Prunus armeniaca Gum-Alginate Polymeric Microspheres to Enhance the Bioavailability of Tramadol Hydrochloride: Formulation and Evaluation

Noureen, Shazia; Noreen, Sobia; Ghumman, Shazia Akram; Batool, Fozia; Hameed, Huma; Hasan, Sara; Noreen, Fozia; Elsherif, Mervat A.; Bukhari, Syed Nasir Abbas

doi:10.3390/pharmaceutics14050916

Cited by 15 publications

(17 citation statements)

References 74 publications

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“…The percentage error was determined for describing the applicability domain of optimizing the mathematical model. The % error values, i.e., 0.62, 1.04, and 2.34, revealed the suitability of the quadratic model obtained by 32-factorial design. , …”

Section: Results and Discussionmentioning

confidence: 81%

“…The parameters that provided minimum PS (mm), highest DEE (%), and maximum R 12h were selected. Additionally, the comparison of the actual and predicted values was carried out to acquire the best PS (mm), DEE (%), and R 12h (%) for the successful optimization of COM/Na-Alg microspheres …”

Section: Methodsmentioning

confidence: 99%

“…Additionally, the comparison of the actual and predicted values was carried out to acquire the best PS (mm), DEE (%), and R 12h (%) for the successful optimization of COM/Na-Alg microspheres. 30 2.10. Evaluation of the Optimized Formulation.…”

Section: Physicochemical Analysis Of Commentioning

confidence: 99%

“…The % error values, i.e., 0.62, 1.04, and 2.34, revealed the suitability of the quadratic model obtained by 32-factorial design. 30,45 3.9. Evaluation of Microspheres.…”

Section: Experimental Design and Optimizationmentioning

confidence: 99%

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Formulation, Statistical Optimization, and In Vivo Pharmacodynamics of Cydonia oblonga Mucilage/Alginate Mucoadhesive Microspheres for the Delivery of Metformin HCl

et al. 2023

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In recent years, attention has shifted toward the utilization of natural polymers for encapsulation and sustained release of health-hazardous drugs. The purpose of this work is to define and assess the sustained delivery potential and mucoadhesive potential of a Cydonia oblonga mucilage (COM) and sodium alginate (Na-Alg)-constituting polymeric delivery carrier of antidiabetic drugs with a specific end goal to retain metformin HCl in the stomach while expanding the drug’s bioavailability. Metformin HCl was encapsulated in mucoadhesive microspheres by an ionic gelation method. Polymers with different combinations were tried, and the resulting mucoadhesive COM/Na-Alg microspheres were assessed for particle size (mm) PS/Y1, drug encapsulation efficiency DEE (%)/Y2, and in vitro percentage cumulative drug release R12h/Y3 using Drug Design Expert software version 10. The response surface methodology by a 32-central composite design predicted optimal synthesis parameters for the microspheres to be 295 mg for COM and 219 mg for Na-Alg. An optimized formulation was prepared under these conditions and used to evaluate the micrometric properties, morphology and structural characteristics, swelling behavior, in vitro drug release, and kinetics. Acute toxicity studies were carried out on blank COM/Na-Alg microspheres to deem them safe for in vivo studies. The DEE (%) was calculated to be 85.8 ± 1.67, whereas scanning electron microscopy (SEM) showed a coarse surface with characteristic wrinkles and cracks with an optical microscopic particle size of 0.96 ± 2.45. The ex vivo tests showed great mucoadhesive properties and good swelling behavior with pH-responsive drug release and a significant reduction in in vivo blood glucose levels. The results advocated the use of optimized microspheres to enhance the bioactivity with a possible dose reduction, making it less symptomatic, reducing the expense of the treatment, and subsequently facilitating better patient compliance.

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Section: Results and Discussionmentioning

confidence: 81%

Section: Methodsmentioning

confidence: 99%

Section: Physicochemical Analysis Of Commentioning

confidence: 99%

“…The % error values, i.e., 0.62, 1.04, and 2.34, revealed the suitability of the quadratic model obtained by 32-factorial design. 30,45 3.9. Evaluation of Microspheres.…”

Section: Experimental Design and Optimizationmentioning

confidence: 99%

See 2 more Smart Citations

Formulation, Statistical Optimization, and In Vivo Pharmacodynamics of Cydonia oblonga Mucilage/Alginate Mucoadhesive Microspheres for the Delivery of Metformin HCl

et al. 2023

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“…The mass fraction of Alg solution is an important factor to affect the characteristics of microspheres. The diameter of microspheres prepared by lower concentrations of Alg is uneven, and some of them exhibit the tailing phenomenon, while higher concentrations of Alg are difficult to use to prepare microspheres due to large viscosity [ 87 , 88 ]. In addition, the concentration of Alg solution affect the loading rate and encapsulation rate of the microspheres.…”

Section: The Materials For Microspheresmentioning

confidence: 99%

Application of Biomedical Microspheres in Wound Healing

Yang

Zhang

Gan

et al. 2023

IJMS

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Tissue injury, one of the most common traumatic injuries in daily life, easily leads to secondary wound infections. To promote wound healing and reduce scarring, various kinds of wound dressings, such as gauze, bandages, sponges, patches, and microspheres, have been developed for wound healing. Among them, microsphere-based tissue dressings have attracted increasing attention due to the advantage of easy to fabricate, excellent physicochemical performance and superior drug release ability. In this review, we first introduced the common methods for microspheres preparation, such as emulsification-solvent method, electrospray method, microfluidic technology as well as phase separation methods. Next, we summarized the common biomaterials for the fabrication of the microspheres including natural polymers and synthetic polymers. Then, we presented the application of the various microspheres from different processing methods in wound healing and other applications. Finally, we analyzed the limitations and discussed the future development direction of microspheres in the future.

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Definition of Design Space for Preparation and Stability of Tramadol Hydrochloride Loaded Nanoparticles Using OFAT Experiments for Infusion in Pain Management

Yildirim,

Savaser,

Esim

et al. 2024

J Clust Sci

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This paper presents an experimental study on preparation of tramadol hydrochloride (TrH) loaded nanoparticles, and stability determination in various infusion solutions. In this study, various nanoparticle preparation parameters based on w/o/w emulsification solvent evaporation method, including stabilizer type, stabilizer concentration, polymer concentration, homogenization speed and initial drug amount were systematically tested to verify their versatility for preparing nanoparticles. Initially both particle size and encapsulation efficiency of nanoparticles were changed significantly with the change in surfactant and polymer ratio (p<0.05). However, homogenization speed only changed particle size (average size 339.3±1.8 nm for 15000 rpm, 318.9±6.4 nm for 20000 rpm and 237.2±7.8 nm for 25000 rpm) (p<0.05) and initial drug concentration is only affected the encapsulation efficiency (34.2±0.7% for 4 mg/mL and 33.2±0.9 for 1.6 mg/mL) (p<0.05). Storage at room temperature for 3 months resulted in an increase in particle size and polydispersity index. Prepared nanoparticles showed the best stability after storage at – 20 °C for in 3 months. Finally, storage of nanoparticles in various infusion solutions resulted an undesirable changes for 6% Hydroxyethyl starch in 0.9% sodium chloride injection, 10% Dextran 40 and 4% Succinyl gelatin solutions. It was shown that an appropriate delivery of TrH loaded PLGA nanoparticles as infusion can be prepared only in water for injection, 20% Mannitol, 0.9% Sodium chloride and 5% Dextrose solutions.

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Prunus armeniaca Gum-Alginate Polymeric Microspheres to Enhance the Bioavailability of Tramadol Hydrochloride: Formulation and Evaluation

Cited by 15 publications

References 74 publications

Formulation, Statistical Optimization, and In Vivo Pharmacodynamics of Cydonia oblonga Mucilage/Alginate Mucoadhesive Microspheres for the Delivery of Metformin HCl

Formulation, Statistical Optimization, and In Vivo Pharmacodynamics of Cydonia oblonga Mucilage/Alginate Mucoadhesive Microspheres for the Delivery of Metformin HCl

Application of Biomedical Microspheres in Wound Healing

Definition of Design Space for Preparation and Stability of Tramadol Hydrochloride Loaded Nanoparticles Using OFAT Experiments for Infusion in Pain Management

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