Clinical characteristics and prognosis of pediatric cryptococcosis in Beijing Children’s Hospital, 2002–2014

Liu, Linlin; Guo, Lingyun; Liu, Yue; Chen, YangQuan; Li, Shaoying; Yang, Yonghong; Liu, Gang

doi:10.1007/s00431-017-2974-0

Cited by 13 publications

(16 citation statements)

References 36 publications

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“…In terms of infection profiles of paediatric cryptococcosis, the most frequent (84%) symptom was Cryptococcus meningitis, followed by disseminated cryptococcosis (12%) and skin lesions (4%). The majority of our C. neoformans isolates (80.0%) were recovered from apparently immunocompetent children, and this agrees with previous studies in China (83.6%, 92/110), but differs from studies in USA (20.6%, 13/63) and South Africa (4.4%, 2/45) . Earlier investigations suggested that cryptococcosis primarily occurs in apparently immunocompetent adults in China .…”

Section: Discussionsupporting

confidence: 90%

“…In contrast, cryptococcosis is rare in children, even those who are HIV‐infected . However, the number of reported cases of cryptococcosis in children has increased in Africa, Europe, South America and Asia, including China . Except for the recent study in South Africa, data on the genotypic diversity and antifungal susceptibility of paediatric Cryptococcus isolates are limited.…”

Section: Discussionmentioning

confidence: 99%

“…It has been documented that paediatric cryptococcosis accounted for 0.9% of all cryptococcosis cases in South Africa . The number of reported cryptococcosis in children, however, has increased worldwide in the last decade, including China . A previous study indicated that the majority (approximately 70%) of children (>2 years old) in the Bronx, New York, USA had serologic evidence for C. neoformans infection, particularly those older than 5 years old …”

Section: Introductionmentioning

confidence: 99%

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Genotypic diversity and antifungal susceptibility of Cryptococcus neoformans isolates from paediatric patients in China

Hong

Chen

et al. 2018

Mycoses

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Cryptococcosis is a life-threatening mycosis primarily occurring in adult patients particularly those with immunosuppression such as HIV infection/AIDS. The number of reported cases of paediatric cryptococcosis has increased in the last decade around the world, including China. However, current information on the characteristics of cryptococcosis in children, particularly the genotypic diversity and antifungal susceptibility of the isolates, is limited. In the present study, a total of 25 paediatric isolates of Cryptococcus neoformans were genotyped using the ISHAM-MLST scheme. In vitro susceptibility to antifungal agents of the 22 isolates was tested using the CLSI M27-A3 method. Our analyses revealed that the genotypic diversity of C. neoformans isolates from Chinese paediatric patients was low, with ST 5 (80%) and ST 31 (12%) S U PP O RTI N G I N FO R M ATI O NAdditional supporting information may be found online in the Supporting Information section at the end of the article. Table S1. Details of the MIC for Chinese pediatric C. neoformans isolates for seven antifungals How to cite this article: Hong N, Chen M, Xu N, et al. Genotypic diversity and antifungal susceptibility of Cryptococcus neoformans isolates from paediatric patients in China. Mycoses. 2019;62:171-180. https://doi.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genotypic diversity and antifungal susceptibility of Cryptococcus neoformans isolates from paediatric patients in China

Hong

Chen

et al. 2018

Mycoses

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“…Although children account for only 0.9%–2.0% of all cryptococcal cases, the death rate is high, up to 43% ( 47 ). In a 12-year retrospective study in Beijing, 53 pediatric case-patients were encountered, of whom 41 had no underlying conditions ( 48 ). However, the denominator was unavailable.…”

Section: Discussionmentioning

confidence: 99%

Risk-Based Estimate of Human Fungal Disease Burden, China

Zhou¹,

Jiang²,

Li³

et al. 2020

Emerg. Infect. Dis.

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F ungal diseases constitute a growing problem worldwide, causing a large, but poorly quantified, impact on public health (1). The incidence of fungal infections varies according to geographic region, socioeconomic conditions, and the number of persons with underlying conditions. China is one of the largest countries in the world (largest population and third largest land area). It has almost every type of weather niche, from the Pacific coast in the south to the snowy mountains in the Qinghai-Tibet Plateau, and even tropical rain forest. Many endemic fungal infections are present in China, along with globally distributed fungal pathogens. Although China has become the world's second largest economy, it is still a developing country, with millions of impoverished citizens who are susceptible to fungal infections. Fungal keratitis, one of the major causes of avoidable blindness, has been relatively neglected (2). Moreover, old pathogens such as Histoplasma and Talaromyces marneffei (talaromycosis) have expanded (3,4); new hosts contributing to new therapies for malignant and autoimmune disease have increased (5,6); and new patterns, including aspergillosis in pulmonary tuberculosis (PTB) and chronic obstructive pulmonary disease (COPD), are emerging (7,8). In addition, the lack of effective drugs, shortages of well-trained medical care personnel, and unaffordable antifungal drugs result in severe outcomes. Therefore, an estimation of fungal disease burden is needed for China to increase public health awareness and facilitate effective interventions. As in most other countries, fungal infections are not reportable in China, and the incidence and prevalence are difficult to calculate because of the lack of population-based surveillance data and few high quality epidemiology studies. The Chinese National Fungal Diseases Surveillance System (http://www. chifungi.cn) was established on May 18, 2019, but no data have been released yet. Even with this dearth of data, we have attempted to estimate the burden of fungal disease in China. Materials and Methods Study Procedures We conducted a literature review for published epidemiology papers that discussed fungal infections in China. If no epidemiological data existed for a particular fungal disease, we estimated the burden based on fungal infection incidence or prevalence and the specific populations at risk (Figure 1; Appendix Table 1, https://wwwnc.cdc.gov/EID/article/26/9/20-0016-App1.pdf).

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“…The associated mortality was described as (20.7%) (LOMES et al, 2016). In China, this disease has affected children without underlying conditions and has shown similar consequences (LIU et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Occurrence of Cryptococcus neoformans in the excreta of urban pigeons in the municipality of Redenção in Amazônia, Brazil

et al. 2020

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Resumo Atualmente, os ecossistemas urbanos tornaram-se cada vez mais propícios aos pombos, e a população dessas aves aumentou significativamente em várias partes do mundo, incluindo o Brasil. Esse aumento se tornou um problema ambiental e de saúde pública. O objetivo desta pesquisa foi descrever a ocorrência de Cryptococcus neoformans nos excrementos de pombos em locais públicos do município de Redenção, Pará, Brasil. Trata-se de um estudo transversal, quantitativo e descritivo. Foram selecionados dez bairros, onde foram coletadas 5 amostras de cada um, totalizando 50 unidades de material. O fungo foi identificado através de excrementos suspensos com solução estéril de cloreto de sódio a 0,9%, seguida de semeadura em ágar Sabouraud Dextrose mais cloranfenicol. Um exame direto das colônias com tinta chinesa foi realizado em triplicata para observar a sugestiva micromorfologia de C. neoformans. Um teste de identificação confirmatória foi realizado pelo teste de produção de urease. Das 50 amostras examinadas, 16% (n = 8) foram positivas para C. neoformans e nos 10 bairros estudados, 60% (n = 6) foram positivos para o fungo. Os resultados mostraram que metade das amostras positivas foram encontradas em apenas dois bairros, sugerindo que a presença de C. neoformans em local público na cidade estudada pode ser considerada uma fonte potencial de infecção para humanos e animais.

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Clinical characteristics and prognosis of pediatric cryptococcosis in Beijing Children’s Hospital, 2002–2014

Cited by 13 publications

References 36 publications

Genotypic diversity and antifungal susceptibility of Cryptococcus neoformans isolates from paediatric patients in China

Genotypic diversity and antifungal susceptibility of Cryptococcus neoformans isolates from paediatric patients in China

Risk-Based Estimate of Human Fungal Disease Burden, China

Occurrence of Cryptococcus neoformans in the excreta of urban pigeons in the municipality of Redenção in Amazônia, Brazil

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