Calcium montmorillonite as a potential carrier in the release of bisphosphonates

Sandomierski, Mariusz; Zielińska, Maryla; Adamska, Katarzyna; Patalas, Adam; Voelkel, Adam

doi:10.1039/d1nj04268h

Cited by 6 publications

(4 citation statements)

References 41 publications

(39 reference statements)

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“…Clay minerals with a nanostructure such as montmorillonite (MMT) have become increasingly popular in dentistry. It is a layered phyllosilicate [29], 2:1 sheet structure, in which two layers (octahedral and tetrahedral) are fused [29][30][31]. The incorporation of clay nanoparticles in dental restorative materials may have a positive effect on their mechanical, thermal, and adhesive properties, as well as on ion exchange and their antibacterial activity [9,32,33].…”

Section: Introductionmentioning

confidence: 99%

An Evaluation of Experimental Calcium Ion-Leachable Nanocomposite Glass Ionomer Cements

Tsolianos,

Nikolaidis,

Koulaouzidou

et al. 2023

Nanomaterials

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Glass ionomer cements (GICs) are among the main restorative dental materials used broadly in daily clinical practice. The incorporation of clay nanoparticles as reinforcing agents is one potential approach to improving GIC properties. This study aims to investigate whether the incorporation of calcium-modified clay (Ca-clay) nanoparticles in conventional GICs alters their structural characteristics, along with their physicochemical and mechanical properties. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) analyses were performed to assess the surface characterization of GIC nanocomposites, whereas a setting reaction was carried out via an attenuated total reflection Fourier transform infrared spectrometer (ATR-FTIR). A universal testing machine was used for compression tests, while calcium ion release was quantified using inductively coupled plasma optical emission spectrometry (ICP-OES). GIC composite groups reinforced with Ca-clay were found to release a fine amount of calcium ions (5.06–9.91 ppm), with the setting reaction being unaffected for low Ca-clay loadings. The median compressive strength of 3 wt% in the Ca-clay group (68.97 MPa) was nearly doubled compared to that of the control group (33.65 MPa). The incorporation of Ca-clay nanoparticles in GICs offers a promising alternative among dental restorative materials regarding their chemical and mechanical properties.

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Section: Introductionmentioning

confidence: 99%

An Evaluation of Experimental Calcium Ion-Leachable Nanocomposite Glass Ionomer Cements

Tsolianos,

Nikolaidis,

Koulaouzidou

et al. 2023

Nanomaterials

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“…So, the addition of clays has gained considerable attention. As clays are nontoxic, their composites can be used in biomedical applications such as tissue engineering, bone cement, wound healing, drug delivery, and enzyme immobilization [7]. As bone tissue engineering (BTE) is mainly based on the formation of tissues and bone mechanics, scaffolds, cells, and growth factors are the three main components of BTE.…”

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite–Clay Composite for Bone Tissue Engineering: Effective Utilization of Prawn Exoskeleton Biowaste

Satish,

Hadagalli,

Praveen

et al. 2023

Inorganics

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Hydroxyapatite (HA, Ca10(PO4)6(OH)2)-based porous scaffolds have been widely investigated in the last three decades. HA, with excellent biocompatibility and osteoconductivity, has made this material widely used in bone tissue engineering. To improve the mechano-biological properties of HA, the addition of clay to develop HA-based composite scaffolds has gained considerable interest from researchers. In this study, a cost-effective method to prepare a HA–clay composite was demonstrated via the mechanical mixing method, wherein kaolin was used because of its biocompatibility. Prawn (Fenneropenaeus indicus) exoskeleton biowaste was utilized as a raw source to synthesize pure HA using wet chemical synthesis. HA–clay composites were prepared by reinforcing HA with 10, 20, and 30 wt.% of kaolin via the mechanical mixing method. A series of characterization tools such as XRD, FTIR, Raman, and FESEM analysis confirmed the phases and characteristic structural and vibrations bonds along with the morphology of sintered bare HA, HA–kaolin clay composite, and kaolin alone, respectively. The HA–clay composite pellets, uniaxially pressed and sintered at 1100 °C for 2 h, were subjected to a compression test, and an enhancement in mechanical and physical properties, with the highest compressive strength of 35 MPa and a retained open porosity of 33%, was achieved in the HA–kaolin (20 wt.%) clay composite, in comparison with bare HA. The addition of 20% kaolin to HA enhanced its compressive strength by 33.7% and increased its open porosity by 19% when compared with bare HA. The reinforcement of HA with different amounts (10, 20, 30 wt.%) of kaolin could open up a new direction of preparing biocomposite scaffolds with enhanced mechanical properties, improved wear, and better cell proliferation in the field of bone tissue engineering.

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“…Porous materials such as clay minerals including smectite family (e.g. montmorillonite, bentonite) are crystalline aluminosilicates, attractive for drug release applications owing to their large surface area and tunable surface chemistry 22,23 . Interestingly, zeolite is another class of crystalline aluminosilicates made from connected TO4 tetrahedra where T denotes either an Al or Si atom, which form a regular microporous structure during the synthesis 24 .…”

Section: Introductionmentioning

confidence: 99%

“…montmorillonite and bentonite) are crystalline aluminosilicates and are attractive for drug release applications owing to their large surface area and tunable surface chemistry. 22,23 Interestingly, zeolite is another class of crystalline aluminosilicates made from connected TO 4 tetrahedra where T denotes either an Al or Si atom, which form a regular microporous structure during synthesis. 24 Zeolites are wide-spread in the industry as catalysts, molecular sieves or sorbents 25 since their pore dimensions, surface areas, and sorption capacity can be hierarchized according to the synthesis route.…”

Section: Introductionmentioning

confidence: 99%

Deciphering the role of faujasite-type zeolites as a cation delivery platform to sustain the functions of MC3T3-E1 pre-osteoblastic cells

et al. 2022

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Calcium montmorillonite as a potential carrier in the release of bisphosphonates

Abstract: There is a strong need to search for more effective bisphosphonates carriers which will lead to increased bioavailability of bone tissue engineering. Montmorillonite and calcium montmorillonite were used as risedronate...

Cited by 6 publications

References 41 publications

An Evaluation of Experimental Calcium Ion-Leachable Nanocomposite Glass Ionomer Cements

An Evaluation of Experimental Calcium Ion-Leachable Nanocomposite Glass Ionomer Cements

Hydroxyapatite–Clay Composite for Bone Tissue Engineering: Effective Utilization of Prawn Exoskeleton Biowaste

Deciphering the role of faujasite-type zeolites as a cation delivery platform to sustain the functions of MC3T3-E1 pre-osteoblastic cells

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