Biologically Active Polysaccharides fromTylopilus felleus

Kohlmünzer, S; Grzybek, J; Wegiel, J.

doi:10.1055/s-2006-961344

Cited by 3 publications

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“…One of the major groups of metabolites of medicinal importance are polysaccharides derived from Basidiomycota (Kohlmünzer et al 1992;Wasser 2002). Polysaccharides from the sporocarps of Sarcodon imbricatus were separated into three fractions: two neutral and one acidic, and from in vitro cultures into two: an acidic and neutral.…”

Section: Discussionmentioning

confidence: 99%

“…A good example is a glucan from sporocarps of Tylopilus felleus named tylopilan isolated at the Department of Pharmaceutical Botany, Jagiellonian University Collegium Medicum (Defaye et al 1988). Tylopilan showed antitumor activity against transplantable Sarcoma-180 cells in mice (more than 98% inhibition) and glioma cells (Kohlmünzer et al 1980 ). Studies on the polysaccharides isolated from in vitro cultures of these species showed differences in their structure and biological properties.…”

Section: Discussionmentioning

confidence: 99%

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Chemical composition and cytotoxic activity of the polysaccharide fractions in Sarcodon imbricatus (Basidiomycota)

2013

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The aim of the study was chemical analysis of polysaccharide fractions from sporocarps of Sarcodon imbricatus collected in natural sites and from the mycelium of in vitro cultures. Three polysaccharide fractions (FOI, FOII, FOIII) were isolated from sporocarps and two (FKI, FKII) from in vitro cultures. Qualitative analysis by HPLC method showed that they are composed of galactose and fucose (FOI, FKI) or glucose and fucose (FOII, FKII). FOIII fraction of the sporocarps consisted of glucose only. Molecular weights of isolated fractions ranged from 3.8 to 16.3 kDa for fractions from the sporocarps and from 5.8 to 14.7 kDa for that ones isolated from in vitro culture. The total percentage of sugar content for all fractions ranged from 97.8% to 99.1%. The percentage of uronic acids contents in acidic fractions was 2.6% and 2.7% for the FOI and FKI respectively. The work included also an assessment of cytotoxic activity of polysaccharide fractions in relation to tumor cell lines of human breast cancer MCV-7. FOI polysaccharide fraction of the sporocarps inhibited the growth of cancer cells in 50% compared to the control at a concentration of 0.0125%, while the polysaccharide fraction FKI from in vitro cultures inhibited cell growth in a concentration of 0.016%.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chemical composition and cytotoxic activity of the polysaccharide fractions in Sarcodon imbricatus (Basidiomycota)

2013

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Antitumor and Immunomodulatory Activities of Mushroom Polysaccharides

Ooi

2008

Mushrooms as Functional Foods

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Antiinflammatory and vasoprotective activities of polysaccharides isolated from fruit bodies of higher Fungi P.1. polysaccharides from Trametes gibbosa (Pers.: Fr)Fr. (Polyporaceae)

Czarnecki

Grzybek

1995

Phytotherapy Research

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Polysaccharide fractions TG-1 and TG-2 were isolated from the fruit bodies of Trarnetes gibbosa (Pers.: Fr.) Fr.(Polyporaceae). Both fractions are glucans with trace amounts of other sugars. The polysaccharide fractions administered to rats intravenously, strongly inhibited vessel permeability in the rat pleural exudate model, induced by carragenan, but did not influence its density. Both polysaccharide fractions decreased considerably the total protein level in the pleural effusion. Fractions TG-1 and TG-2 antagonized effectively the inflammation mediator complex induced by carragenan and they neutralized the pharmacological effects with respect to small vessel permeability. At the same time they increased the number of neutrophils and eosinophils and decreased the number of lymphocytes in the peripheral blood. The pharmacological activity of polysaccharide fractions TG-1 and TG-2 confirms their function as potential factors responsible for the stabilization of a wall vessel, especially in pathological conditions leading to endothelial damage.

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Biologically Active Polysaccharides fromTylopilus felleus

Abstract: Aromatase is a cytochrome P-450 enzyme responsible for the conversion of the androgens, androstenedione, and testosterone, to the corresponding estrogens, estrone, and estradiol, respectively. Several flavanoids have been shown to be inhibitors of aromatase (1), and we and others have de-

Cited by 3 publications

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Chemical composition and cytotoxic activity of the polysaccharide fractions in Sarcodon imbricatus (Basidiomycota)

Chemical composition and cytotoxic activity of the polysaccharide fractions in Sarcodon imbricatus (Basidiomycota)

Antitumor and Immunomodulatory Activities of Mushroom Polysaccharides

Antiinflammatory and vasoprotective activities of polysaccharides isolated from fruit bodies of higher Fungi P.1. polysaccharides from Trametes gibbosa (Pers.: Fr)Fr. (Polyporaceae)

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