Characteristics and properties of hydoxyapatite derived by sol–gel and wet chemical precipitation methods

Ramesh, S.; Natasha, A.N.; Tan, C.Y.; Bang, L. T.; Niakan, A.; Purbolaksono, J.; Chandran, Hari; Ching, C.Y.; Teng, W.D.

doi:10.1016/j.ceramint.2015.04.105

Cited by 70 publications

(37 citation statements)

References 34 publications

(64 reference statements)

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“…One of the most promising approaches still remains the adjustment of technological parameters, that is, temperature, pH, stirring rate, etc., of the wet chemical precipitation method to inhibit growth of the crystals . Despite large number of researches dealing with synthesis of nanocrystalline HAp, there are only few reports about HAp precipitation below room temperature.…”

Section: Introductionmentioning

confidence: 99%

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Low‐temperature synthesis of nanocrystalline hydroxyapatite: Effect of Mg and Sr content

2017

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Nanocrystalline Mg-or Sr-containing hydroxyapatite powders were synthesized through low-temperature chemical precipitation. The most significant factor for reduction in particle sizes included adjusting the reaction temperature between 0°C and 50°C. Syntheses products were characterized using several analytical tools to determine purity and influence of added amount (up to 15 mol%) of Mg or Sr on the composition and structure. Qualitative analysis by Fourier transform infrared spectroscopy and low intensity, broad X-ray diffraction peaks indicated the presence of nanocrystalline and/or amorphous hydroxyapatite in all the products. Moreover, a significant decrease in the crystallinity was observed with increasing Mg (up to 2.8 AE 0.3 wt%) and Sr (up to 9.6 AE 1.0 wt%) concentration. N 2 adsorption and scanning electron microscopy characterizations confirmed the nanocrystalline nature of the synthesized products. The synthesized products had nanosized spherical-like particle morphology with the specific surface area ranging from 89 AE 7 to 150 AE 20 m 2 /g. K E Y W O R D Sbiomaterials, crystal structure, hydroxyapatite, nucleation, precipitation

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Section: Introductionmentioning

confidence: 99%

“…Despite large number of researches dealing with synthesis of nanocrystalline HAp, there are only few reports about HAp precipitation below room temperature. There have been some attempts to synthesize calcium phosphates (CaP) at 2°C, 5°C, 10°C, 15°C, and 20°C …”

Section: Introductionmentioning

confidence: 99%

Low‐temperature synthesis of nanocrystalline hydroxyapatite: Effect of Mg and Sr content

2017

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“…HA-coated GO shows a very similar shape to the needle-like shape than that of pure HA, which is almost needle-like with smaller size. Needle-like particles are capable of enhancing sinterability and fracture toughness, which are required in bone implantation (Ramesh et al 2015).…”

Section: Absorption Of Fibronectin (Fn)mentioning

confidence: 99%

“…Wet Wp method is the most convenient technique because it can produce a large quantity of HA powder and produce smaller crystallite size compared with the Sg method. In addition, impurity elements are not involved in this method, and the by-product is water (Ramesh et al 2015). The various morphologies of HA can be obtained by controlling the process conditions during the synthesis period P.…”

Section: Introductionmentioning

confidence: 99%

Adsorption of Extracellular Matrix Protein Fibronectin on the Surface of the Nanocomposite Particle of Graphene Oxide-Hydroxyapatite

Hashim¹,

Sawal²,

Rafie³

et al. 2018

JKUKM

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The study of biomaterials as implants have rapidly increased over recent decades to address the issues of tissue and bone disease. The combination of graphene oxide (GO) with hydroxyapatite (HA) is expected to promote the adsorption of protein fibronectin (FN). GO was produced by Hummer's method. Calcium hydroxide (Ca(OH) 2 at 0.1, 1.0 and 2.0 M) was used as a precursor of HA for the synthesis different GO compositions (0%, 0.1% and 1.0%) through wet chemical precipitation method. The molarity of Ca(OH) 2 and the composition of GO played an important role in the morphology, particle size, distribution of GO on HA surface and absorption of protein. GO and GO-HA composites were characterized using Fourier transform infrared spectroscopy, X-ray diffraction and field-emission scanning electron microscopy. Energy-dispersive X-ray spectroscopy was used to investigate protein adsorption. The average percentage yield of GO-HA composite production was highest (96.93%) at 2.0 M of Ca(OH) 2 . The optimum condition of GO-HA composite was 0.1 M Ca(OH) 2 and 0.1% GO composition, which resulted in needle-like shape with 48.38 nm width and 201.0 nm length, well conjugation, as well as the higher distribution of GO onto the HA surface. The elemental composition of carbon (C) of GO-HA was 44% and that of uncoated HA was 33%, which confirmed the adsorption of FN. Moreover, carbon element mapping proved that the absorption of FN towards GO-HA was successful. GO-HA nanocomposite can be a promising highly biocompatible material for medical implants. ABSTRAKKajian berkenaan biobahan sebagai implan telah berkembang dengan pesat sejak beberapa dekad kebelakangan ini bagi menangani isu-isu penyakit tisu dan tulang. Gabungan antara grafin oksida (GO) dan hidroksiapatit (HA) adalah dijangka dapat menggalakkan penjerapan protein fibronektin (FN). GO telah dihasilkan menerusi modifikasi daripada kaedah Hummer. Kemolaran kalsium hidroksida Ca(OH) 2 pada (0.1M, 1.0M dan 2.0M) digunakan sebagai larutan asas bagi HA untuk sintesis komposisi GO yang berbeza iaitu pada (0%, 0.1% dan 1.0%) melalui kaedah pemendakan kimia basah. Kemolaran Ca(OH) 2 dan komposisi GO adalah memainkan peranan penting dalam menentukan morfologi, saiz partikel, taburan GO terhadap permukaan HA dan penjerapan protein. GO dan komposit GO-HA dicirikan menggunakan Spektroskopi Inframerah Transformasi Fourier, Pembelauan Sinar-X, Mikroskop Electron Sekunder Bidang Emisi. Spektroskopi Serakan Tenaga Sinar-X pula digunakan untuk menganalisa penjerapan protein. Peratusan hasil tindak balas penghasilan komposit GO-HA adalah tertinggi (96.93%) pada molariti Ca(OH) 2 iaitu 2.0M. Kondisi optimum bagi komposit GO-HA adalah 0.1M Ca(OH) 2 dan 0.1% komposisi GO, yang mana menghasilkan GO-HA yang berbentuk seperti jarum dengan lebar 48.38 nm dan panjang saiz 201.0 nm, konjugasi yang baik dan bahkan menghasilkan taburan GO yang tinggi ke atas permukaan HA. Penjerapan FN dibuktikan oleh komposisi elemen karbon (C) bagi GO-HA iaitu 44% dan HA tanpa kehadiran GO adalah 33%. Tambahan pula, ...

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“…The bio-inertness of alumina has no harmful effect on cells and tissues [8,9]. Several methods were employed to synthesis HAp−Al 2 O 3 composites such as sol-gel [10], coprecipitation method [11], ball mill [12], under-water shock compaction [13], protein-foaming consolidation method [14] and microwave-assisted preparation [15]. Based on the literature study, no hydrothermal experimental procedure was reported on the preparation of HAp−Al 2 O 3 nanocomposites.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of hydroxyapatite/alumina ceramic nanocomposites for biomedical applications

Raj

Rajkumar²,

Sundaram³

et al. 2018

Bull Mater Sci

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In the present work, nanocrystalline hydroxyapatite/alumina (HAp−Al 2 O 3) composite was prepared under specially designed stir-type hydrothermal reactor. The composite was prepared at two different temperatures under autogenous pressure and analysed for crystallinity, size, shape, composition and thermomechanical stability. The electron microscopy study shows the formation of HAp−Al 2 O 3 composite nanorods with uniform distribution. The thermogravimetry analysis reveals better thermomechanical property with minimal weight loss at increased temperature. The effect of different concentrations of HAp−Al 2 O 3 composite powders against MG63 human osteosarcoma cell lines shows excellent compatibility (80%) at high concentration of 200 μg ml −1. These studies facilitate the formation of biocompatible HAp−Al 2 O 3 composite nanorods for biomedical applications.

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Characteristics and properties of hydoxyapatite derived by sol–gel and wet chemical precipitation methods

Cited by 70 publications

References 34 publications

Low‐temperature synthesis of nanocrystalline hydroxyapatite: Effect of Mg and Sr content

Low‐temperature synthesis of nanocrystalline hydroxyapatite: Effect of Mg and Sr content

Adsorption of Extracellular Matrix Protein Fibronectin on the Surface of the Nanocomposite Particle of Graphene Oxide-Hydroxyapatite

Synthesis and characterization of hydroxyapatite/alumina ceramic nanocomposites for biomedical applications

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