Low‐temperature synthesis of nanocrystalline hydroxyapatite: Effect of Mg and Sr content

Abstract

Nanocrystalline Mg-or Sr-containing hydroxyapatite powders were synthesized through low-temperature chemical precipitation. The most significant factor for reduction in particle sizes included adjusting the reaction temperature between 0°C and 50°C. Syntheses products were characterized using several analytical tools to determine purity and influence of added amount (up to 15 mol%) of Mg or Sr on the composition and structure. Qualitative analysis by Fourier transform infrared spectroscopy and low intensity, broad X-ray diffraction peaks indicated the presence of nanocrystalline and/or amorphous hydroxyapatite in all the products. Moreover, a significant decrease in the crystallinity was observed with increasing Mg (up to 2.8 AE 0.3 wt%) and Sr (up to 9.6 AE 1.0 wt%) concentration. N 2 adsorption and scanning electron microscopy characterizations confirmed the nanocrystalline nature of the synthesized products. The synthesized products had nanosized spherical-like particle morphology with the specific surface area ranging from 89 AE 7 to 150 AE 20 m 2 /g. K E Y W O R D Sbiomaterials, crystal structure, hydroxyapatite, nucleation, precipitation

Comparative study of surface properties of Mg-substituted hydroxyapatite bioceramic microspheres

“…However, sintering at temperature higher than 1173 K caused an increase of β-TCP content of the 3MgHAp products as demonstrated by the presence of additional reflections in XRD patterns. This confirmed a destabilizing effect of Mg on HAp phase at high temperatures de facto as reported in literature [6,7,26,27].…”

“…FT-IR spectra of the as-dried Mg-substituted HAp microspheres (not shown) presented the characteristic vibrational bands of typical partially carbonated and hydrated apatite, as described in Refs. [6,7]. Thermal treatment did not contribute to the change of a position of [PO 4 ] absorbance bands, while the absorbance bands characteristic to [HPO 4 ] and [CO 3 ] gradually disappeared.…”

“…Therefore, the most recent studies in the field of bone grafting materials, particularly HAp, have been focused on control of chemical composition in order to optimise bioresorbability and bioactivity, as well as to impart specific properties [5]. As such, a wide range of elements, including, Mg [6,7], Sr [7,8], Zn [8], Ag [9] etc. have been strategically incorporated intostructure of synthetic HAp.…”

Effect of anions on the structural, morphological and dielectric properties of hydrothermally synthesized hydroxyapatite nanoparticles

“…Therefore, alternative methods and simple techniques are employed to synthesize HA nanoparticles in industrial-scale with good quality, uniformity and perfect crystalline structure [11]. The various synthetic methods used to generate HA nanoparticles include microwave assisted, hydrothermal, sol-gel, microemulsion, freezing method, solvothermal, high-gravity precipitation and chemical precipitation methods [11][12][13][14][15][16][17]. However, in recent years, autoclave assisted hydrothermal method is also highly employed for the nanoparticle synthesis.…”

Role of strontium substitution in spray drying of hydroxyapatite: A comparative study on physical properties

“…However, the heat‐treated SD‐16SrHA presented both HA and β‐tricalcium phosphate (β‐TCP) peaks (as also detected in the SAED analyze). It is proposed that the increasing amount of the Sr substitution caused to decompose the HA to β‐TCP (Figure B) …”