Zeolitic Imidazolate Framework‑8 (ZIF-8) modified titanium alloy for controlled release of drugs for osteoporosis

Abstract

The aim of this work was to prepare a biocompatible implant material that enables the release of drug for osteoporosis—risedronate. To achieve this goal, a titanium implant coated with a biocompatible Zeolitic Imidazolate Framework 8 (ZIF-8) layer was prepared that promotes osseointegration at the bone-implant interface. The modifications of the titanium alloy as well as sorption and desorption processes were confirmed using a variety of methods: SEM, EDS XPS, and FT-IR imaging (to determine surface modification, drug distribution, and risedronate sorption), and UV–Vis spectroscopy (to determine drug sorption and release profile). Both the ZIF-8 layer and the drug are evenly distributed on the surface of the titanium alloy. The obtained ZIF-8 layer did not contain impurities and zinc ions were strongly bounded by ZIF-8 layer. The ZIF-8 layer was stable during drug sorption. The drug was released in small doses for 16 h, which may help patients recover immediately after surgery. This is the first case of using ZIF-8 on the surface of the titanium alloy as carrier that releases the drug under the influence of body fluids directly at the site of the disease. It is an ideal material for implants designed for people suffering from osteoporosis.

Synthesis of Hierarchical Mesoporous ZIF-8 Functionalized with 1,2,4-Triazole by Mixed-Ligand Strategy for Enhanced CO2 Fixation Under Atmospheric Pressure

“…Furthermore, the high-resolution N 1s spectra showed a peak at 398.4 eV in ZIF-8, while for the ZIF-8T catalysts, the N 1s peak shifted to a higher binding energy with increasing T ligand contents in ZIF-8T (Figure S8a). This result indicates that the addition of T ligands in ZIF-8T with an abundance of nitrogen atoms affects Zn–N bonding and free nitrogen . The N 1s peak in ZIF-8 can be deconvoluted into three peaks corresponding to −N–C, −N–Zn, −NH, , while ZIF-8T materials exhibits four peaks assigned to −N–C, −N–Zn, −N–N, and −NH (Figure S8b–f).…”

Debridement of contaminated implants using air-polishing coupled with pH-responsive maximin H5-embedded metal-organic frameworks

“…Here, ZIF-8 NPs in the culture medium agglomerated and precipitated frequently on the SLA surfaces after the pretreatment of MH5C@ZIF-8 for 24 h, which was somewhat similar to ZIF-8 coatings on titanium surfaces ( Liu et al, 2020b ). Previous studies exhibited that the functionalized ZIF-8 coatings deposited on titanium promoted the viabilities and the osteogenic property of osteogenic cells ( Sandomierski et al, 2022 ). Another study also demonstrated that ZIF-8-coated titanium surfaces enhanced the osteogenesis of the osteoblast and promoted new bone formations ( Zhang et al, 2017 ).…”

In situ encapsulation of V2O5@ZIF-8 nanocomposites as electrode materials for high-performance supercapacitors with long term cycling stability

“…26 The overall performance of ZIF-based composites is expected to achieve further improvements in terms of synergistic effects by integrating the advantages of various components. 31 Considering that the properties of composites are mainly related to the types of components and interactions between separated components, the basic principle of construction is important for composites based on ZIF-8. 32 Some reported nanoscale material decorated ZIF-8 based composites have been developed for various applications such as Fe 2 O 3 @ZIF-8, 33 SnO 2 quantum dots@ZIF-8, 34 Fe 3 O 4 @ ZIF-8, 35 ZIF-8@reduced graphene oxide, 36,37 TiO 2 -ZIF-8, 38 Cu@ C@ZIF-8, 39 ZIF-8/polyaniline 40 and polypyrrole/ZIF-8.…”