Calcium zeolites as intelligent carriers in controlled release of bisphosphonates

Sandomierski, Mariusz; Zielińska, Maryla; Voelkel, Adam

doi:10.1016/j.ijpharm.2020.119117

Cited by 29 publications

(30 citation statements)

References 36 publications

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“…6 In our previous work, we described ion exchange zeolite materials as intelligent drug carriers. 26 The release time, in that case, was over 90 hours. The presented studies indicate that in the case of rapid release, we should use MMT, while in the case of long release we should use zeolite.…”

Section: Resultsmentioning

confidence: 91%

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Calcium montmorillonite as a potential carrier in the release of bisphosphonates

Sandomierski¹,

Zielińska²,

Adamska³

et al. 2022

New J. Chem.

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Section: Resultsmentioning

confidence: 91%

“…SBF is a solution with high sodium concentration prepared according to previous work. 26 SBF reflects the ionic strength and pH of body fluids such as plasma or intestinal fluid.…”

Section: Simulated Body Fluids (Sbf)mentioning

confidence: 99%

Calcium montmorillonite as a potential carrier in the release of bisphosphonates

Sandomierski¹,

Zielińska²,

Adamska³

et al. 2022

New J. Chem.

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“…Because of the lack of toxic effects, zeolites can be used in some biomedical applications. , Previous studies confirmed the biocompatibility of different types of zeolites . For example, the FAU zeolite has no effect on the cell viability, which allowed its use as a carrier for cancer drugs .…”

Section: Introductionmentioning

confidence: 98%

Calcium-Rich 13X Zeolite as a Filler with Remineralizing Potential for Dental Composites

Buchwald

Sandomierski

Voelkel

2020

ACS Biomater. Sci. Eng.

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A zeolite with high ion-exchange potential was used as an active filler with remineralizing potential in composites that can be applied in restorative dentistry. Two calcium-rich forms of the 13X zeolite were obtained by sodium to calcium ion exchange and mineralization of a hydroxyapatite layer. These fillers were also silanized and mixed with methacrylic resins and photoinitiators to obtain composite materials. First, the effectiveness of the filler preparation and silanization was confirmed by X-ray diffractometry, scanning electron microscopy, energy dispersive spectroscopy, transmission electron microscopy, nitrogen adsorption/desorption measurements, thermogravimetric analysis, and Fourier transform infrared spectroscopy. The physicochemical characteristics of composites with silanized and nonsilanized forms of sodium- and calcium-rich 13X zeolite fillers were examined. The degree of conversion, depth of cure, flexural and compressive strength, mass stability, and remineralizing potential, understood as the ability to release calcium ions in the conditions simulating a natural oral environment, were determined. The effect of ion exchange, hydroxyapatite mineralization, and silanization of fillers on the final composites’ properties was examined. Composites with calcium-rich fillers proved to show the ability to release Ca2+ during incubation in saline for 14 days at 36.6 °C showing therefore remineralizing potential with good values of other parameters.

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“…The materials considered during the selection of a carrier in the controlled release of bisphosphonates should have divalent cations in their structure, as we have proven in previous work 31 . This is caused by strong interactions between divalent cations and the phosphonium groups of bisphosphonates 32 .…”

Section: Introductionmentioning

confidence: 99%

Zeolitic Imidazolate Framework‑8 (ZIF-8) modified titanium alloy for controlled release of drugs for osteoporosis

Sandomierski

Jakubowski

Ratajczak

et al. 2022

Sci Rep

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The aim of this work was to prepare a biocompatible implant material that enables the release of drug for osteoporosis—risedronate. To achieve this goal, a titanium implant coated with a biocompatible Zeolitic Imidazolate Framework 8 (ZIF-8) layer was prepared that promotes osseointegration at the bone-implant interface. The modifications of the titanium alloy as well as sorption and desorption processes were confirmed using a variety of methods: SEM, EDS XPS, and FT-IR imaging (to determine surface modification, drug distribution, and risedronate sorption), and UV–Vis spectroscopy (to determine drug sorption and release profile). Both the ZIF-8 layer and the drug are evenly distributed on the surface of the titanium alloy. The obtained ZIF-8 layer did not contain impurities and zinc ions were strongly bounded by ZIF-8 layer. The ZIF-8 layer was stable during drug sorption. The drug was released in small doses for 16 h, which may help patients recover immediately after surgery. This is the first case of using ZIF-8 on the surface of the titanium alloy as carrier that releases the drug under the influence of body fluids directly at the site of the disease. It is an ideal material for implants designed for people suffering from osteoporosis.

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Calcium zeolites as intelligent carriers in controlled release of bisphosphonates

Cited by 29 publications

References 36 publications

Calcium montmorillonite as a potential carrier in the release of bisphosphonates

Calcium montmorillonite as a potential carrier in the release of bisphosphonates

Calcium-Rich 13X Zeolite as a Filler with Remineralizing Potential for Dental Composites

Zeolitic Imidazolate Framework‑8 (ZIF-8) modified titanium alloy for controlled release of drugs for osteoporosis

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