Chemotherapeutic effects of Apigenin in breast cancer: Preclinical evidence and molecular mechanisms; enhanced bioavailability by nanoparticles

Adel, Moein; Zahmatkeshan, Masoumeh; Akbarzadeh, Abolfazl; Rabiee, Navid; Ahmadi, Sepideh; Keyhanvar, Peyman; Rezayat, Seyed Mahdi; Seifalian, Alexander M.

doi:10.1016/j.btre.2022.e00730

Cited by 23 publications

(8 citation statements)

References 111 publications

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“…So far, in vitro and in vivo studies have reported the mechanism of apigenin in inhibiting the development of breast cancer cells. These mechanisms include the induction of apoptosis and cell cycle arrest, inhibition of fatty acid synthase, aromatase, tumor angiogenesis, and anti-invasive metastases [43]. In addition, the anticancer activity of an extract is related to its ability as an antioxidant.…”

Section: Discussionmentioning

confidence: 99%

Biological Activity of Celery Extract Using Different Extraction Methods

Septiana¹,

Rahmawati²,

Izzati³

et al. 2023

Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)

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Celery is a medicinal plant that is widely used as an ingredient in traditional medicine in Indonesia. Scientifically, celery extract has the ability as an antioxidant, antibacterial, anti-breast cancer, and inhibiting ACE enzyme activity as antihypertensive. The use of maceration and ultrasound-assisted extraction (UAE) methods will give different results on the amount and biological activity of the extract. This study aims to determine the biological activity of celery extract using maceration and ultrasound-assisted extraction method. TEAC, FRAP, NO, and DPPH scavenging assays were used to determine in vitro antioxidant activities. Folin-Ciocalteu reagent and aluminium chloride colorimetric assay were used to determine total phenolic and flavonoid contents, respectively. The sulforhodamine B and angiotensin-converting enzyme (ACE) inhibition assays were used to determine anti-breast cancer and antihypertensive activities, respectively. The celery extract from both extraction methods had antioxidants activity, inhibited the growth of MDA-MB-231 breast cancer cell line, and showed as antihypertensive by ACE inhibition. The maceration gave better activities than UAE with significant results in antioxidants, especially in a water solvent. The use of solvents had more effect on antioxidant activity, especially the FRAP and DPPH free radical scavenging method, as well as the TPC and TFC values of the extract compared to the extraction technique. It was found that ethanol solvent was better than water. The maceration provided better activities than ultrasound-assisted extraction in antibreast cancer. However, there was no significant difference in antihypertensives. The UAE extraction method produced higher yields but had lower antioxidant and anticancer activity than a maceration.

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Section: Discussionmentioning

confidence: 99%

Biological Activity of Celery Extract Using Different Extraction Methods

Septiana¹,

Rahmawati²,

Izzati³

et al. 2023

Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)

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“…Besides, apigenin also exerts cytotoxic activity in BC cells [61] and the chemotherapeutic effects of apigenin in BC have been demonstrated. [62] Luteolin is a representative of a natural flavonoid that has been proven to modulate various signaling pathways involved in cancer and depression development. It was revealed to be beneficial for BC and depression.…”

Section: Discussionmentioning

confidence: 99%

Molecular basis of breast cancer with comorbid depression and the mechanistic insights of Xiaoyaosan in treating breast cancer-associated depression

Chen

2023

Medicine

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Depression and breast cancer (BC) have been found to have a shared genetic basis, multiple loci of effect, and a presumed causal relationship. The treatment of BC combined with depression poses significant challenges. This study aims to use bioinformatics and network pharmacology to explore the molecular basis of BC combined with depression and to elucidate the potential mechanisms of Xiaoyaosan (XYS) in treating this disease. The molecular background of BC complicated with depression was discovered via data mining and bioinformatics. The molecular mechanism of XYS in the treatment of BC with depression was investigated by network pharmacology. The binding affinity between targets and active compounds was evaluated by molecular docking. The impact of XYS on the gene and protein expression of matrix metallopeptidase 9 (MMP9) in microglial cells was assessed using RT-quantitative PCR and western blot analysis, respectively. Differential expression analysis was conducted to identify genes associated with BC, revealing that 2958 genes were involved, with 277 of these genes also being related to depression. XYS was found to contain 173 active compounds and 342 targets, with 44 of these targets being involved in regulating the progression of BC and depression. Enrichment analysis was performed to identify pathways associated with these targets, revealing that they were related to cell proliferation, catalytic activity, cell communication, and interleukin-18 signaling and LXR/RXR activation. Network analysis was conducted to identify key targets of Xiaoyaosan in treating BC combined with depression, with EGF, interleukin 6, epidermal growth factor receptor, and peroxisome proliferator activated receptor gamma being identified as important targets. Molecular docking was also performed to assess the binding affinity between key targets and active compounds, with puerarin showing the strongest affinity for MMP9. In microglial cells, XYS significantly enhances the gene and protein expression of MMP9. This study elucidated the pharmacological mechanism of co-treatment for BC patients complicated with depression and the pharmacological mechanism of XYS against BC plus depression.

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“…Many clinical trials on the nano-apigenin showed remarkable activity against different types of cancers [73]. Nano designing could also be used to enhance the solubility and bioavailability profile of apigenin, which showed promising results against breast cancer cell growth [74].…”

Section: Nano-apigeninmentioning

confidence: 99%

Nanodelivery of Dietary Polyphenols for Therapeutic Applications

Rudrapal¹,

Mishra

Rani

et al. 2022

Molecules

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Advancement in nanotechnology has unleashed the therapeutic potentials of dietary polyphenols by enhancing bioavailability, improving biological half-life, and allowing site-specific drug delivery. In this review, through citation of relevant literature reports, we discuss the application of nano-pharmaceutical formulations, such as solid lipid nanoparticles, nano-emulsions, nano-crystals, nano-polymersomes, liposomes, ethosomes, phytosomes, and invasomes for dietary polyphenols. Following this, we highlight important studies concerning different combinations of nano formulations with dietary polyphenols (also known as nanophytopolyphenols). We also provide nano-formulation paradigms for enhancing the physicochemical properties of dietary polyphenols. Finally, we highlight the latest patents that were granted on nano-formulations of dietary polyphenols. Based on our review, we observe that nanosized delivery of herbal constituents, spices, and dietary supplements have the ability to improve biological processes and address issues connected with herbal treatments.

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Chemotherapeutic effects of Apigenin in breast cancer: Preclinical evidence and molecular mechanisms; enhanced bioavailability by nanoparticles

Cited by 23 publications

References 111 publications

Biological Activity of Celery Extract Using Different Extraction Methods

Biological Activity of Celery Extract Using Different Extraction Methods

Molecular basis of breast cancer with comorbid depression and the mechanistic insights of Xiaoyaosan in treating breast cancer-associated depression

Nanodelivery of Dietary Polyphenols for Therapeutic Applications

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