Automated microanalysis of carbamazepine and its epoxide and trans-diol metabolites in plasma by column liquid chromatography

Rouan, Marie-Claude; Campestrini, Joelle; Clanche, V. Le; Lecaillon, J.B.; Godbillon, J.

doi:10.1016/0378-4347(92)80475-6

Cited by 21 publications

(3 citation statements)

References 6 publications

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“…Simultaneous determinations of CBZ and its metabolites in biological fluids and drug products (Burke and Thenot, 1985;Owen et al, 2001) have been published, including, solid-liquid extraction (Wad, 1984), liquid-liquid extraction (Rouan et al, 1992), column-switching (Juergens, 1984), deproteinization (Liu et al, 1993), spectrofluorimetry method (Huang et al, 2002), gas-liquid chromatography (Chen and Bashi, 1991), FT-Raman spectroscopy (Auer et al, 2003), planar chromatography (Mennickent et al, 2009), stir bar-sorptive extraction and high-performance liquid chromatography-UV detection (SBSE/HPLC-UV) (Queiroz et al, 2008) and high-performance thin layer chromatography (HPTLC) (Patel et al, 2011). Also, LC-mass spectrometry methods (Breton et al, 2005;Van Rooyen et al, 2002;Miao and Metcalfe, 2003;Zhu et al, 2005) have been reported for the detection of CBZ and its metabolites in aquatic environments and in plasma.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of an HPLC–UV method for the quantification of carbamazepine in rabbit plasma

Mowafy

Alanazi

Maghraby

2012

Saudi Pharmaceutical Journal

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An isocratic simple rapid assay has been developed and validated for the determination of carbamazepine (CBZ) in both solution form and rabbit plasma using propylparaben as an internal standard. The assay was performed using a μ-Bondapak C18 (150 mm × 4.6 mm i.d) with a mobile phase consisting of methanol and water (50:50), the flow rate was 1 ml/min and UV detection at 285 nm. The method was found to be specific for CBZ, no interfering peaks were observed with an overall analytical run time of 15 min. Accuracy reported as % recovery were found to be 98.37-100.45% and 97.53-103.58% for inter-day and intra-day accuracies, respectively. Inter-day precision (reproducibility) was found to be 0.53-2.75% RSD, while intra-day precision (repeatability) was found to be 1.06-3.7% RSD for the samples studied. The calibration curve was found to be linear with the equation y = 0.2847x + 0.0138, with a correlation coefficient of 0.9999 (R (2)) over a concentration range of 0.5-40 μg/ml. The limit of quantitation was the lowest concentration. The method is simple and rapid and does not require any preliminary treatment of the sample. The method was fully validated.

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Section: Introductionmentioning

confidence: 99%

Development and validation of an HPLC–UV method for the quantification of carbamazepine in rabbit plasma

Mowafy

Alanazi

Maghraby

2012

Saudi Pharmaceutical Journal

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“…A number of LC methods with UV detection for the determination of CBZ and its metabolite in drug products and human plasma have been described [15] , [16] , [17] . LC–MS methods have also been reported for the determination of CBZ [18] , [19] and its metabolites [20] , [21] in biological fluids.…”

Section: Lcmentioning

confidence: 99%

Quantitative bioanalytical and analytical method development of dibenzazepine derivative, carbamazepine: A review

Datar¹

2015

Journal of Pharmaceutical Analysis

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Bioanalytical methods are widely used for quantitative estimation of drugs and their metabolites in physiological matrices. These methods could be applied to studies in areas of human clinical pharmacology and toxicology. The major bioanalytical services are method development, method validation and sample analysis (method application). Various methods such as GC, LC–MS/MS, HPLC, HPTLC, micellar electrokinetic chromatography, and UFLC have been used in laboratories for the qualitative and quantitative analysis of carbamazepine in biological samples throughout all phases of clinical research and quality control. The article incorporates various reported methods developed to help analysts in choosing crucial parameters for new method development of carbamazepine and its derivatives and also enumerates metabolites, and impurities reported so far.

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“…The other strategy misuses the unordinary fluorescence of CBZ on a nylon layer (Escandar et al, 2004). Synchronous determinations of CBZ and its metabolites in natural liquids and medication items (Burke and Thenot, 1985;Owen et al, 2001) have been distributed, including, solid-liquid extraction (Wad, 1984), liquid-liquid extraction (Rouan et al, 1992), section exchanging (Juergens, 1984), deproteinization (Liu et al, 1993), spectrofluorimetry strategy (Huang et al, 2002) Along these lines, the point of this study was to build a strategy taking into account UPLC-UV that is fit for dissecting CBZ in both arrangement and blood tests keeping in mind the end goal to encourage transport investigations of CBZ.…”

Section: Introductionmentioning

confidence: 99%

UFLC Method Development for the Quantification of Carbamazepine in Blood Samples and an Application to Pharmacokinetic Study

dev¹,

Lā²,

Yamsani³

et al. 2015

IJIRSET

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An isocratic simple rapid method has been developed and validated for the determination of carbamazepine (CBZ) in both solution form and blood samples. The assay was performed using an analytical C18 (100 mm×4.6 mm i. d) with a mobile phase consisting of methanol and water (50:50), the flow rate was 1 ml/min and UV detection at 285 nm. The method was found to be specific for CBZ, no interfering peaks were observed with an overall analytical run time of 5 min. Accuracy reported as % recovery were found to be 95.83-103.34% and 93.18-104.49% for inter-day and intra-day accuracies, respectively. Inter-day precision (reproducibility) was found to be 0.22-1.19 SD, while intra-day precision (repeatability) was found to be 0.14-2.12 SD for the samples studied. The calibration curve was found to be linear with the equation y=13474x+16969, with a correlation coefficient of 0.997 (R2) over a concentration range of 0.5-40 lg/ml. The farthest point of quantitation was the least fixation. The system is straightforward and fast and does not require any preparatory treatment of the specimen. The strategy was approved and effectively requested the blood tests to study the medication pharmacokinetic parameters.

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Automated microanalysis of carbamazepine and its epoxide and trans-diol metabolites in plasma by column liquid chromatography

Cited by 21 publications

References 6 publications

Development and validation of an HPLC–UV method for the quantification of carbamazepine in rabbit plasma

Development and validation of an HPLC–UV method for the quantification of carbamazepine in rabbit plasma

Quantitative bioanalytical and analytical method development of dibenzazepine derivative, carbamazepine: A review

UFLC Method Development for the Quantification of Carbamazepine in Blood Samples and an Application to Pharmacokinetic Study

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