Background: Novel nanoparticle drug therapy could be an effective method to enhance peripheral nerve regeneration. Objectives: The current study aimed to determine the effect of Fe3O4 nanoparticles (NP) coated with omega-3 on sciatic nerve regeneration in Wistar rats. Methods: The rats' left sciatic nerve was crushed with a non-serrated clamp. Animals in experimental groups were given Fe3O4@ω3 NPs (10 or 30 mg/kg/d) for one week. The recovery of functions was then assessed over eight weeks using a walking track analysis and a hot plate test. In addition, histomorphometry was used to assess the histomorphometric factors. Results: Results showed that Fe3O4@ω3 NPs may have enhanced sciatic nerve regeneration and improved sensorimotor rehabilitation in comparison to the negative controls. These therapeutic effects were significantly greater in Fe3O4@ω3 NPs at a dose of 30 mg/kg. Furthermore, Fe3O4@ω3 NPs treatment, compared to negative controls, significantly reduced gastrocnemius muscle atrophy and improved histomorphometric parameters. Conclusions: It was determined that Fe3O4@ω3 NPs had great potential for nerve regeneration due to the ease of their manufacturing and their desired efficacy.
Background and Objectives: Due to its unique properties, iron oxide nanoparticles have many applications in medicine. The aim of this study was to prepare omega-3 coated iron oxide nanoparticles and investigate their effect on liver and kidney, and spleen function in rats.
Materials and Methods:In this experimental study, 30 Wistar rats were randomly divided into three groups including control group (receiving physiology serum as drug solvent), experimental groups 1 and 2 treated with omega-3 coated iron oxide nanoparticles with doses of 10 and 30 mg/kg, respectively. After one week of drug treatment, blood sampling and tissue sampling of liver, kidney, and spleen were performed. One-way analysis of variance, Tukey's post hoc, Levene, and non-parametric Kolmogorov-Smirnov tests were used for data analysis.
Results:Injection of nanoparticles at a dose of 10 mg/kg did not show a significant change in blood urea and AST (Aspartate Transaminase) factors compared to the control group (p=0.042). However, at a dose of 30 mg/kg, creatinine and ALT (Alanine Transaminase) blood factors increased significantly compared to the control group (p =0.038). Histopathological examination of liver, kidney, and spleen tissue samples of the treated groups did not show any tissue disorders compared to the control group.
Conclusion:The results showed that omega-3 coated iron oxide nanoparticles at low doses had no toxic effects on the studied tissues and did not disrupt blood factors. Therefore, it can be further evaluated as an adjunct in the treatment of cancer cells as well as drug carriers.
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