Chemical composition and anticancer, antiinflammatory, antioxidant and antimalarial activities of leaves essential oil of Cedrelopsis grevei

Afoulous, Samia; Ferhout, Hicham; Raoelison, Emmanuel Guy; Valentin, Alexis; Moukarzel, Béatrice; Couderc, François; Bouajila, Jalloul

doi:10.1016/j.fct.2013.02.008

Cited by 108 publications

(54 citation statements)

References 37 publications

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“…However no studies are available on biological activities of ocimene but recent reports suggests ocimene could be associated with antioxidant, antifungal, anti-parasitic, anticancer, antibacterial and wound healing activities of ocimene rich essential oils [13] [21]- [25]. Farnesene produced by plants in response to insect attack reported to inhibit growth of eukaryotic (like insects, parasites) as well as prokaryotic pathogens and exhibit anticancer, anti-plasmodial, hepatoprotective, antioxidant, anti-inflammatory activity [34]- [40]. Camphene a monoterpene used in flavour and fragrance, reported to inhibit sterol biosynthesis by inhibiting sterol regulatory element-binding protein (SREBP)-1c, SREBP-2, 3-hydroxy-3 methyl-glutaryl-CoA reductase (HMGCR) in eukaryotic cells [41]- [50].…”

Section: Discussionmentioning

confidence: 99%

Effects of Cinnamaldehyde, Ocimene, Camphene, Curcumin and Farnesene on <i>Candida albicans</i>

Thakre¹,

Mulange²,

Kodgire³

et al. 2016

AiM

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Efficacy of five plant molecules against thirty three clinical isolates and two standard strains of C. albicans, differentially susceptible to fluconazole (FLC) is tested in this study. Effect on biofilm (adhesion, development and maturation) formation, morphogenesis and synergy with fluconazole (FLC) against a FLC resistant strain of Candida albicans ATCC 10231 is also evaluated. All the plant molecules tested were equally effective against isolates and strains of C. albicans (N = 35) tested in this study. Cinnamaldehyde was found most effective against planktonic growth followed by ocimene. Both the molecules exhibited fungicidal activity and killed 99.9% of inoculum within 80 and 20 min of exposure respectively at 0.62 mM and 176.8 mM concentrations. Curcumin (5 -20 mM), camphene (8 -32 mM) and farnesene (25 -100 mM), although inhibited planktonic growth, were fungistatic. All the five plant molecules tested in this study inhibited morphogenesis significantly and exhibited considerable activity against biofilm formation. Inhibition of biofilm was found to be stage specific i.e. efficacy was more against adhesion followed by developing and mature biofilm. Plant molecules tested exhibited excellent synergy with fluconazole. However FIC index values 0.155, 0.062 and 0.046 indicate that ocimene was the most effective synergistic molecule inhibited planktonic growth, developing biofilm and mature biofilm growth respectively at very low concentrations. This is the first report of anti-Candida activity of three terpenoids viz. ocimene, farnesene and camphene against planktonic & biofilm growth, morphogenesis as well as synergy with FLC. Plant molecules tested in this study may find use in antifungal chemotherapy individually and or in a combination with FLC.

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Section: Discussionmentioning

confidence: 99%

Effects of Cinnamaldehyde, Ocimene, Camphene, Curcumin and Farnesene on <i>Candida albicans</i>

Thakre¹,

Mulange²,

Kodgire³

et al. 2016

AiM

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“…There are more than 10,000 kinds of sesquiterpenes (Davıs and Croteau 2000). They have long been investigated for biological activities; anticarcinogenic (Afoulous et al 2013), antimicrobial (Wang et al 2013), antifungal (Kundu et al 2013), anti-inflammatory (Wang et al 2013), and, more recently, antioxidant (Abolaji et al 2013) activities.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and genotoxicity of zingiberene on different neuron cell lines in vitro

et al. 2014

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The main objective of this study is to investigate the cytotoxic, genotoxic and antioxidant properties of zingiberene (ZBN) in an in vitro rat brain cell culture study. The cytotoxic effect was determined against the rat neuron and N2a neuroblastoma (N2a-NB) cell lines using the 3,(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, while the antioxidant activity was assessed using the total antioxidant capacity (TAC) and total oxidative stress (TOS) assays. The effects on DNA damage were also evaluated in this study by the single cell gel electrophoresis assay. The results indicated that ZBN has an anti-proliferative activity suppressing the proliferation of N2a-NB cells at concentrations over 50 mg L -1 and neuron cells at concentrations over 150 mg L -1. In addition, ZBN treatments at higher doses (B50 mg L -1 ) led to increases of TOS levels in N2a-NB cell cultures. However 25 mg L -1 of ZBN treatment caused increases of TAC levels in cultured neuron and N2a-NB cell cultures while ZBN at doses of 10-400 mg L -1 did not increase the number of total damage score in both cell lines. This study clearly indicates that ZBN has a significant potential to be used as a natural anticancer agent in cultured N2a-NBs.

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“…Phenolic constituents in plant essential oils showed antioxidant activity in many studies. This activity is due to their ability to scavenge free radicals (4)(5)(6)(7). In addition, complex factors such as the nature of the antioxidants, the condition of oxidation, and the properties of the substrate are related to the activity of antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cytotoxic, membrane, and DNA damaging effects of Thymus revolutus Célak essential oil on different cancer cells

Özkan¹,

Erdoğan²

2017

Turk J Med Sci

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Background/aim: In this study, we evaluated Thymus revolutus Célak essential oil and its two main constituents, γ-terpinene and p-cymene, as potential oxidative agents against lung cancer and epidermoid carcinoma cells. Materials and methods:Cell viability assessment was made by CellTiter-Blue® cell viability and 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide (MTT) assay after treatment with 5-600 µg/mL concentrations of essential oil, γ-terpinene, and p-cymene. Malondialdehyde and 8-hydroxy-2′-deoxyguanosine levels in parental H1299, epirubicin-resistant (drug-resistant) H1299, A549, and A431 cells were also assayed after essential oil, γ-terpinene, and p-cymene had been administered for 24 h. Glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GRx), and glucose 6-phosphate dehydrogenase (G6PD) activities were determined.Results: Parental H1299 cells were found to be more sensitive to the cytotoxic effects of all compounds. While A431 cells had the highest membrane damage, which was caused by essential oil (IC 50 and IC 70 ), A549 cells had the highest DNA damage at IC 50 and IC 70 p-cymene concentrations. G6PD, GST, GRx, and GPx enzyme activities of cells, which increased against these compounds, depended on concentrations, incubation times, and antioxidant capacities of the cells. Conclusion:This study suggests that different cancer cells showed different cellular responses against potential antitumor and prooxidative effects of the essential oil and its two main constituents.

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Chemical composition and anticancer, antiinflammatory, antioxidant and antimalarial activities of leaves essential oil of Cedrelopsis grevei

Cited by 108 publications

References 37 publications

Effects of Cinnamaldehyde, Ocimene, Camphene, Curcumin and Farnesene on <i>Candida albicans</i>

Effects of Cinnamaldehyde, Ocimene, Camphene, Curcumin and Farnesene on <i>Candida albicans</i>

Cytotoxicity and genotoxicity of zingiberene on different neuron cell lines in vitro

Evaluation of cytotoxic, membrane, and DNA damaging effects of Thymus revolutus Célak essential oil on different cancer cells

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Chemical composition and anticancer, antiinflammatory, antioxidant and antimalarial activities of leaves essential oil of Cedrelopsis grevei

Cited by 108 publications

References 37 publications

Effects of Cinnamaldehyde, Ocimene, Camphene, Curcumin and Farnesene on &lt;i&gt;Candida albicans&lt;/i&gt;

Effects of Cinnamaldehyde, Ocimene, Camphene, Curcumin and Farnesene on &lt;i&gt;Candida albicans&lt;/i&gt;

Cytotoxicity and genotoxicity of zingiberene on different neuron cell lines in vitro

Evaluation of cytotoxic, membrane, and DNA damaging effects of Thymus revolutus Célak essential oil on different cancer cells

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Product

Resources

About

Effects of Cinnamaldehyde, Ocimene, Camphene, Curcumin and Farnesene on <i>Candida albicans</i>

Effects of Cinnamaldehyde, Ocimene, Camphene, Curcumin and Farnesene on <i>Candida albicans</i>