Co-exposure to non-toxic levels of cadmium and fluoride induces hepatotoxicity in rats via triggering mitochondrial oxidative damage, apoptosis, and NF-kB pathways

Arab-Nozari, Milad; Mohammadi, Ebrahim; Shokrzadeh, Mohammad; Ahangar, Nematollah; Amiri, Fereshteh Talebpour; Shaki, Fatemeh

doi:10.1007/s11356-020-08791-4

Cited by 29 publications

(10 citation statements)

References 41 publications

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“…Cell viability at 12 hours was determined DOI:10.31557/APJCP.2021.22.S1.49 Anticancer Potential of Crude Venom of Conus Textile spectrophotometer at an excitation wavelength of 488 nm and emission wavelength of 527. Three independent experiments were run for mitochondrial ROS formation determination (Salimi et al, 2016;Arab-Nozari et al, 2020).…”

Section: Cell Viability Assessmentmentioning

confidence: 99%

Persian Gulf Snail Crude Venom (Conus textile): A Potential Source of Anti-Cancer Therapeutic Agents for Glioblastoma through Mitochondrial-Mediated Apoptosis

Salimi

Rahimitabar

Vazirizadeh

et al. 2021

Asian Pac J Cancer Prev

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Animal toxins are made of types of peptides and proteins well-tuned during millions of years of evolution (Escoubas and King, 2009). These venoms target various enzymes, receptors, and ion channels with great potency and sometimes good selectivity, hence, it is led to more attention to more research their physiological and pharmacological attributes (Escoubas and King, 2009). These venoms are made by poisonous animals from both marine animals and terrestrial animals, are injected into the body of victim for defense or hunt by animal wounding apparatus (Harvey, 2014). For thousand years in many parts of the world, some poisonous animals have been applied to remedy illnesses (Harvey, 2014). It has been

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Section: Cell Viability Assessmentmentioning

confidence: 99%

Persian Gulf Snail Crude Venom (Conus textile): A Potential Source of Anti-Cancer Therapeutic Agents for Glioblastoma through Mitochondrial-Mediated Apoptosis

Salimi

Rahimitabar

Vazirizadeh

et al. 2021

Asian Pac J Cancer Prev

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“…Next, we tried to understand the mechanism by which ROS and the ERK/p38MAPK pathway are associated with other molecular events closely linked to keratinocyte apoptosis induced by PM 10 . NF-κB, a redox-sensitive transcription factor, plays an important role in the gene transcription of the apoptotic signaling pathway in many epithelial cells when during exposure to various environmental contaminants, including fluoride, insecticides, and PM [24][25][26]. Indeed, it has been reported that NF-κB transcriptionally mediates the expression levels of many pro-inflammatory regulators and apoptotic genes in skin inflammation and damage [27].…”

Section: Discussionmentioning

confidence: 99%

Tart Cherry Extract Containing Chlorogenic Acid, Quercetin, and Kaempferol Inhibits the Mitochondrial Apoptotic Cell Death Elicited by Airborne PM10 in Human Epidermal Keratinocytes

Kim

Jung

Sung³

et al. 2021

Antioxidants

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Tart cherry (Prunus cerasus L.), a medicinal food containing high concentrations of phytochemicals, has a variety of antioxidant activities and health benefits. Here, we investigate the functional effect of tart cherry during apoptotic cell death elicited by airborne particulate matter with a diameter of <10 μm (PM10) in human epidermal keratinocyte HaCaT cells. The PM10 particles significantly induced cytotoxicity in the HaCaT cells. The decrease in cell viability was restored upon treatment with tart cherry extract (200 μg/mL) containing chlorogenic acid, quercetin, and kaempferol. Tart cherry inhibited the intracellular reactive oxygen species (ROS) responsible for the distinctive activations of the extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) in PM10-treated HaCaT cells. Interestingly, tart cherry significantly inhibited the expression of apoptosis-related genes (B-Cell Lymphoma 2 (Bcl-2), Bcl-2 associated X protein (Bax), and caspase-3) as regulated by the activation of transcription factor nuclear factor-kappa B (NF-κB). These results demonstrate that tart cherry is a medicinal food that blocks the mitochondrial pathway of apoptosis induced by PM10 in human epidermal keratinocytes.

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“…Cadmium chloride is a heavy metal that causes environmental pollution it is widely present in the soil, food, air, and water in various concentration [1].…”

Section: Introductionmentioning

confidence: 99%

Effect of Cadmium Chloride on the Histological Structure of Lung in Adult Male Mice with and without Parsley Oil

Al-Sammak

2021

Open Access Maced J Med Sci

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This study is to detect the toxic effect of cadmium chloride on the histological structure of the lung and the effect of parsley oil to amilorate these changes In this experiement 40 adult male mice were divided into four groups. Goup A (control group) in this group animals were injected with the normal saline intraperitoneally single daily dose for 30 days. Group B injected intrapertioneally with cadmium chloride single daily dose 3.5 mg/kg body weight for 30 days. Group C injected intraperetonially with cadmium chloride in a dose of 3.5 mg/kg body weight. Intragastric tube was put to recieve parsley oil in a dose of 0.5 ml/kg body weight prior to cadmium injection. The two drugs were given for 30 days. Group D recieved 0.5 ml/kg body weight by intragastric tube of parsley oil for 30 days. At the end of this experiement, the animals were sacrified the lungs were collected from all groups and prepared for light microscopical examination. Histological changes were detected in cadmium chloride treated group in comparison with the control group including congestion, inflammatory cell infiltration, interstial pneumonia (decreased alveolar space), thickening of interalveolar septum and damge to the alveolar cells. All these changes were eliminated by giving parsley oil.

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Co-exposure to non-toxic levels of cadmium and fluoride induces hepatotoxicity in rats via triggering mitochondrial oxidative damage, apoptosis, and NF-kB pathways

Cited by 29 publications

References 41 publications

Persian Gulf Snail Crude Venom (Conus textile): A Potential Source of Anti-Cancer Therapeutic Agents for Glioblastoma through Mitochondrial-Mediated Apoptosis

Persian Gulf Snail Crude Venom (Conus textile): A Potential Source of Anti-Cancer Therapeutic Agents for Glioblastoma through Mitochondrial-Mediated Apoptosis

Tart Cherry Extract Containing Chlorogenic Acid, Quercetin, and Kaempferol Inhibits the Mitochondrial Apoptotic Cell Death Elicited by Airborne PM10 in Human Epidermal Keratinocytes

Effect of Cadmium Chloride on the Histological Structure of Lung in Adult Male Mice with and without Parsley Oil

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