Sarcomatoid carcinoma and carcinosarcoma of the urinary bladder

Ogishima, Tatsuya; Kawachi, Yoshio; Saito, Akira; Suzuki, Fujihiko; Ishi, Kazuhisa; Tanaka, Toru

doi:10.1046/j.1442-2042.2002.00472.x

Cited by 19 publications

(15 citation statements)

References 4 publications

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“…Polipoid, ülsere ve ilk tanıda muskuler tabakayıda invaze edecek şekilde ileri evrede olurlar (8), olgumuz soliter, 5 cm çapında, solid ve arka duvar kubbe bileşiminde yerleşimliydi. Tümörün agresif natürü, lokal rekürrense eğilimi nedeniyle sıklıkla cerrahi sonrası lokal rekürrens görülmesine rağmen radikal sistektomi ile adjuvan radyoterapi ve/veya kemoterapi kombinasyonu rehberlere net olarak gimemekle beraber önerilmektedir (9). Mesane sarkomatoid tümörü ortalama 17,2 ay gibi düşük sürviye sahiptir.…”

Section: Discussionunclassified

Sarcomatoid and Lymphoepithelioma Like Differentiated Carcinoma of the Urinary Bladder: Partial Cystectomy a Case Report

Özkan¹,

Balci²,

Hazar³

et al. 2014

JAREM

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ÖZETMesanede en sık rastlanan tümörler ürotelyal karsinomlar olmakla birlikte mesane kanserlerinin %10-20' sinde farklı diferansiyasyon gösteren tümörlerde bulunabilir. Bunlardan biride sarkomatoid ve lenfoepitelyoma benzeri diferansiyasyon gösteren ürotelyal karsinomdur. Daha çok erkeklerde ve ileri yaşta görülür. Tanı anında genelde ileri evredirler. Agresif neoplaziler olup sürvileri kötüdür. Literatürde çeşitli tedavi modaliteleri belirlenmiş olup kesin bir standart yoktur. Bu yazıda ender rastlanan sarkomatoid ve lenfoepitelyoma benzeri diferansiyasyon gösteren ürotelyal mesane karsinomu vakasına uyguladığımız parsiyel sistektominin sonucu literatür eşliğinde tartışılmıştır. (JAREM 2014; 1: 35-7) Anahtar Sözcükler: Mesane, sarkomatoid, ürotelyal karsinom, parsiyel sistektomi ABSTRACT Urothelial carcinomas are the most common tumor types in urinary bladder; however, there may exist different differentiations in 10-20% of bladder cancer, one of which is urothelial carcinoma that has sarcomatoid-and/or lymphoepithelioma-like differentiation. It is usually seen in males in older age and diagnosed during later stages. They are aggressive malignancies and have low survival. Although there are various treatment models determined in the literature, no certain standard is identified. In this study, we report a case of sarcomatoid-and lymphoepithelioma-like differentiated urothelial carcinoma of the urinary bladder that was treated by partial cystectomy and its results in light of the literature. (JAREM 2014; 1: 35-7) Key Words: Urinary bladder, sarcomatoid, urothelial carcinoma, partial cystectomy GİRİŞ Ürolojik kanserler içinde prostat kanserinden sonra ikinci sırada yer alan mesane tümörleri, erkeklerde görülen kanserler içinde dördüncü, kadınlarda ise sekizinci sırada yer almaktadır (1). Mesanede en sık %90-95 oranla ürotelyal hücreli kanser görülür, tanı sırasında yaklaşık %10-20'sinde farklı diferansiyasyon gösteren tü-mörlerde görülebilir (2). Sarkomatoid diferansiyasyon Torenbeek ve ark. (3) 4191 mesane kanserli hastayı inceledikleri çalışmasında %0.31 olarak bildirilmektedir (3). Erkek: Kadın oranı 4:1 olup pik insidans 7. dekattadır (4).Biz, oldukça kötü prognoza sahip sarkomatoid ve lenfoepitelyoma benzeri diferansiyasyon gösteren ürotelyal karsinomun klinik, seyir, teşhis ve tedavi aşamalarıyla farklı bir vaka sunmayı amaç-ladık. OLGU SUNUMUElli altı yaşında erkek hasta pıhtılı makroskopik hematüri şikayet-leri ile kliniğimize başvurdu. Fizik muayenesi, serum biyokimyası ve kan sayımı normaldi. Üriner sistem ultrasonografide (USG) mesane posterior duvarda 50x45x35 mm boyutlarında kitle lezyon tespit edildi ve üst üriner sisteme ait patoloji izlenmedi (Resim 1).Hastaya transüretral rezeksiyon (TUR) planlandı. Sistoskopi önce-si yapılan bimanuel muayenede ele gelen kitle ve fiksasyon yoktu. Mesane arka duvar kubbe bileşkesinde yaklaşık 5 cm çapında papillo-solid tümoral odak izlendi ve rezeksiyon yapıldı (TUR-MT), mesaneden multipl ve prostatik üretradan örnekleme yapıldı. Cerrahi şifa ile eksterne ed...

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Section: Discussionunclassified

Sarcomatoid and Lymphoepithelioma Like Differentiated Carcinoma of the Urinary Bladder: Partial Cystectomy a Case Report

Özkan¹,

Balci²,

Hazar³

et al. 2014

JAREM

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“…Diagnosis of carcinosarcoma of the bladder is usually made using conventional hematoxylin and eosin stained sections, especially when an easily identifiable carcinoma component is present in addition to the sarcomatous component. Although it is occasionally difficult to make a diagnosis, immunohistochemical analysis is of particular value in these tumors [6][7][8][9] . The carcinomatous component is epithelial marker-positive, while the sarcomatous component is negative, and it shows sarcomatous differentiation such as osteosarcoma, chondrosarcoma and rhabdomyosarcoma.…”

Section: Discussionmentioning

confidence: 99%

“…Hensley et al 15) reported that a 53% response rate was obtained with a combination therapy of gemcitabine, docetaxel and irradiation in unresectable leiomyosarcoma patients. Neoadjuvant chemotherapy was also a possible therapy, but we considered the possibility of tumor rapid growth and that the prognosis has been reported to be better in some reports [5][6][7][8]10) . Therefore, we performed radical cystectomy in a localized phase and achieved complete resection.…”

Section: Discussionmentioning

confidence: 99%

“…Cystectomy or transurethral resection of the bladder tumor (TUR-Bt) is the preferred treatment, often followed by radiation therapy, but the prognosis is very poor 1-7) . To our knowledge, almost 80 cases have been reported in Japan, usually as case reports or small series 6,7) . In almost all cases, the chief complaint was gross hematuria.…”

Section: Introductionmentioning

confidence: 99%

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Carcinosarcoma of the Urinary Bladder with Rapid Growth: A Case Report

et al. 2009

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Carcinosarcoma of the bladder is a rare malignancy characterized by an intimate admixture of malignant epithelial elements (carcinoma) and malignant soft tissue elements (sarcoma). Patients with carcinosarcoma usually present with high-stage malignancy. Cystectomy or transurethral resection of the bladder tumor (TUR-Bt) is the preferred treatment, often followed by radiation therapy, but the prognosis is very poor 1-7) . To our knowledge, almost 80 cases have been reported in Japan, usually as case reports or small series 6,7) . In almost all cases, the chief complaint was gross hematuria. We herein report a case of carcinosarcoma of the urinary bladder in a patient whose chief complaint was abdominal pain. His pain worsened, and the occurrence of hydronephrosis indicated that extremely rapid tumor growth may have occurred. No evidence of recurrence was noted 30 months after the performance of cystectomy.

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“…This type of tumor can occur in patients with a history of radiotherapy or chemotherapy. [7,8] Meyer (1920) classified carcinosarcomas into three histogenetic groups: 1) collision tumors in which carcinoma and sarcoma arise simultaneously in proximity and subsequently invade each other, 2) combination tumors in which both tumors derive from pluripotent cells, and 3) composition tumors in which the components arise from the same tissue. [9] Willis restricted the term carcinosarcoma by excluding collision tumors.…”

Section: Discussionmentioning

confidence: 99%

Giant vesical diverticulum, unilateral renal agenesis and mental retardation: an unusual association

Hacıhamdioğlu¹,

Kïbar²,

Gül³

et al. 2012

Turkish Journal of Urology

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Carcinosarcoma of the urinary bladder is a rare neoplasm that is composed of malignant epithelial and mesenchymal components. Fewer than 80 cases have been reported worldwide, usually as case reports or a small series. A series of 221 cases using the Surveillance, Epidemiology and End Results (SEER) Program database has been reported recently. We present one case of carcinosarcoma that was managed by neoadjuvant chemotherapy and that achieved a complete pathological response. A 57-year-old male patient presented with a 2-month history of hematuria. Ultrasonography revealed a 4 cm mass in the bladder dome. A transurethral resection of the bladder tumor (TURBT) revealed a carcinosarcoma. The patient underwent subsequent neoadjuvant chemotherapy and radiotherapy. The pathology specimen examination revealed no residual tumor. The patient had no evidence of recurrence after 20 months. This patient is the second reported case of carcinosarcoma of the urinary bladder that achieved a complete pathological response after neoadjuvant chemotherapy.

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Sarcomatoid carcinoma and carcinosarcoma of the urinary bladder

Cited by 19 publications

References 4 publications

Sarcomatoid and Lymphoepithelioma Like Differentiated Carcinoma of the Urinary Bladder: Partial Cystectomy a Case Report

Sarcomatoid and Lymphoepithelioma Like Differentiated Carcinoma of the Urinary Bladder: Partial Cystectomy a Case Report

Carcinosarcoma of the Urinary Bladder with Rapid Growth: A Case Report

Giant vesical diverticulum, unilateral renal agenesis and mental retardation: an unusual association

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