Biological activities of synthesized silver nanoparticles from Cardiospermum halicacabum L.

Sundararajan, B.; Mahendran, G.; Thamaraiselvi, R; Kumari, B. D. Ranjitha

doi:10.1007/s12034-016-1174-2

Cited by 46 publications

(19 citation statements)

References 35 publications

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“…Coating of the AgNPs with 5 and 10 mM of the anionic surfactant SDS increased the negative charge significantly (P,0.05) to -25.3 and -28.2 mV, respectively. Sundararajan et al 54 have reported that particles that possess zeta-potential values .+30 and ,-30 mV are relatively stable. In the current study, AgNPs were stabilized by both electrostatic and steric repulsions.…”

Section: ±15mentioning

confidence: 99%

In vitro and in vivo evaluation of biologically synthesized silver nanoparticles for topical applications: effect of surface coating and loading into hydrogels

Mekkawy

El‐Mokhtar²,

Nafady

et al. 2017

IJN

152

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In the present study, silver nanoparticles (AgNPs) were synthesized via biological reduction of silver nitrate using extract of the fungus Fusarium verticillioides (green chemistry principle). The synthesized nanoparticles were spherical and homogenous in size. AgNPs were coated with polyethylene glycol (PEG) 6000, sodium dodecyl sulfate (SDS), and β-cyclodextrin (β-CD). The averaged diameters of AgNPs were 19.2±3.6, 13±4, 14±4.4, and 15.7±4.8 nm, for PEG-, SDS-, and β-CD-coated and uncoated AgNPs, respectively. PEG-coated AgNPs showed greater stability as indicated by a decreased sedimentation rate of particles in their water dispersions. The antibacterial activities of different AgNPs dispersions were investigated against Gram-positive bacteria (methicillin-sensitive and methicillin-resistant Staphylococcus aureus ) and Gram-negative bacteria ( Escherichia coli ) by determination of the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs). MIC and MBC values were in the range of 0.93–7.5 and 3.75–15 µg/mL, respectively, which were superior to the reported values in literature. AgNPs-loaded hydrogels were prepared from the coated-AgNPs dispersions using several gelling agents (sodium carboxymethyl cellulose [Na CMC], sodium alginate, hydroxypropylmethyl cellulose, Pluronic F-127, and chitosan). The prepared formulations were evaluated for their viscosity, spreadability, in vitro drug release, and antibacterial activity, and the combined effect of the type of surface coating and the polymers utilized to form the gel was studied. The in vivo wound-healing activity and antibacterial efficacy of Na CMC hydrogel loaded with PEG-coated AgNPs in comparison to the commercially available silver sulfadiazine cream (Dermazin ® ) were evaluated. Superior antibacterial activity and wound-healing capability, with normal skin appearance and hair growth, were demonstrated for the hydrogel formulations, as compared to the silver sulfadiazine cream. Histological examination of the treated skin was performed using light microscopy, whereas the location of AgNPs in the skin epidermal layers was visualized using transmission electron microscopy.

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Section: ±15mentioning

confidence: 99%

In vitro and in vivo evaluation of biologically synthesized silver nanoparticles for topical applications: effect of surface coating and loading into hydrogels

Mekkawy

El‐Mokhtar²,

Nafady

et al. 2017

IJN

152

View full text Add to dashboard Cite

show abstract

“…Several explanations for the toxic activity of the silver nanoparticles were known. They can penetrate through the cell wall and cause structural changes by interacting with sulphur and phosphorous containing biomolecules [36]. Another studies involving EPR spectra suggested that the generation of free radicals by the nanoparticles when it contact with the bacteria was responsible for the damage of cell membranes [37,38].…”

Section: Antimicrobial Efficacy Evaluationmentioning

confidence: 99%

Microwave assisted green synthesis of silver nanoparticles using leaf extract of elephantopus scaber and its environmental and biological applications

Francis

Joseph²,

Koshy

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

152

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The fabrication of spherical silver nanoparticles using the phytoreducing agent Elephantopus scaber is reported here. Irradiation of the reaction mixture under a domestic microwave oven enabled the formation of stable silver nanoparticles and was confirmed by UV-vis spectral portrait. Chemical components inherent in the aqueous leaf extract which reduces the monovalent silver were identified by FT-IR spectroscopy. The crystal structure of the synthesized nanoparticles was established as face centred cube by the powder XRD analysis. The TEM images suggest an average particle size of 37.86 nm to the silver nanoparticles. The prepared silver nanocatalysts can successfully reduce various organic nitro compounds, namely, 4-nitrophenol, 2-nitroaniline and 4-nitroaniline. The environmental pollution caused by dyes like eosin Y is effectively wiped off within a short span of time using the prepared nanocatalysts. The free radical quenching efficacy of the plant extract and the silver nanoparticles were checked by employing DPPH assay bestowing ascorbic acid reference. The potential of the nanoparticles as antimicrobials against six human disease causing pathogens were tested through the well diffusion pathway. The newly developed silver nanoparticles produced IC value 15.68 ± 0.15 μg/mL on human skin carcinoma cells, A375 and 65.49 ± 0.40 μg/mL on fibroblast cells, L929 when the cytotoxicity is studied employing MTT assay. Elephantopus scaber showed IC value 50.55 ± 0.17 μg/mL against A375 cells.

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“…We have got similar functional groups through FTIR analysis in some previous studies for the confirmation of AGNPs and ZnONPs, respectively [25,33]. On the other hand, in a recent study, they have observed DPPH scavenging activity of synthesized silver nanoparticles extracted from leaf samples and they have found highest activity as 4.30 µg/ml [34]. Similarly, in Lingaraju et al [35], synthesized ZnO nanoparticles showed good scavenging activity with inhibitory concentration (IC 50 ) value of 9.34 mg/ml.…”

Section: Discussionmentioning

confidence: 72%

Green Synthesis and Characterization of Marine Yeast-Mediated Silver and Zinc Oxide Nanoparticles and Assessment of Their Antioxidant Activity

Aswathy

Gabylis

et al. 2017

Asian J Pharm Clin Res

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Objective: The present study focuses on the synthesis of silver and zinc oxide (ZnO) nanoparticles from marine yeasts, isolated from the sediments of the Bay of Bengal, Bakkhali coast, West Bengal, and India. Methods:The marine sediment samples were diluted through serial diution and cultured onto yeast malt agar medium by the spread plate method. The selected yeast isolates were screened for the biosynthesis of silver and ZnO nanoparticles. Characterization of both the nanoparticles was done by applying ultraviolet (UV)-visible spectroscopy, atomic force microscopy, scanning electron microscopy, and Fourier transform infrared spectroscopy.Results: A total of five marine yeasts isolates were able to synthesize silver and ZnO nanoparticles as evidence of the color change. Optical density was measured in UV-spectrometer at different time interval for the conformation of production of nanoparticles. The size of silver nanoparticle was 31.78 nm and ZnO nanoparticle was 86.27 nm. The synthesized nanoparticles are then used for antioxidant assays. Conclusions:We are concluding that marine yeast isolates SAG1 and SAG2 both are potential marine yeast isolates which can synthesize both the silver and ZnO nanoparticles. They also showed good antioxidant activity.

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Biological activities of synthesized silver nanoparticles from Cardiospermum halicacabum L.

Cited by 46 publications

References 35 publications

In vitro and in vivo evaluation of biologically synthesized silver nanoparticles for topical applications: effect of surface coating and loading into hydrogels

In vitro and in vivo evaluation of biologically synthesized silver nanoparticles for topical applications: effect of surface coating and loading into hydrogels

Microwave assisted green synthesis of silver nanoparticles using leaf extract of elephantopus scaber and its environmental and biological applications

Green Synthesis and Characterization of Marine Yeast-Mediated Silver and Zinc Oxide Nanoparticles and Assessment of Their Antioxidant Activity

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