2011
DOI: 10.1590/s1516-05722011000100003
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Abstract: RESUMO:Coriandrum sativum L. (Umbelliferae), conhecido popularmente por coentro, é uma planta doméstica cultivada nas diversas partes do mundo, inclusive no Brasil. As folhas e frutos do coentro são utilizados como condimento em culinária e na medicina popular como analgésica, antirreumática, carminativa e colagoga. O objetivo deste estudo foi avaliar o efeito do tratamento com o óleo essencial (OEC) e o extrato hidroalcóolico (EHC) do coentro em modelos experimentais de inflamação em roedores. A atividade ant… Show more

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Cited by 10 publications
(10 citation statements)
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References 30 publications
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“…As expected, animals from control group and treated with placebo showed significant changes in the tissue morphology when compared with naive mice (Figures 4B and C). The connective tissue in the dermis presented lower amount of extracellular matrix due to the increase in cell number that migrated to the injured site, which was approximately 4 folds greater than the naive mice, corroborating with the data obtained in MPO assay (Zanusso-Junior et al, 2011). No significant difference was found in the number and morphology of sebaceous glands, hair follicles and blood vessels, when compared to the naive group ( Figure 4A).…”
Section: Resultssupporting
confidence: 88%
“…As expected, animals from control group and treated with placebo showed significant changes in the tissue morphology when compared with naive mice (Figures 4B and C). The connective tissue in the dermis presented lower amount of extracellular matrix due to the increase in cell number that migrated to the injured site, which was approximately 4 folds greater than the naive mice, corroborating with the data obtained in MPO assay (Zanusso-Junior et al, 2011). No significant difference was found in the number and morphology of sebaceous glands, hair follicles and blood vessels, when compared to the naive group ( Figure 4A).…”
Section: Resultssupporting
confidence: 88%
“…Then after being injected all four hours later, the mice were sacrificed and their thickness measured (mm) and considered to assess the edema mass (mg). In both methods, the thickness values for the right ear were discounted from the right ear against all groups and the comparison to control was negative [51].…”
Section: G In Vivo Studymentioning
confidence: 99%
“…Then, ear circles of 6 mm were cut out and weighed on an analytical balance, to assess the intensity of mass edema (mg). In both methods, thickness and weight values for the right ears were discounted from the opposite side ears in all groups, and converted to a percentage, relative to the negative control [10,11].…”
Section: Ratiomentioning
confidence: 99%
“…The main compound present in the croton oil (Croton tiglium) that acts as an inflammatory agent is 12-O-tetradecanoylphorbol-13-acetate (TPA). The application of the oil results in rapid accumulation of inflammatory cells, such as neutrophils and macrophages, to produce reactive oxygen species at the site [11].…”
Section: Anti-inflammatory Activity Evaluation By Edema Ear Rats Indumentioning
confidence: 99%