Epidemiologic evidence on the relationship between formaldehyde exposure and cancer.

Blair, Aaron; Saracci, Rodolfo; Stewart, Patricia A.; Hayes, Richard B.; Shy, Carl M.

doi:10.5271/sjweh.1767

Cited by 128 publications

(61 citation statements)

References 47 publications

(81 reference statements)

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“…Cancer of the nasal cavity or nasopharynx has been linked to exposure to formaldehyde [Hayes et al, 1986;Blair et al, 1990a;Olsen et al, 19841. However, nasal cancer is a very rare disease, and the present study has small power to detect an excess risk.…”

Section: Discussionmentioning

confidence: 99%

Mortality among workers at a plastics manufacturing and research and development facility: 1946–1988

Dell

Teta²

1995

American J Industrial Med

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Mortality through 1988 was studied for 5,932 male employees who worked between January 1, 1946 and December 31, 1967 at a New Jersey plastics manufacturing and research and development facility. The cohort was followed for an average of 32 years and included 1,859 deaths. Potential exposures included asbestos, formaldehyde, and polyvinyl chloride (PVC). Mortality rates for the cohort were compared to both U.S. and state mortality rates, and analyses were also performed by lagging duration of employment. Based on U.S. rates, mortality among hourly males (n = 3,853) from all cancers was similar to expected [standardized mortality ratio (SMR), 102; 95% confidence interval (CI), 92-114]. Excess mortality among hourly workers was seen for pancreatic cancer (SMR, 146; 95% CI, 95-216) and "malignancies of other parts of the respiratory system" (SMR, 373; 95% CI, 121-870). The latter excess was due entirely to five deaths from pleural mesothelioma. There were no deaths identified due to nasal cavity or nasopharyngeal cancers, or angiosarcoma of the liver. Mortality from leukemia among research and development workers (n = 1,421) was significantly elevated (SMR, 265; 95% CI, 115-524) and related to assignment to process development. This study verifies the excess of pancreatic cancer among workers at the facility seen in earlier studies and observes excesses of mesothelioma due to asbestos exposure and leukemia in process development workers.

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Section: Discussionmentioning

confidence: 99%

Mortality among workers at a plastics manufacturing and research and development facility: 1946–1988

Dell

Teta²

1995

American J Industrial Med

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“…Inhaled formaldehyde forms DNA and DNA-protein cross-links in the nasal respiratory mucosa (22). Studies in workers occupationally exposed to formaldehyde have consistently noted a higher incidence of leukemia (23).…”

Section: Formaldehydementioning

confidence: 99%

Biomass fuel exposure and respiratory diseases in India

Prasad¹

2012

Biosci Trends

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“…17 Statistically significant excesses in mortality from cancers of the buccal cavity and connective tissue were found among exposed workers. 17,18 NIOSH has identified formaldehyde as a suspected human carcinogen and recommended that exposures be reduced to the lowest feasible concentra-tion. The OSHA PEL is 0.75 ppm as an 8-hour TWA and 2 ppm as a STEL.…”

Section: Formaldehydementioning

confidence: 99%

Health hazard evaluation report: HETA-94-0023-2473, Veterans Administration, White River Junction, Vermont.

1994

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Epidemiologic evidence on the relationship between formaldehyde exposure and cancer.

Cited by 128 publications

References 47 publications

Mortality among workers at a plastics manufacturing and research and development facility: 1946–1988

Mortality among workers at a plastics manufacturing and research and development facility: 1946–1988

Biomass fuel exposure and respiratory diseases in India

Health hazard evaluation report: HETA-94-0023-2473, Veterans Administration, White River Junction, Vermont.

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