Porous Polylactic Acid-Silica Hybrids: Preparation, Characterization, and Study of Mesenchymal Stem Cell Osteogenic Differentiation

Pandis, C.; Trujillo, Sara; Matos, Joana; Madeira, S.; Ródenas-Rochina, Joaquín; Kripotou, S.; Kyritsis, Apostolos; Mano, João F.; Ribelles, J.L. Gómez

doi:10.1002/mabi.201400339

Cited by 7 publications

(7 citation statements)

References 36 publications

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“…Besides, silica nanoparticles can interact with DL-lactide through their silanol groups. In another study [ 53 ], the silica was functionalized with TEOS and GOPTMS through graft-condensation reaction. Afterward, the functionalized silica was melt-mixed with PLA by reactive extrusion technique.…”

Section: Rheological Propertiesmentioning

confidence: 99%

A Review on Synthesis, Properties, and Applications of Polylactic Acid/Silica Composites

Kaseem

Rehman

Hossain³

et al. 2021

Polymers

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Polylactic acid (PLA)/silica composites as multifunctional high-performance materials have been extensively examined in the past few years by virtue of their outstanding properties relative to neat PLA. The fabrication methods, such as melt-mixing, sol–gel, and in situ polymerization, as well as the surface functionalization of silica, used to improve the dispersion of silica in the polymer matrix are outlined. The rheological, thermal, mechanical, and biodegradation properties of PLA/silica nanocomposites are highlighted. The potential applications arising from the addition of silica nanoparticles into the PLA matrix are also described. Finally, we believe that a better understanding of the role of silica additive with current improvement strategies in the dispersion of this additive in the polymer matrix is the key for successful utilization of PLA/silica nanocomposites and to maximize their fit with industrial applications needs.

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Section: Rheological Propertiesmentioning

confidence: 99%

A Review on Synthesis, Properties, and Applications of Polylactic Acid/Silica Composites

Kaseem

Rehman

Hossain³

et al. 2021

Polymers

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“…In order for congruent degradation to occur, some covalent bonds are needed between the organic and inorganic components (Figure 5 A). Examples are silica/natural polymers: e.g., silica/gelatin (Ren et al, 2002 ; Mahony et al, 2010 , 2014 ), silica/poly(gamma-glutamic acid) (Poologasundarampillai et al, 2010 , 2012 , 2014 ; Valliant et al, 2013 ), silica/chitosan (Shirosaki et al, 2005 , 2010 ; Connell et al, 2014 ), silica/polyester (Rhee et al, 2002 , 2004 ; Pandis et al, 2015 ), and silica/PEG (Liu et al, 2012 ; Russo et al, 2013 ; Catauro et al, 2015 ; Li et al, 2015 ). The foaming method (Figure 5 B) can be introduced to the sol–gel hybrid process (Mahony et al, 2010 , 2014 ) or the sol to gel transition can be used to 3-D print the hybrids (Gao et al, 2013 ).…”

Section: Era Of Innovation (2005–2025) Frontiers and Unmet Challengesmentioning

confidence: 99%

Bioactive Glasses: Frontiers and Challenges

Hench

Jones

2015

Front. Bioeng. Biotechnol.

287

187

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Bioactive glasses were discovered in 1969 and provided for the first time an alternative to nearly inert implant materials. Bioglass formed a rapid, strong, and stable bond with host tissues. This article examines the frontiers of research crossed to achieve clinical use of bioactive glasses and glass–ceramics. In the 1980s, it was discovered that bioactive glasses could be used in particulate form to stimulate osteogenesis, which thereby led to the concept of regeneration of tissues. Later, it was discovered that the dissolution ions from the glasses behaved like growth factors, providing signals to the cells. This article summarizes the frontiers of knowledge crossed during four eras of development of bioactive glasses that have led from concept of bioactivity to widespread clinical and commercial use, with emphasis on the first composition, 45S5 Bioglass®. The four eras are (a) discovery, (b) clinical application, (c) tissue regeneration, and (d) innovation. Questions still to be answered for the fourth era are included to stimulate innovation in the field and exploration of new frontiers that can be the basis for a general theory of bioactive stimulation of regeneration of tissues and application to numerous clinical needs.

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“…In previous works, we have proposed a novel strategy for the preparation of hybrid porous materials performing sol–gel reactions using silica precursors inside the pores of polymeric high‐interconnected porous membranes, obtaining a homogeneous thin layer upon the pore walls of the membrane . The silica layer deposited highly reinforced the polymer, for that reason we also produced a tuneable reinforced hybrid material filling the pores of the membrane with a blend of chitosan–silica network .…”

Section: Introductionmentioning

confidence: 99%

Organic-inorganic bonding in chitosan-silica hybrid networks: Physical properties

Trujillo

Pérez-Román

Kyritsis

et al. 2015

J. Polym. Sci. Part B: Polym. Phys.

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Novel biomaterials are needed for bone tissue repair with improved mechanical performance compared to classical bioceramics. The objective of this work was to characterize a hybrid filler material, which is capable to coat as a thin film porous scaffolds improving their mechanical properties for bone tissue engineering. The hybrid filler material is a blend of chitosan and silica network formed through in situ sol–gel using tetraethylortosilicate and 3‐glycidoxypropyltrimethoxysilane (GPTMS) as silica precursors. The hypothesis was that the epoxy ring of GPTMS could react with the amino groups of chitosan in acidic media while it is also reacting the siloxane groups of hydrolyzed silica precursors. The formation of the hybrid organic–inorganic network was assessed by different physical techniques revealing changes in molecular mobility and hydrophilicity upon chemical reaction. Finally, the cytotoxicity of the samples was also evaluated by MTT assay. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015, 53, 1391–1400

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Porous Polylactic Acid-Silica Hybrids: Preparation, Characterization, and Study of Mesenchymal Stem Cell Osteogenic Differentiation

Cited by 7 publications

References 36 publications

A Review on Synthesis, Properties, and Applications of Polylactic Acid/Silica Composites

A Review on Synthesis, Properties, and Applications of Polylactic Acid/Silica Composites

Bioactive Glasses: Frontiers and Challenges

Organic-inorganic bonding in chitosan-silica hybrid networks: Physical properties

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