Calibration method for a carbon nanotube field-effect transistor biosensor

Abstract

An easy calibration method based on the Langmuir adsorption theory is proposed for a carbon nanotube field-effect transistor (NTFET) biosensor. This method was applied to three NTFET biosensors that had approximately the same structure but exhibited different characteristics. After calibration, their experimentally determined characteristics exhibited a good agreement with the calibration curve. The reason why the observed characteristics of these NTFET biosensors differed among the devices was that the carbon nanotube (CNT) that formed the channel was not uniform. Although the controlled growth of a CNT is difficult, it is shown that an NTFET biosensor can be easy calibrated using the proposed calibration method, regardless of the CNT channel structures.

Chemical and Biosensing Applications Based on Graphene Field-Effect Transistors

“…The Langmuir adsorption isotherm fitted the experimental results well, as shown in Figure 10 (red dashed line). The K d was estimated to be 1.5 × 10 −8 M, which was comparable with the values obtained for Si nanowire (Cui et al, 2001) and CNT-FET biosensors (Abe et al, 2008;Maehashi et al, 2009) using antibody-antigen interactions, despite the fact that BSA molecules were considered to be directly adsorbed onto the graphene surface in this work rather than through a protein-protein interaction. Further experiments are needed to confirm the suitability of the Langmuir adsorption isotherm for these experimental results.…”

Integrations and challenges of novel high-k gate stacks in advanced CMOS technology

“…In order to improve the device performance further, a thinner gate insulator with higher dielectric constant can also be used, such as ZrO 2 and HfO 2 [432,438]. Up-to-now, there are a plenty of efforts to apply Nanowire FETs in different fields, such as biosensors [439], and light detection [431,440,441].…”

Advances of Nanotechnology Applied to Biosensors

“…Field-effect biosensors based on planar [46] structures and nanowires have been fabricated in recent experiments [44]. Masuhiro Abe et al [45]. showed that an NTFET biosensor can be calibrated using the Langmuir adsorption equation.…”