AuNPs-poly-DAN modified pyrolytic graphite sensor for the determination of Cefpodoxime Proxetil in biological fluids

Yadav, Saurabh; Agrawal, Bharati; Goyal, Rajendra N.

doi:10.1016/j.talanta.2013.02.044

Cited by 31 publications

(16 citation statements)

References 29 publications

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“…However, they present disadvantages such as passivation from the products of electrochemical reactions and surface blocking due to the possible presence of residues from polishing materials, which decrease the sensitivity and reproducibility of the analysis . External modifying agents can reduce the effect of these problems, such as carbon nanomaterials, polymers, metal nanoparticles and even biological components such as enzymes or proteins, deliberately immobilized in order to preset and control the physicochemical nature of the electrode/solution interface.…”

Section: Introductionmentioning

confidence: 99%

Electroanalysis of Cefadroxil Antibiotic at Carbon Nanotube/Gold Nanoparticle Modified Glassy Carbon Electrodes

2020

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The electrochemical characterization and determination of the antibiotic cefadroxil were carried out at multi-walled carbon nanotube (CNT) and gold nanoparticle (AuNP) modified glassy carbon electrodes (GCE). Oxidation of the phenol moiety of cefadroxil occurred at slightly less-positive potentials and with a higher current response than at bare GCE. Differential pulse voltammetry and electrochemical impedance spectroscopy showed that the architecture combining CNT and AuNP surface modification is the best in pH 7 buffer solution. Scanning electron microscopy demonstrated good coverage of the AuNPs on the CNTs. The fixed potential amperometric determination of cefadroxil was carried out at + 0.74 V vs Ag/AgCl with a limit of detection of 0.22 μM. Analysis of cefadroxil in commercial samples presented high recovery values and the amount of the pharmaceutical in each capsule was in excellent agreement with that measured by UV/Vis spectroscopy.

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Section: Introductionmentioning

confidence: 99%

Electroanalysis of Cefadroxil Antibiotic at Carbon Nanotube/Gold Nanoparticle Modified Glassy Carbon Electrodes

2020

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“…21 Aer polymerization, the sensor was rinsed with double distilled water in order to eliminate any adsorbed monomer of 1,5-DAN and was kept overnight at room temperature. The electrochemical polymerization of 1,5-DAN was achieved using cyclic voltammetry in 10 mM 1,5-DAN solution prepared in 1 M HClO 4 .…”

Section: Fabrication Of the Modied Sensormentioning

confidence: 99%

Glutaraldehyde sandwiched amino functionalized polymer based aptasensor for the determination and quantification of chloramphenicol

2015

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In the present work, the crosslinking property of glutaraldehyde (GA) is exploited to construct a 1,5-diaminonaphthalene (1,5-DAN) modified aptamer based sensor for the determination and quantification of chloramphenicol (CAP). The sensor was fabricated by electro-polymerizing 1,5-DAN on the edge plane pyrolytic graphite (EPPG) followed by immobilization of CAP selective aptamer on the amino functionalized polymer modified EPPG surface using GA, which resulted in covalent linkage with the -NH 2 groups of the aptamer as well as those present on the polymerized electrode surface.Resulting GA sandwiched aptasensor leads to a tremendous improvement in the stability and sensitivity of the sensor in comparison to one fabricated without crosslinking. Characterization of the modification protocol was done using scanning electron microscopy (SEM), quartz crystal microbalance (QCM) analysis, and electrochemical impedance spectroscopy (EIS). Under optimized parameters, CAP was detected in a linear working range of 50-500 fM with the detection limit and sensitivity of 11 fM (n ¼ 3, R.S.D ¼ 0.15%) and 0.023 mA fM À1 respectively. The practical utility of the developed aptasensor has also been demonstrated by analysing CAP in complex matrix like urine, commercially available pharmaceutical samples and the Rosetta cells supernatant. The observed results suggests that the present electrochemical aptasensor is suitable for the detection of CAP in medicines, diagnosis of chloramphenicol resistant bacteria and virus, as well as for checking its adulteration in food and other dietary supplements.

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“…p‐DAN is found to have versatile applications in the construction of chemically modified sensors due to its electroactive nature in both acidic and aqueous solutions and also bears free NH 2 groups as shown by FT‐IR analysis 34. The application of p‐DAN conducting polymer has been studied at different surfaces, such as platinum and glassy carbon, pyrolytic graphite electrode with gold nanoparticles and glassy carbon electrode with multiwalled carbon nanotube in the selective monitoring of compounds 35, 36. p‐DAN has been considered as a promising candidate to form polymerdrug conjugate for drug delivery purposes and it is successfully applied for the determination of various drugs as earlier reported by our group 37–39.…”

Section: Introductionmentioning

confidence: 99%

A Simple and Sensitive Poly‐1,5‐Diaminonaphthalene Modified Sensor for the Determination of Sulfamethoxazole in Biological Samples

Chasta

Goyal

2015

Electroanalysis

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Sulfamethoxazole (SMZ), an antibacterial sulfonamide drug, has been selectively determined using poly‐1,5‐diaminonaphthalene (p‐DAN) modified glassy carbon electrode (GCE). The modified sensor was characterized by field emission scanning electron microscopy (FE‐SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). SMZ showed linear response in the concentration range of 0.5–150 µM by using square wave voltammetry (SWV) and the detection limit was found to be 0.05 nM with sensitivity of 0.085 µA µM−1. The proposed sensor has been successfully employed to determine SMZ in the pharmaceutical tablets and human urine samples.

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AuNPs-poly-DAN modified pyrolytic graphite sensor for the determination of Cefpodoxime Proxetil in biological fluids

Cited by 31 publications

References 29 publications

Electroanalysis of Cefadroxil Antibiotic at Carbon Nanotube/Gold Nanoparticle Modified Glassy Carbon Electrodes

Electroanalysis of Cefadroxil Antibiotic at Carbon Nanotube/Gold Nanoparticle Modified Glassy Carbon Electrodes

Glutaraldehyde sandwiched amino functionalized polymer based aptasensor for the determination and quantification of chloramphenicol

A Simple and Sensitive Poly‐1,5‐Diaminonaphthalene Modified Sensor for the Determination of Sulfamethoxazole in Biological Samples

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