Carcinogenicity of formaldehyde and hydrogen chloride in rats

Sellakumar, Arthur R.; Snyder, Carroll A.; Solomon, Jerome J.; Albert, Roy E.

doi:10.1016/0041-008x(85)90411-9

Cited by 75 publications

(36 citation statements)

References 13 publications

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“…That's why the localization of FA toxicity in the upper respiratory tract of rats and the absence of distant site toxicity are consistent with the high reactivity and rapid metabolism of inhaled FA. Distant site toxicity associated with FA exposure has not been observed in at least four inhalation bioassays of FA (Monticello and Morgan, 1989;Appelman et al, 1988;Woutersen et al, 1987;Sellakumar et al, 1985;Kerns et al, 1983). So there is no evidence of genuine systemic toxicity.…”

Section: Discussionmentioning

confidence: 99%

Gross and histomorphological effects of formaldehyde on brain and lungs of Swiss albino mice

Afrin

Amin

et al. 2016

Asian J. Med. Biol. Res

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Formaldehyde (FA) is toxic over a range of doses and of particular concern to anatomists and medical students on laboratory use. FA induces several characteristics of neurotoxicity in addition to systemic effects. Therefore, to know the toxic effects of FA on brain and lungs, mice were collected from international center for diarrheal disease research. They were divided into four groups i.e. control, inhalation, oral and intraperitoneal. The inhalation, oral and intraperitoneal exposure groups further divided into three subgroups which were subjected to exposure of FA daily for 30 days in case of inhalation and oral groups and 10 days in intraperitoneal group for acute toxic effects. Morphological study showed gross abnormalities i.e. congestion on lungs. But no gross abnormal features observed on brain. In 5 ppm treated inhaled group, lungs tissue revealed hemorrhages. In the inhaled groups, brain tissue showed degenerating neurons with either pyknotic or karyorrhectic nuclei are gradually increased in highest concentration group. These data supports the view that FA has adverse effects on the morphology of brain and lungs.

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Section: Discussionmentioning

confidence: 99%

Gross and histomorphological effects of formaldehyde on brain and lungs of Swiss albino mice

Afrin

Amin

et al. 2016

Asian J. Med. Biol. Res

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“…It is also worthwhile to acknowledge that -in contrast to the animal cancer tests in which chemicals are administered at the maximal tolerated dose (31) -some of the levels of formaldehyde exposure scheduled in the animal carcinogenicity tests (27,(32)(33)(34) that induced tumors in nasal passages of rats were in the range of realistic workplace exposures. Extrapolation between species poses problems , however, as usual.…”

Section: Discussionmentioning

confidence: 99%

Formaldehyde exposure and respiratory cancer--a meta-analysis of the epidemiologic evidence.

Partanen¹

1993

Scand J Work Environ Health

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“…2 animals, but limited evidence for humans (4). Another group co ncluded that th e evidence fo r the carcinogenicity of formaldeh yde in humans was less per suasive th an did IARC (5).…”

mentioning

confidence: 99%

Epidemiologic evidence on the relationship between formaldehyde exposure and cancer.

Blair¹,

Saracci²,

Stewart³

et al. 1990

Scand J Work Environ Health

125

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Carcinogenicity of formaldehyde and hydrogen chloride in rats

Cited by 75 publications

References 13 publications

Gross and histomorphological effects of formaldehyde on brain and lungs of Swiss albino mice

Gross and histomorphological effects of formaldehyde on brain and lungs of Swiss albino mice

Formaldehyde exposure and respiratory cancer--a meta-analysis of the epidemiologic evidence.

Epidemiologic evidence on the relationship between formaldehyde exposure and cancer.

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