Catalytic mechanism and application of nanozymes

Li, Zhuoxuan; Feng, Kaizheng; Zhang, Wei; Ma, Ming; Gu, Ning; Yu, Zhang

doi:10.1360/n972018-00426

Cited by 14 publications

(5 citation statements)

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“…Compared with natural enzymes, the various advantages of nanozymes potentiate a wider range of applications. As an essential part of nanoenzyme materials, noble metal-based nanozymes have attracted much attention due to their high biocompatibility, simple synthesis, and easy modification ( 21 ). They have been studied and applied in multiple fields for bioactive molecular detection, disease diagnosis, treatment, antibacterial, etc ( 22 ).…”

Section: Noble Metal Biomimetic Nanozymesmentioning

confidence: 99%

Latest advances in biomimetic nanomaterials for diagnosis and treatment of cardiovascular disease

Gong

Liu

Shi

et al. 2023

Front. Cardiovasc. Med.

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Cardiovascular disease remains one of the leading causes of death in China, with increasingly serious negative effects on people and society. Despite significant advances in preventing and treating cardiovascular diseases, such as atrial fibrillation/flutter and heart failure over the last few years, much more remains to be done. Therefore, developing innovative methods for identifying and managing cardiovascular disorders is critical. Nanomaterials provide multiple benefits in biomedicine, primarily better catalytic activity, drug loading, targeting, and imaging. Biomimetic materials and nanoparticles are specially combined to synthesize biomimetic nanoparticles that successfully reduce the nanoparticles’ toxicity and immunogenicity while enhancing histocompatibility. Additionally, the biological targeting capability of nanoparticles facilitates the diagnosis and therapy of cardiovascular disease. Nowadays, nanomedicine still faces numerous challenges, which necessitates creating nanoparticles that are highly selective, toxic-free, and better clinically applicable. This study reviews the scientific accomplishments in this field over the past few years covering the classification, applications, and prospects of noble metal biomimetic nanozymes and biomimetic nanocarriers.

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Section: Noble Metal Biomimetic Nanozymesmentioning

confidence: 99%

Latest advances in biomimetic nanomaterials for diagnosis and treatment of cardiovascular disease

Gong

Liu

Shi

et al. 2023

Front. Cardiovasc. Med.

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“…Consequently, it is of significant importance to categorize the underlying principles of nanozymes within the context of pathogen detection. The catalytic activity of a nanozyme relies on the surface electron transfer process [48]. Researchers employed electron spin resonance (ESR) [49], density functional theory (DFT) [50], X-ray photoelectron spectroscopy (XPS) [51], and ultraviolet-visible spectrophotometry (UV) [52] to investigate the catalytic reaction mechanism of a nanozyme while employing an enzyme steady-state kinetic analysis to examine its catalytic activity.…”

Section: Nanozyme-mediated Detection Mechanismsmentioning

confidence: 99%

Recent Advances in Nanozyme-Mediated Strategies for Pathogen Detection and Control

Ma,

Huang,

Cheng

2023

IJMS

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Pathogen detection and control have long presented formidable challenges in the domains of medicine and public health. This review paper underscores the potential of nanozymes as emerging bio-mimetic enzymes that hold promise in effectively tackling these challenges. The key features and advantages of nanozymes are introduced, encompassing their comparable catalytic activity to natural enzymes, enhanced stability and reliability, cost effectiveness, and straightforward preparation methods. Subsequently, the paper delves into the detailed utilization of nanozymes for pathogen detection. This includes their application as biosensors, facilitating rapid and sensitive identification of diverse pathogens, including bacteria, viruses, and plasmodium. Furthermore, the paper explores strategies employing nanozymes for pathogen control, such as the regulation of reactive oxygen species (ROS), HOBr/Cl regulation, and clearance of extracellular DNA to impede pathogen growth and transmission. The review underscores the vast potential of nanozymes in pathogen detection and control through numerous specific examples and case studies. The authors highlight the efficiency, rapidity, and specificity of pathogen detection achieved with nanozymes, employing various strategies. They also demonstrate the feasibility of nanozymes in hindering pathogen growth and transmission. These innovative approaches employing nanozymes are projected to provide novel options for early disease diagnoses, treatment, and prevention. Through a comprehensive discourse on the characteristics and advantages of nanozymes, as well as diverse application approaches, this paper serves as a crucial reference and guide for further research and development in nanozyme technology. The expectation is that such advancements will significantly contribute to enhancing disease control measures and improving public health outcomes.

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“…[10][11][12] Nevertheless, their intrinsic shortcomings including high cost, poor stability, and limited possibility to scale up for manufacturing greatly hamper their further usage as antibacterial agents. 5,[12][13][14] Thus, the efficient antibacterial agents aiming for clinical translations need to be explored.…”

Section: Introductionmentioning

confidence: 99%

“…5,[16][17][18][19][20] With the recent advances of nanotechnology, nanozymes have revolutionized previous fundamental understandings in the field of biology, chemistry, and medicine. [18][19][20][21][22][23] At present, several nanozymes, including carbon-based nanomaterials, 13,18,24,25 noble metal nanomaterials, 26 transition metal-based compounds nanomaterials, 27 metal organic framework (MOF)-related nanomaterials, 5,28,29 and single-atom nanozymes, 30,31 have been extensively studied in biomedicine for diagnostics by catalytic generation of ROS, including O 2 •− , H 2 O 2 , 1 O 2 , and hydroxyl radical (•OH). 5 For instance, noble metal nanomaterials can mimic oxidase (OXD) to catalyze some substrates (e.g., ascorbic acid) and oxygen for generating H 2 O 2…”

Section: Introductionmentioning

confidence: 99%

“…In our living body, natural enzymes can catalyze various substrates to produce a series of reactive oxygen species (ROS) for fighting bacterial invasion 10–12 . Nevertheless, their intrinsic shortcomings including high cost, poor stability, and limited possibility to scale up for manufacturing greatly hamper their further usage as antibacterial agents 5,12–14 . Thus, the efficient antibacterial agents aiming for clinical translations need to be explored.…”

Section: Introductionmentioning

confidence: 99%

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Emerging antibacterial nanozymes for wound healing

et al. 2023

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Wound infections continuously impose a huge economic and social burden on public healthcare. Despite the effective treatment of bacteria‐infected wounds after using traditional antibiotics, the misuse of antibiotics usually causes the spread of bacterial resistance and decreases therapeutic outcomes. Therefore, the development of efficient antibacterial agents is urgently needed. Nanozymes, as a new generation of artificial enzymes, combine the intrinsic abilities of nanomaterials and natural enzymes. Recently, nanozymes has been widely developed to kill bacteria and treat wound infections by catalyzing the generation of various reactive oxygen species. Thus, this new concept of “antibacterial nanozymes” will promote the further advances of connecting nanozymes and bacterial elimination. To highlight these achievements, we summarize different types of antibacterial nanozymes for wound healing. It is believed that such a promising therapeutic strategy of developing antibacterial nanozymes will make a great contribution in the field of skin regeneration. We expect that antibacterial nanozymes will play the significant roles in both basic research and clinical applications.

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Catalytic mechanism and application of nanozymes

Cited by 14 publications

References 0 publications

Latest advances in biomimetic nanomaterials for diagnosis and treatment of cardiovascular disease

Latest advances in biomimetic nanomaterials for diagnosis and treatment of cardiovascular disease

Recent Advances in Nanozyme-Mediated Strategies for Pathogen Detection and Control

Emerging antibacterial nanozymes for wound healing

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