and drug delivery systems is highlighted. Research substantiates the effectiveness of nanofibers for enhanced tissue regeneration, but ascertains that evidences from clinical studies are currently lacking. Nevertheless, due to the development of nano- and bio-sciences, products on the market can be expected in the near future.

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Promotion of skin regeneration in diabetic rats by electrospun core-sheath fibers loaded with basic fibroblast growth factor

Cited by 313 publications

References 36 publications

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Advances in drug delivery via electrospun and electrosprayed nanomaterials

Biochemical and Biophysical Cues in Matrix Design for Chronic and Diabetic Wound Treatment

Nanofibers and their biomedical use

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