Coating Carbon Nanosphere with Patchy Gold for Production of Highly Efficient Photothermal Agent

Abstract

Gold- or carbon-based photothermal therapy (PTT) agents have shown encouraging therapeutic effects of PTT in the near-infrared region (NIR) in many preclinical animal experiments. It is expected that gold/carbon hybrid nanomaterial will possess combinational NIR light absorption and can achieve further improvement in photothermal conversion efficiency. In this work, we design and construct a novel PTT agent by coating a carbon nanosphere with patchy gold. To synthesize this composite particle with Janus structure, a new versatile approach based on a facile adsorption-reduction method was presented. Different from the conventional fabrication procedures, the formation of patchy gold in this approach is mainly a thermodynamics-driven spontaneous process. The results show that when compared with the conventional PTT agent gold nanorod the obtained nanocomposites not only have higher photothermal conversion efficiency but also perform more thermally stable. On the basis of these outstanding photothermal effects, the in vitro and in vivo photothermal performances in a MCF-7 cells (human breast adenocarcinoma cell line) and mice were investigated separately. Additionally, to further illustrate the advantage of this asymmetric structure, their potential was explored by selective surface functionalization, taking advantage of the affinity of both patchy gold and carbon domain to different functional molecules. These results suggest that this new hybrid nanomaterial can be used as an effective PTT agent for cancer treatment in the future.

Upconversion-Magnetic Carbon Sphere for Near Infrared Light-Triggered Bioimaging and Photothermal Therapy

“…If laser irradiation was stopped, the temperature decreased (Figure S9B left). Furthermore, the photothermal conversion efficiency of the FeCUPs (400 μg/mL) was calculated as 47.4% using a previous method (Figure S9B right) 45,46, which was higher than most current photothermal carbon material agents 47,48.…”

2D Dendritic Gold Nanostructures Formed on Silica Nanosheets: Transferability, Clean Surface, and Their Biomedical Application

“…The controlled synthesis of nanostructured gold has been attracting extensive interests in the past decades due to their shape/size‐dependent optical property, which can be used in different fields ranging from catalyst, sensor to diagnosis . For instance, anisotropic features in nonspherical gold nanostructures make them ideal optical absorbing agents for transferring near‐infrared (NIR) irradiation into heat resulting from the associated surface plasmon resonance (SPR), which has been utilized in photothermal therapy (PTT) of cancer .…”

Nanoscale Metal–Organic Frameworks Decorated with Graphene Oxide for Magnetic Resonance Imaging Guided Photothermal Therapy

“…[7] On the other hand, current cancert reatments mainly employ radio-and chemotherapy, which destroyn ormal cells and healthyt issue duringt reatment, and eventually the immunity of patients. [10][11][12][13][14] PTT can utilize heat generated from photothermal agents undern ear-infrared( NIR) light irradiation to ablate cancerous cells. [10][11][12][13][14] PTT can utilize heat generated from photothermal agents undern ear-infrared( NIR) light irradiation to ablate cancerous cells.…”

“…[8,9] As ap romising alternative to traditional cancer therapies, recently,p hotothermal therapy (PTT) has been extensively explored for future cancer treatment. [10][11][12][13][14] PTT can utilize heat generated from photothermal agents undern ear-infrared( NIR) light irradiation to ablate cancerous cells. To enhancet he efficiency of simultaneous diagnosis and therapy for cancer ando ther diseases, integratingimaging tools (such as MRI, computed tomography (CT), or positron emissiont omography) with PTT is urgently required to fight cancer.…”

“…On the other hand, current cancer treatments mainly employ radio‐ and chemotherapy, which destroy normal cells and healthy tissue during treatment, and eventually the immunity of patients . As a promising alternative to traditional cancer therapies, recently, photothermal therapy (PTT) has been extensively explored for future cancer treatment . PTT can utilize heat generated from photothermal agents under near‐infrared (NIR) light irradiation to ablate cancerous cells.…”