Topical anti-inflammatory activity of semisolid containing standardized Aleurites moluccana L. Willd (Euphorbiaceae) leaves extract

Hoepers, Silmara Mendes; Souza, Hugo Guilherme Martins Tolentino de; Quintão, Nara Lins Meira; Santin, José Roberto; Filho, Valdir Cechinel; Silva, Ruth Meri Lucinda; Couto, Angélica Garcia; Silva, Kathryn Ana Bortolini Simão da

doi:10.1016/j.jep.2015.07.024

Cited by 15 publications

(9 citation statements)

References 32 publications

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“…Among these, the applications of plant based nanotechnology plays a significant role in the process of wound healing [16,17]. The plant based materials have proved at all times to be a powerful remedy for health care [18][19][20][21][22][23][24][25][26][27]. Accordingly, the grape seed extract containing PCs have been investigated for wound treatment and in the management of many illnesses such as cancers, cardiovascular disease, gastric ulcers, obesity and skin inflammations.…”

Section: Introductionmentioning

confidence: 99%

Nano formulated proanthocyanidins as an effective wound healing component

Ramesh

Volova

Oluwafemi

et al. 2020

Materials Science and Engineering: C

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Proanthocyanidins (PCs), a component of grape seed extract (GSE), has recently being used for the treatment of wounds. However, poor absorption, poor stability and rapid elimination from the systemic circulation limit its acceptance. In addressing these problems, we herein report the development of PCs based nanoformulations (PCs/SOLU) for the first time based on 1 % GSE and assessed its wound healing potential in-vivo on the wistar rats. GSE and PCs/SOLU nanodispersions 1 % were prepared by incorporating them into the ointment base via uniform mixing to form ointment which could be easily applied topically to wounds. The antibacterial activity of PCs/SOLU against gram positive and gram-negative bacteria strains proved that the cell membranes became more permeable with disrupted cell structure. While carrageenan and histamine induced rat paw edema analyses show there was no inflammatory signs in animals treated with 1 wt% of PCs/SOLU nanodispersion. Excision wound measuring about 3 cm in depth was created on the wistar rats. The ointment was applied topically on the wounded site and the wound contraction was measured daily. Grape seed extract (GSE) ointment, ointment base and povidone-iodine (Povi-Iod) ointment of about 1 % was used as the control, positive and negative standards. PCs/SOLU nanodispersion heals the wound by mobilising the fibroblasts in the wound site and inhibits the inflammatory response through decreased expression of monocyte. The macroscopical, immunological and histopathological assessments revealed that PCs/SOLU nanodispersion ointment usage improves the cell adhesion and proliferation

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Section: Introductionmentioning

confidence: 99%

Nano formulated proanthocyanidins as an effective wound healing component

Ramesh

Volova

Oluwafemi

et al. 2020

Materials Science and Engineering: C

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“…Anti-quorum-sensing activity has been reported from the leaf extracts against Chromobacterium violaceum (Guzman and Padilla 2017). Dried leaf extracts are anti-inflammatory, analgesic, and heal wounds in mice (Cesca et al 2012;Hoepers et al 2015;Niazi et al 2010). Antinociceptive activities are attributed to the flavonoid contents of the leaves (Quintão et al 2011).…”

Section: Phytochemistrymentioning

confidence: 99%

Aleurites moluccana (L.) Willd. Euphorbiaceae

Mustaqim¹,

Raihandhany

2020

Ethnobotany of Mountain Regions

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“…The genus Aleurites is subdivided into Aleurites montana, Aleurites trisperma, Aleurites cordata, Aleurites fordii and Aleurites moluccana . The leafs of the plant Aleurites moluccana (AM) has been used to treat gastritis, fever, pain, diarrhea, asthma, and inflammation [ 4 , 5 ] showing antibacterial [ 6 ] and antiviral effects [ 7 ]. AM’s bark dichloromethane extract contains acetyl aleuritolic acid, atraric acid, spruceanol, (5β,10α)-12-hydroxy-13-methoxy-8,11,13-podocarpatrien-3-one and sonderianol [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats

Rosa

Ribeiro

Silva

et al. 2022

Diabetol Metab Syndr

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Background Candlenut (CN) has been used indiscriminately for weight loss. In vivo effects of CN in different doses are scarce. Objective To evaluate the effects of CN ingestion in obese rats. Design Thirty animals (obese and non-obese) received one of three different types of treatments: placebo, CN ingestion in a popular therapeutic regimen (8 days with oral administration of 0.2 mg/kg followed by 20 days with doses of 0.4 mg/kg), and ingestion of a doubled popular dose—called 2CN. Treatment was maintained for 28 days. Results The fatty acid profile of CN indicated mainly linolelaidic and palmitoleic acids. Rats receiving CN and 2CN showed reduced plasmatic levels of glucose and lipoproteins (p < 0.05). A dose-dependent carcass fat reduction was observed (p < 0.05). Blood levels of aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) reduced with CN and increased with 2CN doses (p < 0.05). Alanine aminotransferase (ALT) and the atherogenic index remained similar among all treatments (p > 0.05). Hepatic vacuolation decreased with CN, but the 2CN dose produced mononuclear leucocyte infiltrate. Conclusions Although CN presented beneficial effects on the metabolism of rats, it also caused increased risk of liver damage.

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Topical anti-inflammatory activity of semisolid containing standardized Aleurites moluccana L. Willd (Euphorbiaceae) leaves extract

Cited by 15 publications

References 32 publications

Nano formulated proanthocyanidins as an effective wound healing component

Nano formulated proanthocyanidins as an effective wound healing component

Aleurites moluccana (L.) Willd. Euphorbiaceae

Fatty acids composition and in vivo biochemical effects of Aleurites moluccana seed (Candlenut) in obese wistar rats

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