“…33 One of the strategies to controlled release of drugs should be to distribute the drug within 34 a substrate with special chemical, biological, and mechanical characteristics such as chitosan 35 [4,7] alginate [8] chitosan-montmorillonite [9] chitosan-LDH [10] and so on. Chitosan, due to its 36 numerous hydroxyl and amine functionalities and biocompatibility, biodegradability, and 37 haemostatic properties, has been used frequently in drug delivery systems [4,7,9,10]. 38 In addition, use of coatings in medical applications has proven adding various structural 39 and mechanical properties to drug composites such as protection from oxidation and degradation 40 of drug, delay in the release of drug, changing from injection to oral drug use, etc [11][12][13][14].…”