Co-existing active pulmonary tuberculosis with aspergilloma in a diabetic patient: A rare case report

Soewondo, Widiastuti; Kusumaningrum, Candra Sari; Hanafi, Mamduh M.; Adhiputri, Artrien; Hayuningrat, Prima Kharisma

doi:10.1016/j.radcr.2021.12.064

Cited by 4 publications

(8 citation statements)

References 12 publications

(13 reference statements)

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“…In this country, due to the high incidence of tuberculosis, which is 301 per 100,000 population [6] , infection of tuberculosis mediastinal abscess was the first to be included in the differential diagnosis. Additionally, tuberculosis is known as a disease with many characteristics and may co-exist with another disease, such as aspergilloma [7] . Tuberculosis mediastinal abscess is a rare manifestation in immunocompetent adults.…”

Section: Discussionmentioning

confidence: 99%

A 19-year-old woman with mature pericardial teratoma

Natalie

Widiastuti

Widyasari

et al. 2023

Radiology Case Reports

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Section: Discussionmentioning

confidence: 99%

A 19-year-old woman with mature pericardial teratoma

Natalie

Widiastuti

Widyasari

et al. 2023

Radiology Case Reports

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“…According to the literature, pulmonary aspergillosis is often accompanies of tuberculosis, especially in residual tuberculous cavities [4,9], and type 2 [11] diabetes mellitus [1] is one of the most common premorbid backgrounds for Aspergillus invasion into the bronchi. It established, that hyperglycemia in diabetes mellitus contributes to the development of immunodeficiency [11], so the control of blood glucose levels is requirement for success in both the treatment of aspergillosis and its combination with other diseases [4,10,11].…”

Section: Discussionmentioning

confidence: 99%

“…The clinical picture of pulmonary aspergillosis is determined by the interaction between the fungus Aspergillus and the host [9]. Pulmonary aspergilloma is often associated with tuberculosis (TB) and is found in residual tuberculous cavities, as sufficient oxygen and caseous necrosis contribute its growth in this location [4].…”

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Features of the simultaneous course of pulmonary aspergillosis and tuberculosis on the background of type 1 diabetes mellitus (clinical case)

Raznatovska

Mironchuk²,

Shalmin

et al. 2022

Patologìâ

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Aim. To analyze the features of the simultaneous course of pulmonary aspergillosis and multidrug-resistant pulmonary tuberculosis (MDR-TB) on the background of type 1 diabetes mellitus, on the example of a clinical case of our practice. Materials and methods. Clinical case of our practice of simultaneous pulmonary aspergillosis and MDR-TB on the background of type 1 diabetes mellitus in a patient, who was treated in Pulmonary tuberculosis department No. 2 of clinical base of Phthisiatry and Pulmonology Department of Zaporizhzhia State Medical University at Communal Non-Commercial Enterprise of the “Zaporizhzhia Regional Clinical and Diagnostic Center of Phthisiatry and Pulmonology” of Zaporizhzhia Regional Council. Results. In the presented clinical case, the patient had been suffering from diabetes mellitus for 8 years and had been receiving insulin therapy for all these years. One year before the TB disease, he had contact with an index patient, but he categorically refused a course of preventive chemotherapy. Also, the patient did not make a comparison X-ray TCO after 6 months, as a contact person. MDR-TB and aspergilloma of the left lung of the patient were diagnosed simultaneously on the background of severe condition with decompensated form of type 1 diabetes mellitus, severe intoxication syndrome and inflammatory process, massive hemoptysis. Aspergilloma of the left lung was diagnosed using X-ray TCO and cultural examination of bronchial aspirate for Aspergillus, which was not difficult to diagnose. Diagnosis of MDR-TB was also not difficult, because the patient had MBT, which contributed to the timely and correct appointment of antimycobacterial therapy. Surgery for aspergilloma of the left lung was contraindicated, as the type 1 diabetes was in decompensation. Persistent hyperglycemia remained, despite the fact of antifungal therapy and constant correction of insulin therapy prescribed for the patient. Endocarditis quickly developed in the patient, which was the reason of patient’s death. Conclusions. The decompensated form of type 1 diabetes mellitus caused persistent hyperglycemia, which was the reason of immune disorders and this made the patient’s body susceptible to bacterial (MDR-TB) and fungal (aspergillosis) infections, which led to the development of the complication of endocarditis and death. A big mistake in his case, was a categorical refusal by the patient to receive a course of preventive chemotherapy, as a contact person with an index patient. In view of this, in the presence of type 1 diabetes, the patient should have not neglected it. And as a result, the patient had a MDR-TB, one year after. At the same time, the patient did not make a comparison X-ray TCO, after 6 months, as a contact person, which was a possible reason for the missing of early diagnosis of pulmonary aspergilloma. That’s why, a correct treatment of type 1 diabetes mellitus and timely preventive radiological examination of the thoracic cavity organs are especially important, as the diabetes mellitus is the most common premorbid background for TB and aspergillosis.

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“…Thorax CT scoring is deemed a reliable way for diagnosing COVID-19. Repeated CT scoring is necessary for the follow-up [9,[14][15][16][17][18][19][20].…”

Section: Correlation Between Diagnostic Value and Severity Of Covid-1...mentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio in combination with d-dimer, an indicator for the severity of COVID-19 with comorbidity: A literature review

Soewondo¹

2022

GSC Adv. Res. Rev.

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Introduction: A new coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was initially detected in Wuhan, China. Material and Methods: Literature search of the latest articles published in PubMed, Google Scholar, and Cochrane Library databases from 2019 to 2021 was carried out. All articles were searched independently by two reviewers (W and X.X., with 10 and 5 years of experience in Radiology, respectively). Results: Thirty seven articles were identified and screened for eligibility. Of these, 25 articles were included in this review. Cardiovascular disease, CHD, DM, hypertension and COPD are comorbidities hypertension and COPD are comorbidities increasing the risk of severity in COVID-19 subjects. Conclusion: Neutrophil-to-lymphocyte Radio in combination with D-Dimer index is a competent marker for predicting COVID-19 severity. The primary preferred technique for diagnosing COVID-19 is RT-PCR of SARS-CoV-2 RNA. Chest-CT scan is a common easy practice producing rapid COVID-19 diagnosis.

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Co-existing active pulmonary tuberculosis with aspergilloma in a diabetic patient: A rare case report

Cited by 4 publications

References 12 publications

A 19-year-old woman with mature pericardial teratoma

A 19-year-old woman with mature pericardial teratoma

Features of the simultaneous course of pulmonary aspergillosis and tuberculosis on the background of type 1 diabetes mellitus (clinical case)

Neutrophil-to-lymphocyte ratio in combination with d-dimer, an indicator for the severity of COVID-19 with comorbidity: A literature review

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