The realization of porous materials for highly selective separation of acetylene (C2H2) from various other gases (e.g., carbon dioxide and ethylene) by adsorption is of prime importance but challenging in the petrochemical industry. Herein, a chemically stable Hofmann‐type metal−organic framework (MOF), Co(pyz)[Ni(CN)4] (termed as ZJU‐74a), that features sandwich‐like binding sites for benchmark C2H2 capture and separation is reported. Gas sorption isotherms reveal that ZJU‐74a exhibits by far the record C2H2 capture capacity (49 cm3 g−1 at 0.01 bar and 296 K) and thus ultrahigh selectivity for C2H2/CO2 (36.5), C2H2/C2H4 (24.2), and C2H2/CH4 (1312.9) separation at ambient conditions, respectively, of which the C2H2/CO2 selectivity is the highest among all the robust MOFs reported so far. Theoretical calculations indicate that the oppositely adjacent nickel(II) centers together with cyanide groups from different layers in ZJU‐74a can construct a sandwich‐type adsorption site to offer dually strong and cooperative interactions for the C2H2 molecule, thus leading to its ultrahigh C2H2 capture capacity and selectivities. The exceptional separation performance of ZJU‐74a is confirmed by both simulated and experimental breakthrough curves for 50/50 (v/v) C2H2/CO2, 1/99 C2H2/C2H4, and 50/50 C2H2/CH4 mixtures under ambient conditions.

The separation of ethane (C 2 H 6 ) from ethylene (C 2 H 4 ) is of prime importance in the production of polymergrade C 2 H 4 for industrial manufacturing. It is very challenging and still remains unexploited to fully realize efficient C 2 H 6 / C 2 H 4 separation in the emerging hydrogen-bonded organic frameworks (HOFs) due to the weak nature of hydrogen bonds. We herein report the benchmark example of a novel ultrarobust HOF adsorbent (termed as HOF-76a) with a Brunauer− Emmett−Teller surface area exceeding 1100 m 2 g −1 , exhibiting the preferential binding of C 2 H 6 over C 2 H 4 and thus highly selective separation of C 2 H 6 /C 2 H 4 . Theoretical calculations indicate the key role of the nonpolar surface and the suitable triangular channel-like pores in HOF-76a to sterically "match" better with the nonplanar C 2 H 6 molecule than the planar C 2 H 4 , thus affording overall stronger multipoint van der Waals interactions with C 2 H 6 . The exceptional separation performance of HOF-76a for C 2 H 6 /C 2 H 4 separation was clearly demonstrated by gas adsorption isotherms, ideal adsorbed solution theory calculations, and simulated and experimental breakthrough curves. Breakthrough experiments on HOF-76a reveal that polymer-grade ethylene gas can be straightforwardly produced from 50/50 (v/v) C 2 H 6 /C 2 H 4 mixtures during the first adsorption cycle with a high productivity of 7.2 L/kg at 298 K and 1.01 bar and 18.8 L/kg at 298 K and 5.0 bar, respectively.

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Tumor-associated macrophages have important roles in hepatocellular carcinoma (HCC) initiation and progression. Long noncoding RNAs(lncRNAs) have also been reported to be involved in HCC. In this study, we explored how lncRNA LINC00662 may influence HCC progression through both tumor cell-dependent and macrophage-dependent mechanisms. LINC00662 was found to be upregulated in HCC, and high LINC00662 levels correlated with poor survival of HCC patients. LINC00662 upregulated WNT3A expression and secretion via competitively binding miR-15a, miR-16, and miR-107. Through inducing WNT3A secretion, LINC00662 activated Wnt/b-catenin signaling in HCC cells in an autocrine manner and further promoted HCC cell proliferation, cell cycle, and tumor cell invasion, while repressing HCC cell apoptosis. In addition, acting through WNT3A secretion, LINC00662 activated Wnt/b-catenin signaling in macrophages in a paracrine manner and further promoted M2 macrophage polarization. Via activating Wnt/b-catenin signaling and M2 macrophages polarization, LINC00662 significantly promoted HCC tumor growth and metastasis in vivo. Hence, targeting LINC00662 may provide novel therapeutic strategy against HCC. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68, 394-424. Budhu A, Forgues M, Ye QH, Jia HL, He P, Zanetti KA, Kammula US, Chen Y, Qin LX, Tang ZY et al. (2006) Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 10, 99-111. Carlson P, Dasgupta A, Grzelak CA, Kim J, Barrett A, Coleman IM, Shor RE, Goddard ET, Dai J, Schweitzer EM et al. (2019) Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy. Nat Cell Biol 21, 238-250. Cassetta L, Fragkogianni S, Sims AH, Swierczak A, Forrester LM, Zhang H, Soong DYH, Cotechini T, Anur P, Lin EY et al. (2019) Human tumor-associated macrophage and monocyte transcriptional landscapes reveal cancer-specific reprogramming, biomarkers, and therapeutic targets. Cancer Cell 35, 588-602 e510. Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M, Tramontano A and Bozzoni I (2011) A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell 147, 358-369. Chandradoss SD, Schirle NT, Szczepaniak M, MacRae IJ and Joo C (2015) A dynamic search process underlies microRNA targeting. Cell 162, 96-107. PP et al. (2019a) Extracellular vesicle-packaged HIF-1alpha-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells. Nat Cell Biol 21, 498-510. X et al. (2019b) TNF-alpha derived from M2 tumor-asso...

Purification of C 2 H 4 from a ternary C 2 H 2 /C 2 H 6 /C 2 H 4 mixture by one-step adsorption separation is of prime importance but challenging in the petrochemical industry; however, effective strategies to design high-performance adsorbents are lacking. We herein report for the first time the incorporation of Lewis basic sites into a C 2 H 6 -selective MOF, enabling efficient one-step production of polymer-grade C 2 H 4 from ternary mixtures. Introduction of amino groups into highly stable C 2 H 6 -selective UiO-67 can not only partition large pores into smaller cagelike pockets to provide suitable pore confinement but also offer additional binding sites to simultaneously enhance C 2 H 2 and C 2 H 6 adsorption capacities over C 2 H 4 . The amino-functionalized UiO-67-(NH 2 ) 2 thus exhibits exceptionally high C 2 H 2 and C 2 H 6 uptakes as well as benchmark C 2 H 2 /C 2 H 4 and C 2 H 6 /C 2 H 4 selectivities, surpassing all of the C 2 H 2 /C 2 H 6 -selective materials reported so far. Theoretical calculations combined with in situ infrared spectroscopy indicate that the synergetic effect of suitable pore confinement and functional surfaces decorated with amino groups provides overall stronger multipoint van der Waals interactions with C 2 H 2 and C 2 H 6 over C 2 H 4 . The exceptional performance of UiO-67-(NH 2 ) 2 was evidenced by breakthrough experiments for C 2 H 2 /C 2 H 6 /C 2 H 4 mixtures under dry and wet conditions, providing a remarkable C 2 H 4 productivity of 0.55 mmol g −1 at ambient conditions.

Cell metabolism is strongly influenced by mechano-environment. We show here that a fraction of kindlin-2 localizes to mitochondria and interacts with pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme for proline synthesis. Extracellular matrix (ECM) stiffening promotes kindlin-2 translocation into mitochondria and its interaction with PYCR1, resulting in elevation of PYCR1 level and consequent increase of proline synthesis and cell proliferation. Depletion of kindlin-2 reduces PYCR1 level, increases reactive oxygen species (ROS) production and apoptosis, and abolishes ECM stiffening-induced increase of proline synthesis and cell proliferation. In vivo, both kindlin-2 and PYCR1 levels are markedly increased in lung adenocarcinoma. Ablation of kindlin-2 in lung adenocarcinoma substantially reduces PYCR1 and proline levels, and diminishes fibrosis in vivo, resulting in marked inhibition of tumor growth and reduction of mortality rate. Our findings reveal a mechanoresponsive kindlin-2-PYCR1 complex that links mechano-environment to proline metabolism and signaling, and suggest a strategy to inhibit tumor growth.

Since September 2018, LAMOST starts a new 5-year medium-resolution spectroscopic survey (MRS) using bright/gray nights. We present the scientific goals of LAMOST-MRS and propose a near optimistic strategy of the survey. A complete footprint is also pro-

The pore size and low-polarity pore surface are systematically engineered within a series of C2H6-selective MOF materials for targeting high C2H6 uptake capacity, high C2H6/C2H4 selectivity and moderate C2H6 adsorption heat simultaneously.