Calcium Ion-Sodium Alginate-Piperine-Based Microspheres: Evidence of Enhanced Encapsulation Efficiency, Bio-Adhesion, Controlled Delivery, and Oral Bioavailability of Isoniazid

Telange, Darshan R.; Pandharinath, Ravindra R; Pethe, Anil M.; Jain, Shirish P.

doi:10.1208/s12249-022-02236-6

Cited by 12 publications

(9 citation statements)

References 57 publications

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“…Alginate was used as the material; alginate can be rapidly gelled in the presence of multivalent cations such as Ca 2+ and Ba 2+ ions. 58 Alginate-based microparticles are often used as carriers for drug delivery 59 and scaffold materials for cell culture. 60,61 The scheme for producing Ca-alg particles is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Pushing the limits of microfluidic droplet production efficiency: engineering microchannels with seamlessly implemented 3D inverse colloidal crystals

Mashiyama,

Hemmi,

Sato

et al. 2024

Lab Chip

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Section: Resultsmentioning

confidence: 99%

Pushing the limits of microfluidic droplet production efficiency: engineering microchannels with seamlessly implemented 3D inverse colloidal crystals

Mashiyama,

Hemmi,

Sato

et al. 2024

Lab Chip

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“…The sign elucidates the change in dependent responses with a positive sign indicating a synergistic/positive effect and a negative sign showing an antagonistic effect. The positive sign in Equations (1)–(3) with X 1 and X 2 shows that as the concentration of PAG and ALG increases, the particle size, %EE and % yield increase [ 68 ].…”

Section: Resultsmentioning

confidence: 99%

Prunus armeniaca Gum-Alginate Polymeric Microspheres to Enhance the Bioavailability of Tramadol Hydrochloride: Formulation and Evaluation

et al. 2022

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Combinations of polymers can improve the functional properties of microspheres to achieve desired therapeutic goals. Hence, the present study aimed to formulate Prunus armeniaca gum (PAG) and sodium alginate microsphere for sustained drug release. Blended and coated microspheres were prepared using the ionotropic gelation technique. The effect of polymer concentration variation was studied on the structural and functional properties of formulated microspheres. FTIR, XRD, and thermal analysis were performed to characterize the microspheres. All the formulations were well-formed spherical beads having an average diameter from 579.23 ± 07.09 to 657.67 ± 08.74 μm. Microspheres entrapped drugs within the range 65.86 ± 0.26–83.74 ± 0.79%. The pH-dependent swelling index of coated formulations was higher than blended. FTIR spectra confirmed the presence of characteristic peaks of entrapped Tramadol hydrochloride showing no drug-polymer interaction. In vitro drug release profile showed sustained release following the Korsmeyer-Peppas kinetic model with an R2 value of 0.9803–0.9966. An acute toxicology study employing the oral route in Swiss albino mice showed no signs of toxicity. It can be inferred from these results that blending PAG with sodium alginate can enhance the stability of alginate microspheres and improve its drug release profile by prolonging the release time.

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“…In addition, the concentration of Alg solution affect the loading rate and encapsulation rate of the microspheres. When the Alg concentration was less than 4%, the drug loading rate and encapsulation rate of microspheres gradually increased, and after more than 4%, the drug loading rate and encapsulation rate decreased with the increase in Alg concentration [ 89 ].…”

Section: The Materials For Microspheresmentioning

confidence: 99%

Application of Biomedical Microspheres in Wound Healing

Yang

Zhang

Gan

et al. 2023

IJMS

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Tissue injury, one of the most common traumatic injuries in daily life, easily leads to secondary wound infections. To promote wound healing and reduce scarring, various kinds of wound dressings, such as gauze, bandages, sponges, patches, and microspheres, have been developed for wound healing. Among them, microsphere-based tissue dressings have attracted increasing attention due to the advantage of easy to fabricate, excellent physicochemical performance and superior drug release ability. In this review, we first introduced the common methods for microspheres preparation, such as emulsification-solvent method, electrospray method, microfluidic technology as well as phase separation methods. Next, we summarized the common biomaterials for the fabrication of the microspheres including natural polymers and synthetic polymers. Then, we presented the application of the various microspheres from different processing methods in wound healing and other applications. Finally, we analyzed the limitations and discussed the future development direction of microspheres in the future.

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Calcium Ion-Sodium Alginate-Piperine-Based Microspheres: Evidence of Enhanced Encapsulation Efficiency, Bio-Adhesion, Controlled Delivery, and Oral Bioavailability of Isoniazid

Cited by 12 publications

References 57 publications

Pushing the limits of microfluidic droplet production efficiency: engineering microchannels with seamlessly implemented 3D inverse colloidal crystals

Pushing the limits of microfluidic droplet production efficiency: engineering microchannels with seamlessly implemented 3D inverse colloidal crystals

Prunus armeniaca Gum-Alginate Polymeric Microspheres to Enhance the Bioavailability of Tramadol Hydrochloride: Formulation and Evaluation

Application of Biomedical Microspheres in Wound Healing

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