Clinical evaluation of the role of tulsi and turmeric in the management of oral submucous fibrosis: A pilot, prospective observational study

Srivastava, Arvind; Agarwal, Rahul; Chaturvedi, TP; Chandra, Akhilesh; Singh, O. P.

doi:10.4103/0975-9476.146563

Cited by 65 publications

(7 citation statements)

References 14 publications

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“…Various studies are stated in the literature with significant mean improvement in mouth opening using levamisole (2.9 mm), antoxid (3.1 mm), lycopene (3.4 mm, 5.38 mm), lycopene with Vitamin E (6.2 mm), pentoxifylline (7 mm), pentoxifylline with garlic pearls (5 mm), turmeric with tulsi (3–4 mm), and turmeric with black pepper (3.8 mm). [81416171819] Group A patients in the present study have shown equivalent results to antoxid, levamisole, turmeric with tulsi, and turmeric with black pepper. Group B patients have shown comparable results to lycopene, lycopene with Vitamin E, and pentoxifylline with garlic pearls.…”

Section: Discussionsupporting

confidence: 54%

Efficacy of spirulina along with different physiotherapeutic modalities in the management of oral submucous fibrosis

Kanjani

Annigeri

Revanappa

et al. 2019

Ann Maxillofac Surg

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Context: Oral submucous fibrosis (OSMF) is an insidious, chronic, disabling disease that mainly affects the oral mucosa. Spirulina is a freshwater microalga which is considered as superfood by the WHO. Due to its antioxidant, anti-inflammatory, and immunomodulating properties, spirulina has shown promising results in the management of OSMF. A wide range of treatment modalities have been tried ranging from medical, physical, or surgical interventions, but combinations of these have shown better results. Aims: The study aimed to evaluate the efficacy of spirulina along with different physiotherapeutic modalities in the management of OSMF. Setting and Design: The present comparative study was conducted in the Department of Oral medicine and radiology, College of Dental Sciences, Davangere, Karnataka, India. The block randomization technique was used in the present study to enroll patients into three different groups. Methods: The study consisted of 45 OSMF patients who were divided randomly into three groups. All patients were given spirulina 500 mg twice a day for 3 months. Group A patients were instructed to perform isometric mouth exercises for 20 min, twice daily. Group B patients and Group C patients perform exercises using threaded tapered screw and mouth stretching device (MSD), respectively, ten times bilaterally twice a day. Clinical parameters such as burning sensation, mouth opening, tongue protrusion, and cheek flexibility were assessed every 15 days. Statistical Analysis Used: Descriptive data that included mean, numbers, and percentages were calculated for each group and were used for analysis. For intra- and inter-group comparison, paired t- and unpaired t -test was used, respectively. For all the tests, P = 0.05 or less was considered for statistical significance. Results and Conclusion: All the groups have shown statistically significant improvement in burning sensation, mouth opening, tongue protrusion, and cheek flexibility ( P < 0.05). Group C patients have shown better results followed by Group B and Group A patients. In the present study, spirulina along with different physiotherapeutic modalities was well tolerated by the patients, and significant improvement was seen in the MSD group.

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Section: Discussionsupporting

confidence: 54%

Efficacy of spirulina along with different physiotherapeutic modalities in the management of oral submucous fibrosis

Kanjani

Annigeri

Revanappa

et al. 2019

Ann Maxillofac Surg

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“…Various modern forms (capsules, tablets, lozenges) of dietary supplements containing turmeric, and its bioactive compounds are commercially available. Turmeric powder with glycerin has been used in the treatment of a burning sensation in oral submucous fibrosis [182]. An ointment containing 10% alcohol extract from turmeric roots is effective in the treatment of ulcers caused by aspirin [183].…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

A Review of the Role of Curcumin in Metal Induced Toxicity

et al. 2023

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Metal toxicity poses a potential global threat to the environment and living beings. Their numerous agricultural, medical, industrial, domestic, and technological applications result in widespread distribution in the environment which raises concern on the potential effects of metals in terms of health hazards and environmental pollution. Chelation therapy has been the preferred medical treatment for metal poisoning. The chelating agent bounds metal ions to form complex cyclic structures known as ‘chelates’ to intensify their excretion from the body. The main disadvantage of synthetic chelators is that the chelation process removes vital nutrients along with toxic metals. Natural compounds are widely available, economical, and have minimal adverse effects compared to classical chelators. Herbal preparations can bind to the metal, reduce its absorption in the intestines, and facilitate excretion from the body. Curcumin, a bioactive substance in turmeric, is widely used as a dietary supplement. Most studies have shown that curcumin protects against metal-induced lipid peroxidation and mitigates adverse effects on the antioxidant system. This review article provides an analysis to show that curcumin imparts promising metal toxicity-ameliorative effects that are related to its intrinsic antioxidant activity.

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“…Clinical features include blanching of the oral mucosa, limited mouth opening, restriction of tongue movements, burning sensation, etc. [18,19]. Through its antioxidant property and immunomodulatory effect, it produced a significant release in the burning sensation when studied clinically [18].…”

Section: Oral Submucous Fibrosis :-mentioning

confidence: 99%

Therapeutic Uses of Tulsi ( Ocimum Sanctum ) in Oral Lesions

Janakiraman,

Mohaideen,

et al. 2023

PIJR

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Since ancient times, plants have been used for various medicinal purposes in treating various diseases. Oral diseases are among the major public health problems and the most common of the chronic diseases that affect mankind. The application of natural products for the control of oral diseases is considered an interesting alternative to synthetic antimicrobials due to their lower negative impact. Ocimum sanctum (Tulsi) is a plant with enormous properties for curing and preventing diseases through its greater medicinal value. This article reviews the therapeutic role of Tulsi (Ocimum sanctum) in various oral lesions

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Clinical evaluation of the role of tulsi and turmeric in the management of oral submucous fibrosis: A pilot, prospective observational study

Cited by 65 publications

References 14 publications

Efficacy of spirulina along with different physiotherapeutic modalities in the management of oral submucous fibrosis

Efficacy of spirulina along with different physiotherapeutic modalities in the management of oral submucous fibrosis

A Review of the Role of Curcumin in Metal Induced Toxicity

Therapeutic Uses of Tulsi ( Ocimum Sanctum ) in Oral Lesions

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