Can a Cutoff Value for Cystatin C in the Operative Setting Be Determined to Predict Kidney Function After Liver Transplantation?

Nemes, Balázs; Zádori, Gergely; Gelley, Fanni; Gámán, György; Görög, Dénes; Doros, Attila; Sárváry, Enikő

doi:10.1016/j.transproceed.2010.05.009

Cited by 6 publications

(3 citation statements)

References 14 publications

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“…15 Therefore, the urinary concentration of cystatin C is zero. 16 During inflammation, its endogenous production is unaffected. 17 The concentration of this protein is unaffected by sex, age, or body mass.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Renal Function By Cystatin C in Renal Transplant Recipients

Ayub

Zafar²,

Aziz³

et al. 2014

Exp Clin Transplant

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Section: Discussionmentioning

confidence: 99%

Evaluation of Renal Function By Cystatin C in Renal Transplant Recipients

Ayub

Zafar²,

Aziz³

et al. 2014

Exp Clin Transplant

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“…Several GFR estimation methods based on creatinine concentration, such as modification of diet in renal disease (MDRD) or Cockcroft and Gault are used in routine practice but they are not highly correlated to inulin clearance in most patients . Other markers of GFR such as cystatin C or beta‐trace proteins have also been evaluated, especially in renal transplant recipients (RTR) but they still require validation .…”

Section: Introductionmentioning

confidence: 99%

Routine Determination of GFR in Renal Transplant Recipients by HPLC Quantification of Plasma Iohexol Concentrations and Comparison With Estimated GFR

Castagnet¹,

Blasco

Vourc’h

et al. 2012

Clinical Laboratory Analysis

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Estimated glomerular filtration rate (eGFR) methods are not sufficiently reliable in renal transplant recipients (RTR) and should be replaced by iohexol plasma clearance measurement. However, this method has poor availability in health centers. The aim of our study was to develop a high-performance liquid chromatography (HPLC) method for plasma iohexol measurement in routine practice and to evaluate its plasma clearance as a reference of GFR. We developed an HPLC method using UV detection. We evaluated sample storage conditions to provide recommendations for routine practice. Then, we compared GFRbased on plasma iohexol clearance (GFR-iohexol) to eGFR using modification of diet in renal disease, Cockcroft and Gault, and CDK-EPIequations in 40 RTR. The method was validated over a concentration range of 15-300 μg/l. Excellent linearity (r > 0.998), inter- and intraday precision (CV < 3.3%), and accuracy (>96.8%) were complied with ICH guidelines. We also demonstrated excellent samples stability (9 days). Although eGFR methods are not references in RTR, we found a correct concordance between eGFR and GFR-iohexol in our population. To conclude, our method is simple, rapid, accurate, and reliable for routine clinical and research use especially in RTR.

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“…Ezzel szemben a cystatin C szérumszintjének meghatározása egy érzé-kenyebb módszer, aminek mennyiségét a vérben csak a veseműködés befolyásolja. A szerzők korábbi közle-ményükben, a cystatin C tekintetében, statisztikai mód-szerekkel megállapítottak egy "cut off" értéket (1,28 mg/L), amely előre jelzi a májátültetés utáni vesemű-ködés romlását [7].…”

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Kidney function and liver transplantation

et al. 2013

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Bevezetés: Májcirrhosisban a vesefunkció is romlik. Ennek hátterében leggyakrabban hepatorenalis szindróma áll, de primer vesebetegség, diabetes mellitus, valamint egyes alapbetegségek is okozhatják (például hepatitis C-vírus-fertőzés). Májtranszplantáció során számos további esemény (teljes vena cava kirekesztés, politranszfúzió, immunszuppresszió) is eredményezheti a veseműködés romlását. Célkitűzés: A veseműködés változásának vizsgálata máj-transzplantációt követően a posztoperatív első év alatt. Módszer: Primer májátültetésen átesett betegek (n = 319) adatait dolgozták fel retrospektív adatelemzéssel. Eredmények: Ha a veseműködés már preoperatív beszűkült volt, egyes posztoperatív szövődmények gyakrabban alakultak ki, és rosszabb volt az egyéves kumulatív betegtúlélés (91,7% vs. 69,9%; p<0,001). Ha az első év után a glomerulusfi ltrációs ráta 60 ml/perc/1,73 m 2 fölé emelkedett, javult a betegtúlélés. Függetlenül a vese preoperatív állapotától, az első év végig a betegek nagyobb részének (76%) romlott a veseműködése. Ebben a betegcsoportban gyakrabban alakult ki de novo diabetes mellitus (22,5% vs. 9,5%; p = 0,023). Következtetések: A veseelégtelenség kialakulásában jelentős szerepet játszó kockázati tényezők közül leginkább a személyre szabott immunszuppressziós terápia megválasztásán keresztül érhető el kedvező hatás. Orv. Hetil., 2013, 154, 1018-1025 Kulcsszavak: májátültetés, veseműködés, immunszuppresszió, hepatorenalis szindróma, hepatitis C Kidney function and liver transplantationIntroduction: In liver cirrhosis renal function decreases as well. Hepatorenal syndrome is the most frequent cause of the decrease, but primary kidney failure, diabetes mellitus and some diseases underlying endstage liver failure (such as hepatitis C virus infection) can also play an important role. In liver transplantation several further factors (total cross-clamping of vena cava inferior, polytransfusion, immunosuppression) impair the renal function, too. Aim: The aim of this study was to analyse the changes in kidney function during the fi rst postoperative year after liver transplantation. Method: Retrospective data analysis was performed after primary liver transplantations (n = 319). Results: impaired preoperative renal function increased the devepolment of postoperative complications and the fi rst year cumulative patient survival was signifi cantly worse (91,7% vs 69,9%; p<0,001) in this group. If renal function of the patients increased above 60 ml/min/1,73 m 2 after the fi rst year, patient survival was better. Independently of the preoperative kidney function, 76% of the patients had impaired kidney function at the fi rst postoperative year. In this group, de novo diabetes mellitus was more frequently diagnosed (22,5% vs 9,5%; p = 0,023). Conclusions: Selection of personalized immunosuppressive medication has a positive effect on renal function. Orv. Hetil., 2013, 154, 1018-1025

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Can a Cutoff Value for Cystatin C in the Operative Setting Be Determined to Predict Kidney Function After Liver Transplantation?

Cited by 6 publications

References 14 publications

Evaluation of Renal Function By Cystatin C in Renal Transplant Recipients

Evaluation of Renal Function By Cystatin C in Renal Transplant Recipients

Routine Determination of GFR in Renal Transplant Recipients by HPLC Quantification of Plasma Iohexol Concentrations and Comparison With Estimated GFR

Kidney function and liver transplantation

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