Biochemical marker indices of negative impacts in children under the exposure to the chlororganic compounds with drinking water

Землянова, М. А.; Pustovalova, Olga; Mazunina, D. L.; Sboev, A. S.

doi:10.18821/0016-9900-2016-95-1-97-101

Cited by 3 publications

(1 citation statement)

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“…Из-за сложного химического состава смесей ППД и множественных путей поступления оценка фактического воздействия тригалометанов на организм человека является очень сложной задачей. Повышение точности и объективности количественной оценки рисков здоровью населения идет в том числе по пути применения данных о внутренней экспозиции -содержании загрязнителей (их метаболитов) во внутренних средах организма вещества [13][14][15][16] 2010) подтвердило гипотезу о связи рака мочевого пузыря у человека с генетическим полиморфизмом GSTM1, GSTZ1 [28]. В ряде статей приводятся доказательства задержки роста плода при наличии у матерей генетических полиморфизмов генов: CYP2E1, MTHFR [29], CYP2E1 и GSTZ1 [30], CYP2E1 [31].…”

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Polymorphisms of xenobiotic metabolism enzyme genes cyp2e1, gstm1, gstt1, ephx1 as biomarkers of sensitivity to exposure to water disinfection byproducts (using chloroform as an example)

Drazdova,

Kaliasniova,

Syakhovich

et al. 2023

Health Risk Analysis

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Chloroform accumulation in the body and the increase in its steady-state concentrations in blood of exposed people have been established to be associated with polymorphisms of enzyme genes in a genotype involved in metabolism of water disinfection byproducts (A415G of EPHX1 gene, C1091T of CYP2E1 gene, zero mutations of GSTT1 and GSTM1 genes) (р < 0.000001). These polymorphisms in a genotype correlate with higher chloroform levels in blood of people consuming chlorinated drinking water: by 43.8 % and higher for GSTM1 gene polymorphism; by 68.2 % and higher for GSTT1; by 80.4 % and higher for EPHX1 (р < 0.01). EPHX1 genetic polymorphism makes chloroform accumulation much more probable (levels in blood ≥ Р75), which is the most pronounced when combined with GSTТ1 genetic polymorphism. The study results allow us to consider hetero- and homozygous polymorphic genotypes AG/GG for the EPHX1 gene, CT/TT for the CYP2E1 gene, and the null allele in the GSTT1 and GSTM1 genes as genetic predisposition factors for chloroform accumulation in the body. This increases the probability of health outcomes associated with chronic exposure to this disinfection byproduct. The A415G polymorphism of the EPHX1 gene and null alleles of GSTT1 gene, their combinations including the combination with the null allele of the GSTM1 gene and/or the C1091T polymorphism of the CYP2E1 gene can be used as the most informative biomarkers of sensitivity when assessing risks associated with exposure to trihalomethanes (chloroform) at levels not exceeding MPC in water.

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Polymorphisms of xenobiotic metabolism enzyme genes cyp2e1, gstm1, gstt1, ephx1 as biomarkers of sensitivity to exposure to water disinfection byproducts (using chloroform as an example)

Drazdova,

Kaliasniova,

Syakhovich

et al. 2023

Health Risk Analysis

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Hygenic Assessment of Dynamics of Chloroform Exposition in Perm Region and It's Impact on Causing Diseases of the Blood, Blood-Forming Organs and Certain Disorders Involving Immune Mechanism Among Children

Chetverkina

Kleyn

Chigvintsev

2018

HAS

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On the basis of the system review, the relevance of the problem of the chloroform content in the drinking water of centralized drinking-water supply systems in the Perm Territory is confirmed. The comparative characteristic with the average Russian indices is presented. Insufficient volume of information containing data on the impact of the oral intake of chloroform on the blood system was established. There are presented results of the research content of chloroform in water samples from centralized drinking water supply in the cities of Perm region, as well as in the blood of the child population aged from 3 to 13 years living in these areas and consuming water under investigation in the period from 2011 to 2015. A long-term dynamics of the content of chloroform, contained in samples of drinking water and in bio-environments is described. A mathematical simulation of the dependence of the chloroform content in the blood as an exposure marker on the concentration of chloroform in water was carried out. As a result of the analysis of the prevalence rate of diseases of the blood system, hematopoietic organs and certain disorders involving the immune mechanism in the child population, there was established the relevance of differences between the territories of Permsky Krai with surface and underground water supply. The dynamics of the chloroform content in water and morbidity according to the class of blood diseases, hematopoietic organs and certain disorders involving the immune mechanism is presented and described. The association between the exposure to the oral intake of chloroform with drinking water with a morbidity on the class of diseases of the blood system was established on the basis of constructing a mathematical model. The conclusion about the legitimacy of information on the effect of the oral intake of chloroform on the blood system, hematopoietic organs and certain disorders involving the immune mechanism is presented.

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Establishing the Association between Blood Levels of Chloroform in Children and Concentrations of Chloroform and Its Derivatives in Drinking Water of Centralized Water Supply Systems

Ts¹,

Tv²,

Mal'Tseva³

et al. 2020

PH&LE

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Background: Surface reservoirs remain one of the priority sources of drinking water in the Russian Federation whereas the increasing anthropogenic effect on the environment does not exclude the possibility of contamination of surface waters with toxic compounds. The use of traditional methods of water disinfection with active chlorine aggravates the situation and leads to formation of highly toxic organochlorine compounds. In this regard, one of the urgent hygienic problems is to establish health effect of these toxicants in the population including its most sensitive groups. The objective of the study was to establish and quantify the relationship between concentrations of chloroform and its derivatives in drinking water and blood levels of organochlorine compounds in children consuming potable water with a higher content of chlorine and its derivatives. Materials and methods: The study was conducted on six territories of the Perm Region constituting an observation area where drinking water was noncompliant with hygienic standards by a number of indices, and a comparison area. The analysis of trihalomethanes in drinking water samples was carried out in accordance with the requirements of sanitary regulations SanPiN 2.1.4.1074–01. The levels of trihalomethanes (chloroform, carbon tetrachloride, dibromochloromethane, dichlorobromethane, and 1,2-dichloroethane) in children’s blood samples were analyzed by capillary gas chromatography in combination with a specific detector to increase selectivity and sensitivity of determination. We used a Kristall-5000 gas chromatograph with an Optima-5 capillary column (25 m × 0.32 mm × 0.5 μL) and a selective electron capture detector (ECD). Results: The data of comprehensive chemical analyses of average levels of trihalomethanes in blood samples of children consuming drinking water with an increased content of determined compounds (up to 3.5 MPC) and the water complying with hygienic standards are presented. We observed significant differences (р<0.005) between two groups in the blood levels of chloroform, carbon tetrachloride, and 1,2-dichloroethane that were 5.6, 6 and 24 times higher in children of the test group compared to the controls. Conclusion: We revealed a statistically significant causal relationship between the increase in chloroform concentrations in drinking water and the increase in blood levels of chloroform in children described by the equation у=0.00188+0.01782х (R2=0.263, p=0.0018).

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Biochemical marker indices of negative impacts in children under the exposure to the chlororganic compounds with drinking water

Cited by 3 publications

References 1 publication

Polymorphisms of xenobiotic metabolism enzyme genes cyp2e1, gstm1, gstt1, ephx1 as biomarkers of sensitivity to exposure to water disinfection byproducts (using chloroform as an example)

Polymorphisms of xenobiotic metabolism enzyme genes cyp2e1, gstm1, gstt1, ephx1 as biomarkers of sensitivity to exposure to water disinfection byproducts (using chloroform as an example)

Hygenic Assessment of Dynamics of Chloroform Exposition in Perm Region and It's Impact on Causing Diseases of the Blood, Blood-Forming Organs and Certain Disorders Involving Immune Mechanism Among Children

Establishing the Association between Blood Levels of Chloroform in Children and Concentrations of Chloroform and Its Derivatives in Drinking Water of Centralized Water Supply Systems

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