Modulation of Mutagen-Induced Genotoxicity by two Lesotho Medicinal Plants in Allium cepa L

Asita, Asita O.; Heisi, David H.; Tjale, Tumelo

doi:10.5539/enrr.v5n3p37

Cited by 7 publications

(11 citation statements)

References 83 publications

(83 reference statements)

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“…The following activities have been reported from D. anomala including anthelmintic [58,72], anticancer [66,70], antihyperglycemic [73,74], anti-inflammatory [47], antimicrobial [26,28,71,[75][76][77], antioxidant [26,71,74,78,79], antiplasmodial [66,80], hepatoprotective [56,79], toxicity, and cytotoxicity [68,71,74,80,81].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

“…The compound showed IC 50 value of 17.2 µM against 35.8 µM displayed by chloroquine [68]. Asita et al [81] evaluated the cytotoxicity, genotoxicity, and modulation of cyclophosphamide and ethyl methanesulfonate-induced genotoxicity of methanolic root extracts of D. anomala using the Allium cepa assay. The three concentrations (0.0625 mg/ml, 0.125 mg/ml, 0.25 mg/ml) of D. anomala tested were cytotoxic and genotoxic to the A. cepa root meristem cells.…”

Section: Toxicity and Cytotoxicitymentioning

confidence: 99%

“…The mixture of ethyl methane sulfonate at 0.25 mg/ml with each concentration of extract of D. anomala separately was genotoxic to the root tip meristem cells of A. cepa. These results suggest that the tested concentrations of root extracts of D. anomala exerted mitodepressive or cytotoxic effects on cell division of A. cepa root meristem cells [81]. Munodawafa et al [82] evaluated toxicity of D. anomala tuber using the brine shrimp (Artemia salina) toxicity bioassay test with Nerium oleander as positive control.…”

Section: Toxicity and Cytotoxicitymentioning

confidence: 99%

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Dicoma Anomala Sond.: A Review of Its Botany, Ethnomedicine, Phytochemistry and Pharmacology

Maroyi

2018

Asian J Pharm Clin Res

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Dicoma anomala is used as herbal medicine to treat and manage fever, coughs, colds, sore throats, abdominal pain, diarrhea, dysentery, constipation, intestinal worms, and sexually transmitted infections in tropical Africa. The aim of this study was to summarize the research that has been done on the ethnomedicinal uses, phytochemistry, and pharmacological properties of D. anomala in tropical Africa. The literature search for information on ethnomedicinal uses and pharmacological activities of D. anomala was undertaken using databases such as Web of Science, Scopus, Google Scholar, Science Direct, BioMed Central, PubMed, and Springer link. Other relevant literature sources included books, book chapters, websites, theses, conference papers, and other scientific publications. This study showed that D. anomala is used as herbal medicine in 57.1% of the countries in tropical Africa where it is indigenous. The species is used to treat 66 and five human and animal diseases, respectively. Several classes of secondary metabolites including acetylenic compounds, diterpene, flavonoids, phenols, phytosterols, saponins, sesquiterpenes, tannins and triterpenes have been isolated from D. anomala. Different aqueous and organic extracts of D. anomala exhibited anthelmintic, anticancer, antihyperglycemic, anti-inflammatory, antimicrobial, antioxidant, antiplasmodial, and hepatoprotective activities. The documented information on the botany, ethnomedicinal uses, phytochemistry, and pharmacological properties of D. anomala provide baseline data required for further ethnopharmacological studies on the species.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Section: Toxicity and Cytotoxicitymentioning

confidence: 99%

Section: Toxicity and Cytotoxicitymentioning

confidence: 99%

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Dicoma Anomala Sond.: A Review of Its Botany, Ethnomedicine, Phytochemistry and Pharmacology

Maroyi

2018

Asian J Pharm Clin Res

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“…The study revealed that silver nanoparticles conjugated sesquiterpene have antiparasitic activities against NF54 p. falciparum strain, and it exhibited anticancer properties by inducing oxidative damage in breast cancer cells. Asita and colleagues evaluated the modulation of D. anomala and Cyclophosphamide (CP) in mutagen induced genotoxicity [ 60 ].…”

Section: D Anomala and Pharmacological Studiesmentioning

confidence: 99%

Potential Treatment of Breast and Lung Cancer Using Dicoma anomala, an African Medicinal Plant

2020

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Globally, cancer has been identified as one of the leading causes of death in public health. Its etiology is based on consistent exposure to carcinogenic. Plant-derived anticancer compounds are known to be less toxic to the normal cells and are classified into acetylenic compounds, phenolics, terpenes, and phytosterols. Dicoma anomala is a perennial herb belonging to the family Asteraceae and is widely distributed in Sub-Saharan Africa and used in the treatment of cancer, malaria, fever, diabetes, ulcers, cold, and cough. This review aimed at highlighting the benefits of D. anomala in various therapeutic applications with special reference to the treatment of cancers and the mechanisms through which the plant-derived agents induce cell death.

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“…The assays were conducted according to the methods of Asita et al (2017) namely, preliminary dose selection assay to determine the concentrations of mutagens and hyraceum to use in the assays; cytotoxicity that is, mitotic index (MI), genotoxicity (GT) and the modulatory effect (ME) of hyraceum extract on mutagen-induced genotoxicity, including the root harvest, slide preparation and scoring of slides. In each assay, three root tips (triplicate) were assessed at each concentration.…”

Section: Procurement and Processing Of Hyraceummentioning

confidence: 99%

Evaluation of Procavia capensis hyraceum used in traditional medicine for modulation of mutagen-induced genotoxicity

Asita¹,

Rantsâ€TMo²,

Magama³

et al. 2018

J. Med. Plants Res.

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Hyraceum (HM) is used in traditional medicine in Southern Africa. Three concentrations of HM (mg/ml in distilled water) (0.0156, 0.03125 and 0.0625) were assessed for cytotoxicity (CT), genotoxicity (GT) and modulation of cyclophosphamide (CP)-and ethyl methanesulfonate (EMS)-induced GT using the Allium cepa assay following 24 h treatment. CP (1.00 mg/ml) and EMS (0.0375 mg/ml) were not cytotoxic but genotoxic. HM (0.03125, 0.0625 mg/ml) and its mixtures with CP or EMS induced significant reduction (p <0.05) of the mitotic index (MI) and were adjudged cytotoxic. HM alone and its mixtures with CP or EMS induced statistically significant genotoxicity (p < 0.05). Mixture of HM (0.016 mg/ml) with CP was not significantly more genotoxic than CP alone (ME 0.57). Each mixture of HM (0.03125, 0.0625 mg/ml) with CP was insignificantly less genotoxic than CP alone with modulatory effect (ME) of -0.14 and -0.01, respectively, which suggested no interaction between HM and CP. Mixtures of HM with EMS induced positive and significant (>2-fold) MEs and each mixture was significantly (p < 0.05) more genotoxic than HM or EMS alone which indicated a synergistic interaction. Sticky chromosomes, chromosome laggards, chromosome fragments, anaphase and telophase bridges, binucleate interphase cells were observed.

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Modulation of Mutagen-Induced Genotoxicity by two Lesotho Medicinal Plants in Allium cepa L

Cited by 7 publications

References 83 publications

Dicoma Anomala Sond.: A Review of Its Botany, Ethnomedicine, Phytochemistry and Pharmacology

Dicoma Anomala Sond.: A Review of Its Botany, Ethnomedicine, Phytochemistry and Pharmacology

Potential Treatment of Breast and Lung Cancer Using Dicoma anomala, an African Medicinal Plant

Evaluation of Procavia capensis hyraceum used in traditional medicine for modulation of mutagen-induced genotoxicity

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