Among patients with unstable angina or myocardial infarction without ST-segment elevation, prasugrel did not significantly reduce the frequency of the primary end point, as compared with clopidogrel, and similar risks of bleeding were observed. (Funded by Eli Lilly and Daiichi Sankyo; TRILOGY ACS ClinicalTrials.gov number, NCT00699998.).

No abstract

This study reports the synthesis of noble metal nanoparticles, namely silver and gold from their respective salt by leaf extract of a medicinal plant Indigofera tinctoria. This leaf extract plays a dual role as stabilizing and reducing agent for the formation of nanoparticles. The synthesized silver and gold nanoparticles were characterized by UV-vis. spectroscopy, FTIR spectroscopy, XRD, TEM, EDX and AFM analysis. All these techniques confirm the formation of crystalline nanoparticles. The cytotoxic effect of I. tinctoria leaf extract and the nanoparticles were studied on lung cancer cell line A549. It was shown that the cell viability decreases with increasing concentration and nanoparticles has more toxic effect on cancer cell than the pure leaf extract. IC value of I. tinctoria leaf extract, AuNP and AgNP respectively, are 71.92 ± 0.76 μg/ml, 59.33 ± 0.57 μg/ml and 56.62 ± 0.86 μg/ml. Antimicrobial activities were tested against both bacterial and fungal strains by agar well diffusion method. The synthesized nanoparticles show high antimicrobial activities towards all tested microbial strains with varying degree. The antioxidant activities of synthesized nanoparticles were analysed by using DPPH method and found that nanoparticles show higher antioxidant activities than the leaf extract. Outstanding catalytic activities of nanoparticles were demonstrated by employing the reduction reactions of o/p-niroanilines by NaBH.

No abstract

The fabrication of spherical silver nanoparticles using the phytoreducing agent Elephantopus scaber is reported here. Irradiation of the reaction mixture under a domestic microwave oven enabled the formation of stable silver nanoparticles and was confirmed by UV-vis spectral portrait. Chemical components inherent in the aqueous leaf extract which reduces the monovalent silver were identified by FT-IR spectroscopy. The crystal structure of the synthesized nanoparticles was established as face centred cube by the powder XRD analysis. The TEM images suggest an average particle size of 37.86 nm to the silver nanoparticles. The prepared silver nanocatalysts can successfully reduce various organic nitro compounds, namely, 4-nitrophenol, 2-nitroaniline and 4-nitroaniline. The environmental pollution caused by dyes like eosin Y is effectively wiped off within a short span of time using the prepared nanocatalysts. The free radical quenching efficacy of the plant extract and the silver nanoparticles were checked by employing DPPH assay bestowing ascorbic acid reference. The potential of the nanoparticles as antimicrobials against six human disease causing pathogens were tested through the well diffusion pathway. The newly developed silver nanoparticles produced IC value 15.68 ± 0.15 μg/mL on human skin carcinoma cells, A375 and 65.49 ± 0.40 μg/mL on fibroblast cells, L929 when the cytotoxicity is studied employing MTT assay. Elephantopus scaber showed IC value 50.55 ± 0.17 μg/mL against A375 cells.