2014
DOI: 10.1007/s10616-014-9729-9
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: The main objective of this study is to investigate the cytotoxic, genotoxic and antioxidant properties of zingiberene (ZBN) in an in vitro rat brain cell culture study. The cytotoxic effect was determined against the rat neuron and N2a neuroblastoma (N2a-NB) cell lines using the 3,(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, while the antioxidant activity was assessed using the total antioxidant capacity (TAC) and total oxidative stress (TOS) assays. The effects on DNA damage were also eva… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

1
10
0

Year Published

2015
2015
2022
2022

Publication Types

Select...
6
1

Relationship

1
6

Authors

Journals

citations
Cited by 20 publications
(11 citation statements)
references
References 47 publications
1
10
0
Order By: Relevance
“…These results conducted to previous studies investigated the cytotoxic effect of GYZ and azulene derivate toward gingival fibroblast, pulp cell, periodontal ligament fibroblast and human tumor cell lines including submandibular gland carcinoma, oral squamous cell carcinoma (HSC-2, HSC-3), promyelocytic leukemia (HL-60 [ 11 , 24 ]. Our findings are also in agreement with the results that have reported that zingiberene (a monocyclic sesquiterpene)exhibited strong antiproliferative effect against N2a-NB cell line by MTT assay [ 7 ]. In addition, Turkez et al .…”
Section: Discussionsupporting
confidence: 93%
See 2 more Smart Citations
“…These results conducted to previous studies investigated the cytotoxic effect of GYZ and azulene derivate toward gingival fibroblast, pulp cell, periodontal ligament fibroblast and human tumor cell lines including submandibular gland carcinoma, oral squamous cell carcinoma (HSC-2, HSC-3), promyelocytic leukemia (HL-60 [ 11 , 24 ]. Our findings are also in agreement with the results that have reported that zingiberene (a monocyclic sesquiterpene)exhibited strong antiproliferative effect against N2a-NB cell line by MTT assay [ 7 ]. In addition, Turkez et al .…”
Section: Discussionsupporting
confidence: 93%
“…[ 19 ] reported that the alpha-copaene did not induce genotoxicity in cultured neuron cell lines. In addition, zingiberene did not induce genotoxic damage in cultured neuron and N2a-NB cells [ 7 ]. Furthermore, in our recently published paper, using the SCGE assay, we have demonstrated that tricyclic sesquiterpene a-copaene has neither genotoxic nor mutagenic effect neuron and N2a-NB cells [ 8 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Ginger oil also had antifungal activity [ 35 ], and ginger essential oil inhalation has implications for alleviating postoperative nausea and vomiting in abdominal surgery patients [ 36 ]. Additionally, zingiberene and sesquiphellandrene has anticancer potential [ 37 , 38 ]. Above all, the terpenes introduced from ginger juice in GRC during the processing may enhance the antimicrobial activity and antioxidant activity of RC and bring new pharmacological activities to RC.…”
Section: Resultsmentioning
confidence: 99%
“…Plants and animals use VOCs for chemical communication, and plants also use them for defense against herbivory and in the production of fragrances for pollinator attraction (Raguso and Pichersky, ; Raguso, , ; Arimura et al., ; Lucas‐Barbosa et al., ; Schiestl and Johnson, ; Duffy et al., ). The presence of VOCs has also been proposed as an important indicator of phytochemicals that may be critical in drug discovery (Guo et al., ; Togar et al., ). In the past two decades, human‐made VOCs such as benzene, carbon monoxide, and formaldehyde have been in the news due to their toxic and hazardous effects on human health, especially when they are found in everyday materials such as paint, adhesive removers, tobacco smoke, and stored fuels (Mølhave, ; World Health Organization, ; Fang et al., ).…”
mentioning
confidence: 99%