Pioglitazone: A review of analytical methods

Satheeshkumar, N.; Saladi, Shantikumar; Srinivas, R.

doi:10.1016/j.jpha.2014.02.002

Cited by 38 publications

(30 citation statements)

References 35 publications

(43 reference statements)

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“…The importance of sample preparation in analytical methods was best reviewed by Satheeshkumar et al [15]. It is influenced by chemical nature of biomarker, extraction method employed, particle size of sample, and presence of interfering substances.…”

Section: Optimization Of Sample Preparationmentioning

confidence: 99%

Identification and Quantification of Aldose Reductase Inhibitory Flavonoids in Herbal Formulation and Extract of Gymnema sylvestre Using HPLC-PDA and LC-MS/MS

Satheeshkumar

Saladi

Komali

2014

Chromatography Research International

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Adulteration of herbal supplements is a major issue for many countries. A simple and reliable HPLC-PDA method was developed for quantification of aldose reductase inhibitory flavonoids rutin, quercetin, and kaempferol. The chromatographic separation was performed on a Fortis C 18 column in gradient mode with detection at 267 nm. The presence of these markers was confirmed through the accurate m/z values and MS/MS data obtained using quadruple time of flight mass spectrometry (QTOF-MS). The proposed method was successfully applied to examine the amount of these active constituents in antiobese polyherbal formulation and plant extract of Gymnema sylvestre.

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Section: Optimization Of Sample Preparationmentioning

confidence: 99%

Identification and Quantification of Aldose Reductase Inhibitory Flavonoids in Herbal Formulation and Extract of Gymnema sylvestre Using HPLC-PDA and LC-MS/MS

Satheeshkumar

Saladi

Komali

2014

Chromatography Research International

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“…The results of interactions are the loss of occupancy from the localized NBO of the idealized Lewis structure into an empty non-Lewis orbital. For each donor (i) and acceptor(j), the stabilization energy E (2) associated with the delocalization i→ j is estimated as ⁄ Where q i is the donor orbital occupancy,  i ,  j are diagonal elements and F (i, j) is the offdiagonal NBO Fock matrix element. The perturbation energies of significant donor -acceptor interactions are presented in Table3.…”

Section: Nbo Analysismentioning

confidence: 99%

“…The perturbation energies of significant donor -acceptor interactions are presented in Table3. In NBO analysis, larger E (2) values shows the intensive interaction between electron donors and electron acceptors and greater the extent of conjugation of the whole system. For this label molecule the interactions π *(C 18 -N 23 ) → π *(C 19 -C 20 ) has thehighest E (2) value around 170.65 Kcal/mol.…”

Section: Nbo Analysismentioning

confidence: 99%

Vibrational and Molecular Structural Investigations of Pioglitazone Combined Study of Experimental and Quantum Chemical Calculations (Density Functional Theory)

Rajesh¹,

Gunasekaran²,

Rajesh³

2018

IJCTR

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The Fourier transform-Raman (FT-Raman) and Fourier transform infrared (FT-IR) spectra of (RS)-5-(4-[2-(5-ethylpyridin-2-yl) ethoxy] benzyl) thiazolidine-2,4-dione (pioglitazone) were studied in the region of 4000-100 cm-1 and 4000-400 cm-1 respectively. The theoretical spectral investigation of pioglitazone are also carried out by using density functional theory (DFT) with 6-31G (d,p) basis set. Experimental and theoretical values are compared. The entire vibrational assignments were carried out on the basis of the potential energy distribution (PED) of the vibrational modes using VEDA 4 program. The optimized geometry of the compound was calculated from the DFT-B3LYP. HOMO-LUMO energy gap has been calculated. The molecular geometry parameters like bond angle and bond length have been computed. The molecular stability arising from hyper conjugative interaction, charge delocalization has been analyzed using natural bond orbital (NBO) analysis. The Mullikan atomic charges have been computed. The molecular electrostatic potential (MEP) are also carried out to study the molecular interactions in the title molecule.

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“…reviewed. 4 Various techniques such as uv-spectrophotometry, [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] potentiometry, voltammetry, [27][28] high-performance liquid chromatography, [29][30][31][32][33][34][35][36][37][38][39] ultra-performance liquid chromatography, 40 highperformance thin layer chromatography [41][42][43][44][45][46] and capillary electrophoresis 47 have been reported for the determination of PGH in bulk sampleand tablets.…”

Section: Pioglitazone Hydrochloride (Pgh) Chemically Known As 5-[[4-mentioning

confidence: 99%

Spectrophotometric assay of pioglitazone hydrochloride using permanganate in acidic and basic media

Basavaiah¹,

Rajendraprasad²

2018

10.5267/j.ccl

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Pioglitazone hydrochloride (PGH) is an oral anti-hyperglycemic agent used in the treatment of type-2 diabetes mellitus. Potassium permanganate was found to oxidize PGH both in acidic and basic conditions, based on which two simple and sensitive methods were developed for its determination in bulk sample and tablets, and validated. In the first method (indirect method), PGH was reacted with a measured excess of standard permanganate in H2SO4 medium, and the residual oxidant was determined by measuring its absorbance at 550 nm. The second method (Direct method) entails treating PGH with permanganate in NaOH medium, followed by the measurement of the resulting bluish-green manganite at 610 nm. Experimental variables affecting the reactions were studied and optimized. Under optimum conditions, linear relationships with good correlation coefficients were found between absorbance and concentration in the ranges, 1.25 -25 µg mL -1 (Indirect method) and 1-12 µg mL -1 (Direct method) with respective molar absorptivity values of 1.10 × 10 4 and 2.77 × 10 4 l mol -1 cm -1 . The limits of detection (LOD) and quantification (LOQ) were 0.36 and 1.08 (Indirect method) and 0.23 and 0.69 µg mL -1 (Direct method). Intra-day and inter-day precisions were satisfactory, with %RSD values of ≤2.11, and the respective accuracies were excellent with %RE values of ≤2. The methods were also validated for robustness, ruggedness and selectivity. The methods were applied to the determination of PGH in its tablets with good accuracy and precision, and no interference from the tablet additives was encountered. The results were also compared with those obtained by a reference method.

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Pioglitazone: A review of analytical methods

Cited by 38 publications

References 35 publications

Identification and Quantification of Aldose Reductase Inhibitory Flavonoids in Herbal Formulation and Extract of Gymnema sylvestre Using HPLC-PDA and LC-MS/MS

Identification and Quantification of Aldose Reductase Inhibitory Flavonoids in Herbal Formulation and Extract of Gymnema sylvestre Using HPLC-PDA and LC-MS/MS

Vibrational and Molecular Structural Investigations of Pioglitazone Combined Study of Experimental and Quantum Chemical Calculations (Density Functional Theory)

Spectrophotometric assay of pioglitazone hydrochloride using permanganate in acidic and basic media

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