Genotoxic effects of albendazole in patients medicated for cystic echinococcosis

Altıntaş, Nuray; Orenay, S.; Reyhan, Enver; Turk, Magdalena; AŞÇI>, Metin; Türel, Serkan; Yolasigmaz, A.; Altıntaş, Nazmiye

doi:10.2478/s11687-007-0004-x

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…In the light of studies which refer to adverse effects and high toxicity of anthelmintics to humans (Capleton et al 2006, Nuray et al 2007, Oztas et al 2007, there is a possibility of MRLs and ADIs re-evaluation. Food safety assessments are based on scientific data, which clearly has its limitations (Botsoglou and Fletouris 2000).…”

Section: Discussionmentioning

confidence: 99%

Anthelmintics residues in raw milk. Assessing intake by a children population

Tsiboukis¹,

Sazakli²,

Jelastopulu³

et al. 2013

Polish Journal of Veterinary Sciences

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Anthelmintics, such as benzimidazoles and probenzimidazoles, are veterinary drugs used against endoparasites in food producing animals. A number of these drugs are considered responsible for embryotoxicity and teratogenicity. The residue levels of Albendazole, Febantel, Fenbendazole, Mebendazole and some of their metabolites (Albendazole sulphoxide, Albendazole sulphone, Fenbendazole sulfone) were assessed in 123 (42 goat, 69 sheep, 12 bovine) raw milk samples collected from all farms throughout Southern Greece. Sample analysis was performed by HPLC with Diode Array Detector. A high percentage (27.6%) of the samples examined was found to be positive for the investigated compounds. In 14 samples (11.4%), the residues' concentration exceeded the established Maximum Residue Limits.Estimated Daily Intakes were calculated for a population of 723 children aged 10-12 years. Data on milk consumption were obtained by personal interview through a 7-day food frequency questionnaire. The maximum Estimated Daily Intakes for the anthelmintic residues, concerning raw milk, did not exceed the current Acceptable Daily Intake.

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Section: Discussionmentioning

confidence: 99%

Anthelmintics residues in raw milk. Assessing intake by a children population

Tsiboukis¹,

Sazakli²,

Jelastopulu³

et al. 2013

Polish Journal of Veterinary Sciences

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“…Experiments were carried out on male BALB/c mice (n=165) weighing 20-25 g. Mice were randomly divided into five groups as follows: Group 5 -E. multilocularis infected (as Group 2) and treated with combination of TF and ABZ as above Samples of blood, spleen, and peritoneal macrophages were obtained at the following weeks: 0 (prior infection), 2,4,6,8,10,12,14,18,22, and 26 p.i. from all groups (3 mice per experimental day).…”

Section: Experimental Designmentioning

confidence: 99%

“…The disadvantage of benzimidazoles consists also in irresponsiveness to treatment in some patients and recurrence of the disease after intermission of the therapy [8]. There is still no consensus regarding the effective dosage and duration of treatment [9,10]. Moreover, the immunological status of the host, host susceptibility, and actual stage of infection influence the results of treatment [11].…”

Section: Introductionmentioning

confidence: 99%

Immunotherapy Can Enhance Anthelmintic Efficacy in Alveolar Echinococcosis

Dvorožnáková

2015

Current Topics in Echinococcosis

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The immune response of the intermediate host with alveolar echinococcosis was investigated on mice intraperitoneally infected with Echinococcus multilocularis protoscoleces. The study was focused on cell-mediated immune response (dependent on interactions of T lymphocytes and macrophages), which is considered protective in alveolar echinococcosis. The immune response to E. multilocularis is regulated by Th1/Th2 cytokines produced by the CD4+ T lymphocyte subpopulation. Metacestode has been known for its ability to modify immune functions and suppress effective specific cell response to ensure its survival in host organism. The influence of immunomodulatory substances -muramyltripeptide (L-MTP-PE), glucan (GI), glucan with zinc (GIZn), and transfer factor (TF) -applied alone or combined with anthelmintic albendazole (ABZ) on regulative and effector components of immunity were tested and at the same time, antiparasitic efficacy of immunomodulators was evaluated.

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Imunomodulative effect of liposomized muramyltripeptide phosphatidylethanolamine (L-MTP-PE) on mice with alveolar echinococcosis and treated with albendazole

2008

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The effect of liposomized muramyltripeptide phosphatidylethanolamine (L-MTP-PE) administered separately or with anthelmintic albendazole (ABZ) on cellular immunity of mice with alveolar echinococcosis was studied. The proliferative activity of splenic T and B lymphocytes was the most stimulated after combined L-MTP-PE + ABZ therapy [from weeks 8 to 14 post-infection (p.i.)] that also induced a long-term development of protective Th1 response (the highest serum concentration of IFN-gamma from weeks 8 to 18 p.i.). On the contrary, Th2 response (cytokine IL-5) in infected mice treated with L-MTP-PE was inhibited since week 8 p.i., but a significant long-term decrease in IL-5 concentration was found after combined L-MTP-PE+ABZ therapy until the end of the experiment (until week 26 p.i.). L-MTP-PE stimulated the production of superoxide anion (O2-) by peritoneal macrophages from weeks 8 to 12 p.i., but the highest O2- production was accordingly recorded after therapy L-MTP-PE+ABZ from weeks 8 to 18 p.i. Stimulation of cellular immunity of mice with alveolar echinococcis with L-MTP-PE and an interaction with ABZ's anti-parasitic effect resulted in the greatest and long-term reduction of growth of Echinococcus multilocularis cysts in the host from week 10 p.i. until the end of the experiment.

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Genotoxic effects of albendazole in patients medicated for cystic echinococcosis

Cited by 6 publications

References 35 publications

Anthelmintics residues in raw milk. Assessing intake by a children population

Anthelmintics residues in raw milk. Assessing intake by a children population

Immunotherapy Can Enhance Anthelmintic Efficacy in Alveolar Echinococcosis

Imunomodulative effect of liposomized muramyltripeptide phosphatidylethanolamine (L-MTP-PE) on mice with alveolar echinococcosis and treated with albendazole

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