Effect of Cadmium Chloride on the Histological Structure of Lung in Adult Male Mice with and without Parsley Oil

Abstract

This study is to detect the toxic effect of cadmium chloride on the histological structure of the lung and the effect of parsley oil to amilorate these changes 
 In this experiement 40 adult male mice were divided into four groups. Goup A (control group) in this group animals were injected with the normal saline intraperitoneally single daily dose for 30 days.
 Group B injected intrapertioneally with cadmium chloride single daily dose 3.5 mg/kg body weight for 30 days.
 Group C injected intraperetonially with cadmium chloride in a dose of 3.5 mg/kg body weight. Intragastric tube was put to recieve parsley oil in a dose of 0.5 ml/kg body weight prior to cadmium injection. The two drugs were given for 30 days.
 Group D recieved 0.5 ml/kg body weight by intragastric tube of parsley oil for 30 days.
 At the end of this experiement, the animals were sacrified the lungs were collected from all groups and prepared for light microscopical examination.
 Histological changes were detected in cadmium chloride treated group in comparison with the control group including congestion, inflammatory cell infiltration, interstial pneumonia (decreased alveolar space), thickening of interalveolar septum and damge to the alveolar cells. All these changes were eliminated by giving parsley oil.

Experimental and Clinical Studies on the Effects of Natural Products on Noxious Agents-Induced Lung Disorders, a Review

“…ameliorated the Cd-induced lung damage with the reduction of histopathological changes in the lung architecture ( 41 ). The treatment effects of Tribulus Terrestris against the Cd-induced toxicity in the mice showed that the alcoholic extract of Tribulus Terrestris fruit (200 mg/kg, for 10 days) eliminated the free radicals and increased the antioxidant enzymes expression as well as the down-regulation of pro-inflammatory markers in cellular injuries ( 42 ). The anti-inflammatory effects of the phenolic compounds from grape seeds were associated with their regulatory effect on the expression of the pro-inflammatory genes, such as cyclooxygenase and lipoxygenase and also by acting on the NF-κB signaling and MAPK.…”

Effects of cadmium acetate contaminated drinking water on vital organs: A histopathological and biochemical study

“…[ 23 ] CdCl 2 may cause tissue necrosis or apoptosis in rats and mice after prolonged exposure. [ 24 ] CdCl 2 in rats (5 mg/kg orally for 4 weeks) may create an imbalance in liver enzyme levels, [ 25 ] nephropathy, [ 26 ] and proteinuria. [ 27 ]…”