Cerium oxide nanoparticles as a new neuroprotective agent to promote functional recovery in a rat model of sciatic nerve crush injury

Soluki, Milad; Mahmoudi, Fariba; Abdolmaleki, Arash; Asadi, Asadollah; Namini, Abbas Sabahi

doi:10.1080/02688697.2020.1864292

Cited by 21 publications

(11 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to the antioxidant properties of CeONPs, they are expected to help nerve regeneration after SCI. The effect of CeONPs has been examined for the recovery of nerve tissue in-vitro [16], in sciatic nerve crush injury in vivo [17], and in functional recovery after SCI [18]. Despite the fact that CeONPs can act as powerful antioxidants, and these are known to bene t SCI, so far there is no report on whether CeONP administration could help neuron regeneration and relieve neuropathic pain after SCI.…”

Section: Introductionmentioning

confidence: 99%

Injection of Cerium Oxide Nanoparticles To Treat Spinal Cord Injury In Rats

Behroozi

Rahimi

Hamblin

et al. 2021

Preprint

View full text Add to dashboard Cite

Introduction: The present study, investigated the local injection of cerium oxide nanoparticles (CeONPs) into Spinal cord injury (SCI) lesions in rats, and the effect on motor performance and neuropathic pain, together with biochemical markers.Methods: 36 adult male Wistar rats were divided into 4 groups: control group (healthy animals); sham group (laminectomy); SCI group (laminectomy+SCI induction); treatment group (laminectomy + SCI induction + intrathecal injection of 10 µL of CeONPs (1000 µg/mL) immediately after injury). SCI was induced by application of an aneurysm clip at the T12-T13 vertebral region. Immediately after SCI, CeONPs were injected into the treatment group with a Hamilton syringe and micropipet. H&E staining and measurement of the size of the cavity were performed after 6 weeks, and the BBB motor performance test and pain threshold test were performed weekly. GCSF expression, P44/42 MAPK (ERK1/ERK2), P-P44/42 MAPK (ERK1/ERK2), total Tau, total MAG, β-actin were evaluated after 6 weeks.Results: The BBB score and pain threshold improved in animals receiving CeONPs compared with SCI animals. The size of the cavity decreased in the treatment group. GCSF protein expression levels were similar in animals receiving CeONPs compared with the SCI group, but the expression of ERK1/ERK2 and phospho-ERK was lower compared with the SCI group. The expression levels of Tau and MAG were significantly increased in treated animals compared to the SCI group.Conclusion: The use of CeONPs in SCI could improve motor functional recovery, reduce pain and increase nerve cell regeneration.

show abstract

Section: Introductionmentioning

confidence: 99%

Injection of Cerium Oxide Nanoparticles To Treat Spinal Cord Injury In Rats

Behroozi

Rahimi

Hamblin

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…In order to improving the outcome of nerve regeneration injuries, many efforts have been undertaken. In this regards, previous studies indicated that pharmacological therapy is often recommended following peripheral nerve [26,27,29,30]. The potential neuroprotective effects of glibenclamide were assessed in this research GB as a new candidate for promoting nerve regeneration and functional improvement following sciatic nerve damage.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Glibenclamide promoted functional recovery following sciatic nerve injury in male Wistar rats

Ferdowsi

Abdolmaleki

Asadi

et al. 2022

Fundamemntal Clinical Pharma

Self Cite

View full text Add to dashboard Cite

The impact of peripheral nerve damage on a patient's quality of life is severe. The most frequent peripheral nerve crush damage is a sciatic nerve injury. Previous research has shown that glibenclamide (GB) has neuroprotective properties in a variety of oxidative stress‐related disorders, including Alzheimer and Parkinson. The goal of this study was to see how GB affected nerve regeneration and improved function of the sciatic nerve in a rat model following a crush injury. We evaluated motor function, sensory recovery, gene expression, and histomorphometry following damage at different time points. Additionally, we assessed atrophy in the gastrocnemius muscle using histology and mass ratio analyses. Our results suggest that 2, 4, 6, and 8 weeks following glibenclamide therapy, promotes the recovery of motor and sensory function in the injured site. Following glibenclamid injection, the mRNA levels of neurotrophic factors (NGF and BDNF) are raised. According to histomorphometry assessment, glibenclamide injection also increased the number of myelinated fibers while decreasing their thickness. These results showed that glibenclamide therapy by decreasing the proinflammatory and oxidant factors may enhance the nerve regeneration. It is clear that more research is needed to confirm these findings.

show abstract

“…Histomorphometric analysis of regenerated nerves was carried out eight weeks after surgery according to the previous method (10).…”

Section: Histomorphometric Analysismentioning

confidence: 99%

Neuroprotective Effects of Fe3O4 Nanoparticles Coated with Omega-3 as a Novel Drug for Recovery of Sciatic Nerve Injury in Rats

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background: Novel nanoparticle drug therapy could be an effective method to enhance peripheral nerve regeneration. Objectives: The current study aimed to determine the effect of Fe3O4 nanoparticles (NP) coated with omega-3 on sciatic nerve regeneration in Wistar rats. Methods: The rats' left sciatic nerve was crushed with a non-serrated clamp. Animals in experimental groups were given Fe3O4@ω3 NPs (10 or 30 mg/kg/d) for one week. The recovery of functions was then assessed over eight weeks using a walking track analysis and a hot plate test. In addition, histomorphometry was used to assess the histomorphometric factors. Results: Results showed that Fe3O4@ω3 NPs may have enhanced sciatic nerve regeneration and improved sensorimotor rehabilitation in comparison to the negative controls. These therapeutic effects were significantly greater in Fe3O4@ω3 NPs at a dose of 30 mg/kg. Furthermore, Fe3O4@ω3 NPs treatment, compared to negative controls, significantly reduced gastrocnemius muscle atrophy and improved histomorphometric parameters. Conclusions: It was determined that Fe3O4@ω3 NPs had great potential for nerve regeneration due to the ease of their manufacturing and their desired efficacy.

show abstract

Cerium oxide nanoparticles as a new neuroprotective agent to promote functional recovery in a rat model of sciatic nerve crush injury

Cited by 21 publications

References 26 publications

Injection of Cerium Oxide Nanoparticles To Treat Spinal Cord Injury In Rats

Injection of Cerium Oxide Nanoparticles To Treat Spinal Cord Injury In Rats

Glibenclamide promoted functional recovery following sciatic nerve injury in male Wistar rats

Neuroprotective Effects of Fe3O4 Nanoparticles Coated with Omega-3 as a Novel Drug for Recovery of Sciatic Nerve Injury in Rats

Contact Info

Product

Resources

About