Carcinosarcoma and Sarcomatoid Carcinoma of the Bladder: Clinicopathological Study of 41 Cases

López-Beltrán, Antonio; Pacelli, Anna; Rothenberg, Harold J.; Wollan, Peter C.; Zincke, Horst; Blute, Michael L.; Bostwick, David G.

doi:10.1097/00005392-199805000-00023

Cited by 246 publications

(287 citation statements)

References 21 publications

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“…2 Although there has been no unified opinion or agreement on histogenesis and nomenclature, recently in such cases, the terms carcinosarcoma or sarcomatoid carcinoma have been used. 1 Both of these can be clearly defined. Carcinosarcoma is an admixture of an epithelial malignant component and a malignant soft tissue component in a tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Although it is occasionally difficult to make a diagnosis, immunohistochemical study is of particular value in these tumors. [1][2][3][4][5] In our immunohistochemical study, in case 1, the sarcomatoid component consisted of spindle cells and was focally CK-and EMA-positive, which suggested this tumor was derived from an epithelial origin. Differentiation toward skeletal muscle or chondro-osseous tissue in the spindle cell component was not found.…”

Section: Discussionmentioning

confidence: 99%

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Sarcomatoid carcinoma and carcinosarcoma of the urinary bladder

Ogishima¹,

Kawachi²,

Saito

et al. 2002

Int J of Urology

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Two cases, sarcomatoid carcinoma and carcinosarcoma, of the urinary bladder are reported. A 68-year-old man with sarcomatoid carcinoma underwent total cystectomy and was alive and had had no recurrence after 21 months. A 78-year-old woman with carcinosarcoma underwent total cystectomy, but she died from increasing multiple lung metastases 4 months after surgery. The histopathological characteristics of both neoplasms are reported and discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sarcomatoid carcinoma and carcinosarcoma of the urinary bladder

Ogishima¹,

Kawachi²,

Saito

et al. 2002

Int J of Urology

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“…Sarkomatoid diferensiyasyon gösteren mesane tümörlerinde tanıdan sonraki bir yıl içinde hastaların %66'sında metastaz geliştiği bildirilmekte-dir. Lopez Beltran'ın çalışmasındaki 26 hastanın ortalama 10 aylık dönemde kaybedildiği görülmektedir (10). Olgumuz operasyon sonrası 2 yıl geçmiş olup bu süre içerisinde nüks olmaksızın yaşa-mını devem ettirmektedir.…”

Section: Discussionunclassified

Sarcomatoid and Lymphoepithelioma Like Differentiated Carcinoma of the Urinary Bladder: Partial Cystectomy a Case Report

Özkan¹,

Balci²,

Hazar³

et al. 2014

JAREM

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ÖZETMesanede en sık rastlanan tümörler ürotelyal karsinomlar olmakla birlikte mesane kanserlerinin %10-20' sinde farklı diferansiyasyon gösteren tümörlerde bulunabilir. Bunlardan biride sarkomatoid ve lenfoepitelyoma benzeri diferansiyasyon gösteren ürotelyal karsinomdur. Daha çok erkeklerde ve ileri yaşta görülür. Tanı anında genelde ileri evredirler. Agresif neoplaziler olup sürvileri kötüdür. Literatürde çeşitli tedavi modaliteleri belirlenmiş olup kesin bir standart yoktur. Bu yazıda ender rastlanan sarkomatoid ve lenfoepitelyoma benzeri diferansiyasyon gösteren ürotelyal mesane karsinomu vakasına uyguladığımız parsiyel sistektominin sonucu literatür eşliğinde tartışılmıştır. (JAREM 2014; 1: 35-7) Anahtar Sözcükler: Mesane, sarkomatoid, ürotelyal karsinom, parsiyel sistektomi ABSTRACT Urothelial carcinomas are the most common tumor types in urinary bladder; however, there may exist different differentiations in 10-20% of bladder cancer, one of which is urothelial carcinoma that has sarcomatoid-and/or lymphoepithelioma-like differentiation. It is usually seen in males in older age and diagnosed during later stages. They are aggressive malignancies and have low survival. Although there are various treatment models determined in the literature, no certain standard is identified. In this study, we report a case of sarcomatoid-and lymphoepithelioma-like differentiated urothelial carcinoma of the urinary bladder that was treated by partial cystectomy and its results in light of the literature. (JAREM 2014; 1: 35-7) Key Words: Urinary bladder, sarcomatoid, urothelial carcinoma, partial cystectomy GİRİŞ Ürolojik kanserler içinde prostat kanserinden sonra ikinci sırada yer alan mesane tümörleri, erkeklerde görülen kanserler içinde dördüncü, kadınlarda ise sekizinci sırada yer almaktadır (1). Mesanede en sık %90-95 oranla ürotelyal hücreli kanser görülür, tanı sırasında yaklaşık %10-20'sinde farklı diferansiyasyon gösteren tü-mörlerde görülebilir (2). Sarkomatoid diferansiyasyon Torenbeek ve ark. (3) 4191 mesane kanserli hastayı inceledikleri çalışmasında %0.31 olarak bildirilmektedir (3). Erkek: Kadın oranı 4:1 olup pik insidans 7. dekattadır (4).Biz, oldukça kötü prognoza sahip sarkomatoid ve lenfoepitelyoma benzeri diferansiyasyon gösteren ürotelyal karsinomun klinik, seyir, teşhis ve tedavi aşamalarıyla farklı bir vaka sunmayı amaç-ladık. OLGU SUNUMUElli altı yaşında erkek hasta pıhtılı makroskopik hematüri şikayet-leri ile kliniğimize başvurdu. Fizik muayenesi, serum biyokimyası ve kan sayımı normaldi. Üriner sistem ultrasonografide (USG) mesane posterior duvarda 50x45x35 mm boyutlarında kitle lezyon tespit edildi ve üst üriner sisteme ait patoloji izlenmedi (Resim 1).Hastaya transüretral rezeksiyon (TUR) planlandı. Sistoskopi önce-si yapılan bimanuel muayenede ele gelen kitle ve fiksasyon yoktu. Mesane arka duvar kubbe bileşkesinde yaklaşık 5 cm çapında papillo-solid tümoral odak izlendi ve rezeksiyon yapıldı (TUR-MT), mesaneden multipl ve prostatik üretradan örnekleme yapıldı. Cerrahi şifa ile eksterne ed...

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“…Immunohistochemically, epithelial elements react with cytokeratin, and stromal elements react with vimentin or specific markers of mesenchymal differentiation. Carcinoma in situ is present in 30% of cases and sometimes the epithelial component is composed only of carcinoma in situ (Lopez-Beltran et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

“…In the series reported by Lopez-Beltran et al only 1 of the 26 patients with sarcomatoid carcinoma was stage pT2; the others (96%) were stage pT3/4. Among the 21 patients with a sufficient length of follow-up, 17 died from the disease within a mean 9.8 months (Lopez-Beltran et al, 1998). Doghri et al (2012) reported a 75 year-old case diagnosed sarcomatoid carcinomas of the urinary bladder with no evidence of disease 12 months after transurethral resection under observation who diagnosed at an early stage.…”

Section: Discussionmentioning

confidence: 99%

Early Detection and Gemcitabine/Cisplatin Combination Positively Effect Survival in Sarcomatoid Carcinoma of the Urinary Bladder

Başeskioğlu¹,

Duman²,

Kara³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Carcinosarcoma and Sarcomatoid Carcinoma of the Bladder: Clinicopathological Study of 41 Cases

Abstract: Carcinosarcoma and sarcomatoid carcinoma of the bladder are highly aggressive malignancies with a similar outcome regardless of histological findings and treatment. Pathological stage is the best predictor of survival.

Cited by 246 publications

References 21 publications

Sarcomatoid carcinoma and carcinosarcoma of the urinary bladder

Sarcomatoid carcinoma and carcinosarcoma of the urinary bladder

Sarcomatoid and Lymphoepithelioma Like Differentiated Carcinoma of the Urinary Bladder: Partial Cystectomy a Case Report

Early Detection and Gemcitabine/Cisplatin Combination Positively Effect Survival in Sarcomatoid Carcinoma of the Urinary Bladder

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