Chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes treated with sodium metabisulfite, a food preservative

Rencüzoğulları, Eyyüp; İla, Hasan Basri; Kayraldız, Ahmet; Topaktaş, Mehmet

doi:10.1016/s1383-5718(00)00142-x

Cited by 95 publications

(48 citation statements)

References 30 publications

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“…But high SCE frequency in C-X type chromosomes in our study does not confirm findings on high SCE frequency in DG type chromosomes of Yadav and Seth (1998). Our results demontrated the decrease of MI in treated patients compared with the control group, which is in a good accord in vitro studies associated with genotoxic agents tested on human peripheral lymphocytes (Celik & Aras, 2006;Aydemir et al, 2005;Rencuzogullari et al, 2001Rencuzogullari et al, , 2004Rupa et al,1989;Meng et al, 1994). The present study confirmed a link between the increasing Brought to you by | MIT Libraries Authenticated Download Date | 5/12/18 11:32 AM of SCE frequencies in cystic hydatid disease patients who were treated long-term by albendazole.…”

Section: Discussioncontrasting

confidence: 88%

Genotoxic effects of albendazole in patients medicated for cystic echinococcosis

et al. 2007

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57 SummaryCystic echinococcosis (CE) due to Echinococcus granulosus is one of the most important helminthic diseases in Turkey where it constitutes a public health and economic problems. Its mean annual incidence in humans is 4.4/100 000 and the prevalence of the tapeworm agent in domestic animals ranges from 11.2 to 50.7 %. Since 1980s, albendazole has been used for treatment of the disease, and this benzimidazole drug has been considered to be of relatively low toxicity. However, prolonged albendazole therapy of CE became to be a common practice, and data on possible genotoxic effects of the medication in humans are lacking. This study has concerned 17 women and 11 men, in total 28 patients with liver cystic hydatid complaints, who were administered albendazole (15 mg/kg) preoperatively (2 weeks) and postoperatively (6 months). Genotoxic effects of albendazole were searched using Sister Chromatid Exchange (SCE), mitotic index (MI) and chromosomal aberations (CAs) methods, comparing lymphocyte chromosomes of treated patients and a control group of healthy individuals. The results indicated a significant increase of SCE frequencies and decrease of MI in the treated group (p < 0.001). Regarding CAs, any difference between the groups was not determined.

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Section: Discussioncontrasting

confidence: 88%

Genotoxic effects of albendazole in patients medicated for cystic echinococcosis

et al. 2007

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“…These synthetic food additives were bound with the different lipid fractions to prevent the absorption of them including cholesterol through intestinal tract and their secretion in feces. The appearance or disappearance and increase or decrease of some lipid fractions which observed in the present work may be due to intestinal microflora (Rencuzogullari et al, 2001;Vally et al, 2009;Garcia-Gavin et al, 2012). These microorganisms have different biological systems for degradation or synthesis of lipids (Dawes and Sutherland, 1976;Jawetz et al, 1978;Brul and Coote, 1999;Tajkarimi et al, 2010) which may be altered synthetic food additives (Grasso et al, 1974;Combos, 1980 and1982;Maha, 1990;Zhang and Ma 2013).…”

Section: Synthetic Food Flavourantssupporting

confidence: 64%

Biochemical Changes in Fatty Acids, Hydrocarbons and Sterols as well as Total Lipids of Albino Rats Ingested some Synthetic Colourants and Flavourants as Food Additives

El-Beltagi

Abdel-Rahim

2017

Not Sci Biol

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The present study was carried out to investigate the effect of ingested synthetic food colourants or flavourants on total lipids content feces. The feces of rats ingested synthetic food colourants or flavourants has more lipids than that of control feces. In treated rat feces some fatty acids were disappeared (C 19 ) or appeared (C 14 ) while the other were increased (C 15 , C 20 , C 18:2 ) or decreased (C 6 ) when compared with the control feces. Most of unsaturated fatty acids (un SFA) might bind with the synthetic food colourants or flavourants and secreted in feces, but less consumed than saturated fatty acids (SFA) which, observed on hydrocarbon components, but sterols including cholesterol were more secreted by synthetic food additives treatments. Generally, the increase of total lipids and lipid fractions in feces such as unsaturated fatty acids (un SFA), total sterols (TS) especially cholesterol maybe due to their abilities to bind with food additives and form complex which secreted in feces.

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“…Stickiness has been attributed to the effect of pollutants and chemical compounds on the physical and chemical properties of DNA, protein or both, on the formation of complexes with phosphate groups in DNA, on DNA condensation or on formation of inter-and intra-chromatid cross links (Shahin & El-Amoodi, 1991;Rencüzoǧullari, et al, 2001;El-Ghamery et al, 2003;Gömürgen, 2005;T¨urkoglu, 2007). The presence of chromosome fragments is an indication of chromosome breaks, and can be a consequence of anaphase/telophase bridges (Sharma & Sen, 2002;Singh, 2003).…”

Section: Examination Of the Results Of Tests With Camellia Sinensis Inmentioning

confidence: 99%

Modulation of Mutagen-Induced Genotoxicity by two Lesotho Medicinal Plants in Allium cepa L

Asita¹,

Heisi²,

Tjale³

2015

ENRR

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Methanolic extracts (mg mL -1 ) of Dicoma anomala (0.0625, 0.125, 0.25), Chenopodium album (0.078, 0.156, 0.313), used in traditional medicine in Lesotho, and Camellia sinensis (0.1094, 0.2085, 0.44) were assessed for cytotoxicity, genotoxicity and modulation of Cyclophosphamide (CP 1.25 mg mL -1 ) -and EMS (0.25 mg mL -1 )-induced genotoxicity using the Allium cepa assay following 24 hours treatment. Cytotoxicity was measured by the mitotic index (MI). Genotoxicity (GT) was expressed as the number of aberrant mitotic cells per 100 mitotic cells. The MI and GT of test groups (triplicates), were compared with the negative (water) control group using t-test. Modulatory effect (ME) was calculated as, ME(%) = (1-(A-B)/(A-C) × 100) -1. A positive ME indicated an increase (synergism or potentiation) while a negative ME indicated a reduction (anti-genotoxicity) of mutagen-induced genotoxicity. The concentrations of D. anomala extract were cytotoxic and genotoxic. Mixtures of CP or EMS with the lower concentrations of D. anomala extract were more genotoxic than CP (250.50% increase) or EMS (149.74 and 157.37 % increase) or extracts alone. Only 0.313 mg mL -1 of C. album extract was cytotoxic but none of the three concentrations was genotoxic. Mixtures of CP with extracts of C.album were cytotoxic. CP-induced genotoxicity was reduced (55.18, 68.36, 57.40 %) and EMS-induced genotoxicity was also reduced by low concentrations (50.72, 61.13 %) of C.album extract. However, 0.313 mg mL -1 C. album extract increased (236.75%) EMS-induced genotoxicity. C. sinensis extracts and their mixtures with CP were not cytotoxic or genotoxic. CP-induced genotoxicity was reduced (63.61, 66.62, 78.64 %) but EMS-induced genotoxicity was increased (124.97, 4.48, 110.52 %) by C. sinensis extract.

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Chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes treated with sodium metabisulfite, a food preservative

Cited by 95 publications

References 30 publications

Genotoxic effects of albendazole in patients medicated for cystic echinococcosis

Genotoxic effects of albendazole in patients medicated for cystic echinococcosis

Biochemical Changes in Fatty Acids, Hydrocarbons and Sterols as well as Total Lipids of Albino Rats Ingested some Synthetic Colourants and Flavourants as Food Additives

Modulation of Mutagen-Induced Genotoxicity by two Lesotho Medicinal Plants in Allium cepa L

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