Carbon Paste- and PVC Membrane Electrodes as Sensitive Sensors for the Determination of Antidiabetic Drugs for Type 2 Diabetic Patients

Badawy, W. A.; El-Ries, M. A.; Mahdi, Inas M.

doi:10.2116/analsci.25.1431

Cited by 13 publications

(3 citation statements)

References 28 publications

(26 reference statements)

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“…Potentiometric sensor for quantitative analysis of PIO was developed by Faridbod et al [15] who selected pioglitazone–tetraphenyl borate as a suitable ion-pair reagent in making potentiometric PVC membrane sensor for PIO. The proposed method showed a wide linear range of 10 −5 –10 −2 M and detection limit of 6.0×10 −6 M. Badawy et al [16] quantified rosiglitazone, PIO, glimepiride and glyburide conveniently and economically using cyclic voltammetry and differential pulse voltammetry. The authors used carbon paste and glassy carbon electrodes as sensors for these drugs in Briton–Robinson as buffer solution.…”

Section: Methodsmentioning

confidence: 99%

Pioglitazone: A review of analytical methods

Satheeshkumar

Saladi

Srinivas

2014

Journal of Pharmaceutical Analysis

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Pioglitazone is an oral anti-hyperglycemic agent. It is used for the treatment of diabetes mellitus type 2. It selectively stimulates nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-gamma). It was the tenth-best-selling drug in the U.S. in 2008. This article examines published analytical methods reported so far in the literature for the determination of pioglitazone in biological samples and pharmaceutical formulations. They include various techniques like electrochemical methods, spectrophotometry, capillary electrophoresis, high-performance liquid chromatography, liquid chromatography–electrospray ionization-tandem mass spectrometry and high-performance thin layer chromatography.

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Section: Methodsmentioning

confidence: 99%

Pioglitazone: A review of analytical methods

Satheeshkumar

Saladi

Srinivas

2014

Journal of Pharmaceutical Analysis

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“…reviewed. 4 Various techniques such as uv-spectrophotometry, [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] potentiometry, voltammetry, [27][28] high-performance liquid chromatography, [29][30][31][32][33][34][35][36][37][38][39] ultra-performance liquid chromatography, 40 highperformance thin layer chromatography [41][42][43][44][45][46] and capillary electrophoresis 47 have been reported for the determination of PGH in bulk sampleand tablets.…”

Section: Pioglitazone Hydrochloride (Pgh) Chemically Known As 5-[[4-mentioning

confidence: 99%

Spectrophotometric assay of pioglitazone hydrochloride using permanganate in acidic and basic media

Basavaiah¹,

Rajendraprasad²

2018

10.5267/j.ccl

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Pioglitazone hydrochloride (PGH) is an oral anti-hyperglycemic agent used in the treatment of type-2 diabetes mellitus. Potassium permanganate was found to oxidize PGH both in acidic and basic conditions, based on which two simple and sensitive methods were developed for its determination in bulk sample and tablets, and validated. In the first method (indirect method), PGH was reacted with a measured excess of standard permanganate in H2SO4 medium, and the residual oxidant was determined by measuring its absorbance at 550 nm. The second method (Direct method) entails treating PGH with permanganate in NaOH medium, followed by the measurement of the resulting bluish-green manganite at 610 nm. Experimental variables affecting the reactions were studied and optimized. Under optimum conditions, linear relationships with good correlation coefficients were found between absorbance and concentration in the ranges, 1.25 -25 µg mL -1 (Indirect method) and 1-12 µg mL -1 (Direct method) with respective molar absorptivity values of 1.10 × 10 4 and 2.77 × 10 4 l mol -1 cm -1 . The limits of detection (LOD) and quantification (LOQ) were 0.36 and 1.08 (Indirect method) and 0.23 and 0.69 µg mL -1 (Direct method). Intra-day and inter-day precisions were satisfactory, with %RSD values of ≤2.11, and the respective accuracies were excellent with %RE values of ≤2. The methods were also validated for robustness, ruggedness and selectivity. The methods were applied to the determination of PGH in its tablets with good accuracy and precision, and no interference from the tablet additives was encountered. The results were also compared with those obtained by a reference method.

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“…These include sensors for dextromethorphan, a highly effective non-opioid antitussive drug (reineckate salt or phosphomolybdate electroactive agents) [280], for oxybutynin hydrochloride and flavoxate hydrochloride urogenital system drugs (reineckate salt or tungstophosphate) [281] or antidiabetic drugs were also determined by carbon paste-based and PVC membrane-based ISEs (reineckate salt or tungstophosphate) [282].…”

Section: Potentiometric Sensors Containing New Ion-exchange Componentsmentioning

confidence: 99%

Bioelectroanalysis of pharmaceutical compounds

et al. 2012

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Recent developments in the bioelectroanalysis of pharmaceutical compounds are reviewed, concentrating particularly on the development of electrode materials and measurement strategies and on their application. The advantages of electroanalytical techniques as alternatives to other analytical procedures such as rapid response, sensitivity and low detection limits are highlighted and illustrated. Particular emphasis is given to carbon-based materials for voltammetric electroanalysis; new potentiometric sensors and electrochemical biosensors are also reviewed.

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Carbon Paste- and PVC Membrane Electrodes as Sensitive Sensors for the Determination of Antidiabetic Drugs for Type 2 Diabetic Patients

Abstract: The antidiabetic drugs under investigations, either as standard materials or in pharmaceutical preparations are rosiglitazone, R, of molecular formula, C18H19N3O3S,

Cited by 13 publications

References 28 publications

Pioglitazone: A review of analytical methods

Pioglitazone: A review of analytical methods

Spectrophotometric assay of pioglitazone hydrochloride using permanganate in acidic and basic media

Bioelectroanalysis of pharmaceutical compounds

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