A Review of the Role of Curcumin in Metal Induced Toxicity

Abstract

Metal toxicity poses a potential global threat to the environment and living beings. Their numerous agricultural, medical, industrial, domestic, and technological applications result in widespread distribution in the environment which raises concern on the potential effects of metals in terms of health hazards and environmental pollution. Chelation therapy has been the preferred medical treatment for metal poisoning. The chelating agent bounds metal ions to form complex cyclic structures known as ‘chelates’ to intensify their excretion from the body. The main disadvantage of synthetic chelators is that the chelation process removes vital nutrients along with toxic metals. Natural compounds are widely available, economical, and have minimal adverse effects compared to classical chelators. Herbal preparations can bind to the metal, reduce its absorption in the intestines, and facilitate excretion from the body. Curcumin, a bioactive substance in turmeric, is widely used as a dietary supplement. Most studies have shown that curcumin protects against metal-induced lipid peroxidation and mitigates adverse effects on the antioxidant system. This review article provides an analysis to show that curcumin imparts promising metal toxicity-ameliorative effects that are related to its intrinsic antioxidant activity.

Boron Compounds Mitigate 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Toxicity in Human Peripheral Blood Mononuclear Cells

“…Interestingly, the modulating effect of BA, BX, and UX on SOD activity, in the presence of TCDD, provides avenues for deeper exploration. Some studies have reported that certain compounds can exhibit restorative effects on cellular antioxidant systems when challenged with toxic agents [ 71 ]. The near normalization of SOD levels, especially in the BX co-treatment scenario, warrants further investigations into the underlying molecular pathways.…”

Alcohol-induced liver injury in signalling pathways and curcumin's therapeutic potential

“…In traditional Asian medicinal practices, curcumin has been an extensively employed therapeutic agent attributed to its multifaceted health-promoting characteristics, such as antioxidative, anti-inflammatory, antimutagenic, antimicrobial, and anticancer activities [45] . Being a polyphenol, curcumin exhibits broad biological activity, as it can interact with several cellular signalling pathways, thereby substantiating its extensive health benefits [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] .…”

Heavy Metals in Poultry Chicken and Human Health Threat: A Mini Review

“…The harmful effects of lead (Pb) might vary depending on the extent of exposure, ranging from mild physiological or biochemical abnormalities to serious pathologic disorders where different organs and systems may be damaged or their normal functions changed [31,32]. Pb inhibits the functions of numerous antioxidant defenses; low antioxidant levels can harm the neurological system, liver, kidneys, and reproductive system, among other organ systems [33]. Deposited lead (Pb) in the organ of poultry eventually enter into human's body system causing various health problem.…”