Hygenic Assessment of Dynamics of Chloroform Exposition in Perm Region and It's Impact on Causing Diseases of the Blood, Blood-Forming Organs and Certain Disorders Involving Immune Mechanism Among Children

Abstract

On the basis of the system review, the relevance of the problem of the chloroform content in the drinking water of centralized drinking-water supply systems in the Perm Territory is confirmed. The comparative characteristic with the average Russian indices is presented. Insufficient volume of information containing data on the impact of the oral intake of chloroform on the blood system was established. There are presented results of the research content of chloroform in water samples from centralized drinking water supply in the cities of Perm region, as well as in the blood of the child population aged from 3 to 13 years living in these areas and consuming water under investigation in the period from 2011 to 2015. A long-term dynamics of the content of chloroform, contained in samples of drinking water and in bio-environments is described. A mathematical simulation of the dependence of the chloroform content in the blood as an exposure marker on the concentration of chloroform in water was carried out. As a result of the analysis of the prevalence rate of diseases of the blood system, hematopoietic organs and certain disorders involving the immune mechanism in the child population, there was established the relevance of differences between the territories of Permsky Krai with surface and underground water supply. The dynamics of the chloroform content in water and morbidity according to the class of blood diseases, hematopoietic organs and certain disorders involving the immune mechanism is presented and described. The association between the exposure to the oral intake of chloroform with drinking water with a morbidity on the class of diseases of the blood system was established on the basis of constructing a mathematical model. The conclusion about the legitimacy of information on the effect of the oral intake of chloroform on the blood system, hematopoietic organs and certain disorders involving the immune mechanism is presented.

Drinking water quality: health risk factors and efficiency of control and surveillance activities by Rospotrebnadzor

“…В 2018 г. в Российской Федерации с загрязнением питьевой воды химическими веществами (хлор и хлорорганические соединения, аммиак, железо, марганец, мышьяк, никель, медь, бор, магний и др.) и микробиологическими агентами было ассоциировано около 16,1 тысячи случаев смерти (по причине болезней системы кровообращения, органов пищеварения, злокачественных новообразований, некоторых инфекционных и паразитарных заболеваний) и 1764,49 тысячи случаев заболеваний органов пи-щеварения, мочеполовой системы, костно-мышечной системы и соединительной ткани, системы кровообращения, кожи и подкожной клетчатки, эндокринной системы и других болезней [1][2][3][4][5].…”

“…Ответственность за осуществление контроля качества питьевой воды и соблюдение санитарноэпидемиологического благополучия населения Российской Федерации возложена на органы и учреждения Роспотребнадзора, а также другие органы государственной власти и организации, которые выполняют эти функции в рамках государственного санитарно-эпидемиологического надзора 5 , социально-гигиенического мониторинга 6,7 и производственного контроля 8 .…”

Drinking water quality: health risk factors and efficiency of control and surveillance activities by Rospotrebnadzor

“…In 2018 in the RF approximately 16.1 thousand death cases (due to circulatory system diseases, digestive organs diseases, malignant neoplasms, certain infectious and parasitic diseases) and 1,764.49 thousand diseases in the digestive organs, urogenital system, musculoskeletal system and conjunctive tissue, circulatory system, skin and subcutaneous tissue, endocrine system and some other diseases were caused by drinking water that was contaminated with various chemicals (chlorine and chlorinated organic compounds, ammonia, iron, manganese, arsenic, nickel, copper, boron, magnesium, etc.) and microbe agents [1][2][3][4][5].…”

“…Rospotrebnadzor's organs and institutions bear the full responsibility for control over drinking water quality and providing sanitary-epidemiologic welfare of the population in the RF; there are also some other state authorities that perform these functions within state sanitary-epidemiologic surveillance 5 , social-hygienic monitoring 6,7 , and industrial control 8 .…”