Antiinflammatory and vasoprotective activities of polysaccharides isolated from fruit bodies of higher Fungi P.1. polysaccharides from Trametes gibbosa (Pers.: Fr)Fr. (Polyporaceae)

Abstract

Polysaccharide fractions TG-1 and TG-2 were isolated from the fruit bodies of Trarnetes gibbosa (Pers.: Fr.) Fr.(Polyporaceae). Both fractions are glucans with trace amounts of other sugars. The polysaccharide fractions administered to rats intravenously, strongly inhibited vessel permeability in the rat pleural exudate model, induced by carragenan, but did not influence its density. Both polysaccharide fractions decreased considerably the total protein level in the pleural effusion. Fractions TG-1 and TG-2 antagonized effectively the inflammation mediator complex induced by carragenan and they neutralized the pharmacological effects with respect to small vessel permeability. At the same time they increased the number of neutrophils and eosinophils and decreased the number of lymphocytes in the peripheral blood. The pharmacological activity of polysaccharide fractions TG-1 and TG-2 confirms their function as potential factors responsible for the stabilization of a wall vessel, especially in pathological conditions leading to endothelial damage.

In vitroimmunomodulatory activity, cytotoxicity and chemistry of some central European polypores

“…The ethanol extract analysis of this species revealed an average level of b-glucans (42.7 mg/g) and an average content of total polyphenols of 133 lmol GAE/g of extract. Literature suggests that injection of the polysaccharide fraction of this mushroom reduced carrageenan-induced inflammation and vessel permeability, while increasing the number of neutrophils and eosinophils and decreasing the number of lymphocytes in the blood (Czarnecki & Grzybek 1995).…”

Immunomodulatory activity of polysaccharide from Trametes gibbosa (Pers.) Fr (Basidiomycota, Fungi) mediated by TLR4 signaling pathway

“…It has been reported that the polysaccharide fraction from T. gibbosa fruit body possess several pharmacological activities such as antioxidant, anti-inflammatory,[ 12 13 ] genoprotective, antineurodegenerative, antiviral (against type A influenza), hypoglycemic, and hypolipidemic[ 11 ] properties. Also, the alcoholic extract from this mushroom can significantly induces the immune system cells activity.…”

Structural Characterization of a Novel Glucan from Achatina fulica and Its Antioxidant Activity

“…In recent years, some bioactive polysaccharides isolated from natural sources have attracted much more attention due to their various biological activities affected by different chemical structures . Glucans, a type of neutral polysaccharides, also has attracted increasing interest because of their pharmacological activities such as antitumor, immunomodulation, and antioxidation properties. − Liu et al reported on a water-soluble α-glucan from Strongylocentrotus nudus eggs with significant antitumor activity that was composed of a main chain of (1→4)-linked d -glucopyranosyl with branching points at O-6 of (1→6)-linked d -glucopyranosyl residues . Also, glucans from Bullacta exarata were reported to show antioxidant and antitumor activities. , Several studies have shown that the bioactivities of glucans are highly dependent on their structural characteristics.…”