Early Detection and Gemcitabine/Cisplatin Combination Positively Effect Survival in Sarcomatoid Carcinoma of the Urinary Bladder

Başeskioğlu, Barbaros; Duman, Berna Bozkurt; Kara, İsmail Oğuz; Can, Cavit; Açıkalın, Mustafa Fuat

doi:10.7314/apjcp.2012.13.11.5729

Cited by 9 publications

(5 citation statements)

References 15 publications

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“…As to the etiology of carcinosarcoma of the urinary bladder, no definite risk factors have been identified to date; however, some investigators have suggested that it is associated with cigarette smoking like urothelial carcinoma [ 13 ]. Additionally, previous treatment with cyclophosphamide for previous conventional urothelial carcinoma in some patients and radiotherapy for previous endometrial carcinoma in a patient has been reported to result in sarcomatoid transformation [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, various combinations of neoadjuvant or adjuvant chemotherapy and/or radiotherapy after radical surgery have been advocated. Başeskioğlu et al [ 13 ] retrospectively studied the efficacy of perioperative treatment with GC (cisplatin/gemcitabine) regimen in seven patients with sarcomatoid carcinoma of the urinary bladder, and this resulted in all patients dying within 48 months after surgery. The outcomes of even multimodal treatments are unsatisfactory.…”

Section: Discussionmentioning

confidence: 99%

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A Case of Early Stage Bladder Carcinosarcoma in Late Recurrence of Urothelial Carcinoma after Transurethral Resection

Hirano¹,

Yoshida²,

Funakoshi

et al. 2018

Case Reports in Urology

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Carcinosarcomas of the urinary bladder are rare biphasic neoplasms, consisting of both malignant epithelial and malignant mesenchymal components, and the prognosis of this tumor is unfavorable in most patients with even possibility of resection of disease. A 77-year-old male with a history of transurethral resection (TUR) of urothelial carcinoma (UC) of the bladder and adjuvant intravesical chemotherapy with pirarubicin 10 years ago revisited our department with a gross hematuria. Cystoscopy demonstrated an approximately 2.5 cm nonpapillary tumor on the right wall of the bladder. Pelvic MRI showed the tumor without extending the base of the bladder wall. The tumor could be completely removed with TUR. The malignant epithelial elements consisted of high-grade UC and the majority of mesenchymal components were fibrosarcomatous differentiation based on immunohistochemical studies. The tumor could be pathologically also suspected to be an early stage on TUR specimens. Although he has received no additional intervention due to the occurrence of myocardial infarction at three weeks after the TUR, he has been alive with no evidence of recurrence of the disease 27 months after the TUR. Some early stages of bladder carcinosarcoma might have a favorable prognosis without aggressive treatments.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A Case of Early Stage Bladder Carcinosarcoma in Late Recurrence of Urothelial Carcinoma after Transurethral Resection

Hirano¹,

Yoshida²,

Funakoshi

et al. 2018

Case Reports in Urology

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“…8 Total cystectomy, often followed by radiation therapy and/or chemotherapy, seems to be the preferred treatment. 10 The effectiveness of these treatments is not known because of the varying results of each case. The factors predictive of long-term survival at the time of presentation are negative surgical margins and the absence of metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

Sarcomatoid squamous cell carcinoma of urinary bladder

Sekhar¹,

Ramana²,

Shamili³

et al. 2020

IJPO

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Among the urinary bladder malignancies, infiltrating urothelial carcinoma is the most common while sarcomatoid variant is a rare malignancy. As the literature shows only few published case reports, We present a case of polypoidal mass of urinary bladder which was excised by TURBT (Transurethral Resection of Bladder Tumor) procedure and histopathologically diagnosed as sarcomatoid squamous cell carcinoma.

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“…Recently has been suggested that early diagnosis and gemcitabine/cisplatin can positively affect survival. Multiinstitutional clinical trials are needed to establish protocols for the treatment of sarcomatoid carcinoma of the urinary bladder [1,[3][4][5][6][7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

Sarcomatoid Carcinoma of the Urinary Bladder: A Case Report and Review of the Literature

Sánchez

2014

J Med Cases

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Early Detection and Gemcitabine/Cisplatin Combination Positively Effect Survival in Sarcomatoid Carcinoma of the Urinary Bladder

Cited by 9 publications

References 15 publications

A Case of Early Stage Bladder Carcinosarcoma in Late Recurrence of Urothelial Carcinoma after Transurethral Resection

A Case of Early Stage Bladder Carcinosarcoma in Late Recurrence of Urothelial Carcinoma after Transurethral Resection

Sarcomatoid squamous cell carcinoma of urinary bladder

Sarcomatoid Carcinoma of the Urinary Bladder: A Case Report and Review of the Literature

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