Glibenclamide promoted functional recovery following sciatic nerve injury in male Wistar rats

Abstract

The impact of peripheral nerve damage on a patient's quality of life is severe. The most frequent peripheral nerve crush damage is a sciatic nerve injury. Previous research has shown that glibenclamide (GB) has neuroprotective properties in a variety of oxidative stress‐related disorders, including Alzheimer and Parkinson. The goal of this study was to see how GB affected nerve regeneration and improved function of the sciatic nerve in a rat model following a crush injury. We evaluated motor function, sensory recovery, gene expression, and histomorphometry following damage at different time points. Additionally, we assessed atrophy in the gastrocnemius muscle using histology and mass ratio analyses. Our results suggest that 2, 4, 6, and 8 weeks following glibenclamide therapy, promotes the recovery of motor and sensory function in the injured site. Following glibenclamid injection, the mRNA levels of neurotrophic factors (NGF and BDNF) are raised. According to histomorphometry assessment, glibenclamide injection also increased the number of myelinated fibers while decreasing their thickness. These results showed that glibenclamide therapy by decreasing the proinflammatory and oxidant factors may enhance the nerve regeneration. It is clear that more research is needed to confirm these findings.

The impact of ATP-sensitive potassium channel modulation on mitochondria in a Parkinson’s disease model using SH-SY5Y cells depends on their differentiation state

“…Prior investigations have documented the beneficial effects of glibenclamide in various neurodegeneration models, particularly in terms of its ultimate effects on neurons. Several studies have reported an anti-inflammatory effect of glibenclamide in connection with Parkinson’s disease (Abdelkader et al 2020 ; Qiu et al 2021 ; Ferdowsi et al 2022 ). All documented anti-inflammatory effects of glibenclamide are rooted in animal models, highlighting its ultimate impact on neurons.…”

Effect and mechanism of Tetramethylpyrazine in repair of sciatic nerve injury in rats

“…Sciatic nerve injury (SNI) has the characteristics of high disability rate and di cult recovery of nerve function [1], and secondary lesions will spread to the surrounding normal tissues, resulting in chronic loss of function [2]. The etiology of secondary damage in SNI is not yet clear, but microcirculation disturbance is considered to be one of the important reasons for secondary damage [3][4][5]. Tetramethylpyrazine (TMP) can inhibit platelet aggregation, prevent thrombosis, dilate arterioles, enhance myocardial contraction, inhibit apoptosis, and reduce in ammatory reactions [6][7][8][9][10].…”