Nanohybrid organic–inorganic chitosan/dopamine/TiO2 composites with controlled drug-delivery properties

Safari, Mehdi; Ghiaci, Mehran; Jafari-Asl, Mehdi; Ensafi, Ali A.

doi:10.1016/j.apsusc.2015.03.028

Cited by 48 publications

(14 citation statements)

References 40 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alex et al [67] mentioned that TiO 2 -CS-Chondroitin 4-sulphate composite exhibited great potential for bone implant applications because it showed excellent bioactivity, biocompatibility and high cell viability at low concentrations on human MG-63 cell line. Likewise, Safari et al [103] evaluated the in vitro drug-delivery properties of a CS/dopamine(DOP)/TiO 2 system (the solution was at pH 7.4) and concluded that the incorporation of TiO 2 on a CS/DOP system enhanced the drug entrapment, and provided a controlled drug-release effect (16 h) compared with CS/DOP system (10 min). This fact was attributable to the strong hydrogen bonding interactions between CS/DOP systems with -OH groups on the TiO 2 surface.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Chitosan-TiO2: A Versatile Hybrid Composite

et al. 2020

View full text Add to dashboard Cite

In recent years, a strong interest has emerged in hybrid composites and their potential uses, especially in chitosan-titanium dioxide (CS-TiO 2 ) composites, which have interesting technological properties and applications. This review describes the reported advantages and limitations of the functionalization of chitosan by adding TiO 2 nanoparticles. Their effects on structural, textural, thermal, optical, mechanical, and vapor barrier properties and their biodegradability are also discussed. Evidence shows that the incorporation of TiO 2 onto the CS matrix improves all the above properties in a dose-dependent manner. Nonetheless, the CS-TiO 2 composite exhibits great potential applications including antimicrobial activity against bacteria and fungi; UV-barrier properties when it is used for packaging and textile purposes; environmental applications for removal of heavy metal ions and degradation of diverse water pollutants; biomedical applications as a wound-healing material, drug delivery system, or by the development of biosensors. Furthermore, no cytotoxic effects of CS-TiO 2 have been reported on different cell lines, which supports their use for food and biomedical applications. Moreover, CS-TiO 2 has also been used as an anti-corrosive material. However, the development of suitable protocols for CS-TiO 2 composite preparation is mandatory for industrial-scale implementation.Materials 2020, 13, 811 2 of 27 they are synthesized by different methods (intercalation of the polymer, sol-gel, hydrothermal, electro-deposition, chemical and physical vapor deposition, suspension and liquid phase deposition). These methods are effective to enhance the technological and mechanical properties of each individual component and also reveal new functionalities [1,3]. Currently, there is a special interest in combining natural polymers such as chitosan (CS) with inorganic materials like titanium dioxide (TiO 2 ) to obtain hybrid composites (CS-TiO 2 ) with beneficial properties [3][4][5][6].Chitosan (CS) is a natural biopolymer (linear polysaccharide comprising 1-4 linked 2-amino-deoxy-β-D-glucan) generally obtained by deacetylation of chitin, the main structural component of crustacean exoskeletons. CS exhibits a poly-cationic character and is non-toxic and biodegradable [7]. CS is considered a biological functional compound with multiple interesting properties. It can form films for food and pharmaceutical applications, including edible coatings, packaging material, or as drug-eluting carrier [5,7]. Its adsorbent capacity can have environmental applications during photocatalytic processes of waste-water treatment [8], and it also has inherent antibacterial and antifungal properties [9]. It is biocompatible with several organic and inorganic compounds by the presence of free amino and hydroxyl functional groups in its structure, which can react with other functional groups by electrostatic forces, hydrogen bonds, or by compound-soak up into the polymeric matrix, thus improving its mechanical and biological properties [10]...

show abstract

Section: Biomedical Applicationsmentioning

confidence: 99%

Chitosan-TiO2: A Versatile Hybrid Composite

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The most studied applications are antibacterial activity [13] and water pollutant degradation [14]. Biomedical applications of CST have also been widely investigated [15]. Furthermore, CST films have been applied for fruit preservation [16].…”

Section: Introductionmentioning

confidence: 99%

Effect of Mixed Oxide-Based TiO2 on the Physicochemical Properties of Chitosan Films

Anaya-Esparza

Vargas‐Torres

Palma‐Rodríguez

et al. 2022

Period. Polytech. Chem. Eng.

View full text Add to dashboard Cite

The physicochemical, mechanical, and structural properties of chitosan-based films (CS) alone or CS-films with mixed oxide nanoparticles (TiO2-ZnO-MgO, TZM; CSTZM) at different concentrations (125, 250, and 500 μg mL−1) were investigated. The addition of nano-TZM promoted a color change (from colorless to white) in the film-forming solution, which increased its turbidity and it decreased viscosity. CSTZM were semitransparent (transmittance, T% decreased up to 49%) compared to CS-based films (T% = 95.5). CSTZM (particularly at a concentration of 500 μg mL−1) exhibited an improvement in the moisture content (decreased from 12.6 to 9.67%), water solubility (decreased from 14.94 to 10.22%), degree of swelling (increased from 19.79 to 36.28%), water vapor barrier (decreased from 6.62 x 10−16 to 4.33 x 10−16 g m−1 h−1 Pa−1), thermal stability (the endotherm peak increased from 99.5 to 157.7 °C), and mechanical properties (tensile strength and elongation at break increased from 4.15 to 4.98 kPa and 6.96 to 56.18%, respectively, while the modulus of elasticity decreased from 144 kPa to 4.11 kPa), without toxicity effects on Artemia salina (93.33% survival). X-ray diffraction and Fourier transform infrared studies demonstrated an interaction between CS-based films and nano-TZM. Overall, this film exhibited great potential for diverse industrial applications.

show abstract

“…Organic/inorganic hybrid materials have attracted ever increasing attention in recent years due to their unique structural characteristics and potential applications in bioseparation, 1 targeted drug/ gene delivery, 2,3 theranostics and more. 4 Typically, hybrid particles are composed of inorganic cores and surrounding organic layers in the form of polymer shells or polymer brushes.…”

Section: Introductionmentioning

confidence: 99%