Electroanalysis of Cefadroxil Antibiotic at Carbon Nanotube/Gold Nanoparticle Modified Glassy Carbon Electrodes

Sanz, Caroline G.; Serrano, Sı́lvia Helena Pires; Brett, Christopher M.A.

doi:10.1002/celc.202000255

Cited by 13 publications

(15 citation statements)

References 66 publications

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“…39 On the basis of the computed kinetic parameters (n and α) and proton to electron ratio (1:1), a reaction mechanism was proposed (Scheme S3), which is consistent with the literature. 18,41 2.4. SWV Investigation of CLN and CFL at Poly(reso)/ GCE.…”

Section: Cyclic Voltammetric Investigation Of Cln and Cfl 231 Electro...mentioning

confidence: 99%

Potentiodynamic Poly(resorcinol)-Modified Glassy Carbon Electrode as a Voltammetric Sensor for Determining Cephalexin and Cefadroxil Simultaneously in Pharmaceutical Formulation and Biological Fluid Samples

et al. 2022

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This study covers the development of a fast, selective, sensitive, and stable method for the simultaneous determination of cephalosporins (cephalexin (CLN) and cefadroxil (CFL)) in biological fluids and tablet samples using potentiodynamic fabrication of a poly(resorcinol)-modified glassy carbon electrode (poly(reso)/GCE). The results of cyclic voltammetry and electrochemical impedance spectroscopy supported the modification of the GCE by a polymer layer that raised the electrode surface area and conductivity. At the poly(reso)/GCE, an irreversible oxidative peak with four- and fivefold current enhancement for CLN and CFL, respectively, at a substantially lower potential demonstrated the catalytic action of the modifier. Under optimized solution and parameters, the peak current response at the poly(reso)/GCE revealed a linear dependence on the concentration of CLN and CFL within the range 0.1–300 and 0.5–300 μM, respectively, with a limit of detection (LoD) of 3.12 and 8.7 nM, respectively. The levels of CLN in four selected tablet brands and CFL in two tablet brands were in the vicinity of 91.00–103.65% and 97.7–98.83%, respectively, of their nominal values. The recovery results for CLN in pharmaceutical samples were in the range of 99.00–100.67% and for CFL 97.9–99.75% and for blood serum and urine samples 99.55–100.55% and 99.33–100.34% for CLN and 97.13–100.60% and 96.73–102.50% for CFL, respectively. Interference recovery results with errors less than 4.81%, lower LoD, wider dynamic range, excellent recovery results, and good stability of the modifier compared to those for the previously reported methods validated the use of the poly(reso)/GCE for determining CLN and CFL simultaneously in various real samples.

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Section: Cyclic Voltammetric Investigation Of Cln and Cfl 231 Electro...mentioning

confidence: 99%

Potentiodynamic Poly(resorcinol)-Modified Glassy Carbon Electrode as a Voltammetric Sensor for Determining Cephalexin and Cefadroxil Simultaneously in Pharmaceutical Formulation and Biological Fluid Samples

et al. 2022

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“…Scheme 1 exhibits the principle of our proposed LDH immunosensor based on analyte‐driven catalytic reaction, as LDH associated with the glycolysis pathway oxidizes lactate to pyruvate and reduces NAD + to NADH [12]. In our detection system, MWCNTs were modified on GCE surface in order to increase surface area of the electrode followed by deposition of AuNPs enhancing the conductivity for further modification of LDH antibody [13, 14]. After LDH was captured by the antibody due to the specific recognition and binding, it catalyzed the formation of pyruvate and NADH in substrate solution, which can enhance current signal.…”

Section: Resultsmentioning

confidence: 99%

“…surface in order to increase surface area of the electrode followed by deposition of AuNPs enhancing the conductivity for further modification of LDH antibody [13,14]. After LDH was captured by the antibody due to the specific recognition and binding, it catalyzed the formation of pyruvate and NADH in substrate solution, which can enhance current signal.…”

Section: Principle Of the Immunosensormentioning

confidence: 99%

Electrochemical Immunosensor for Lactate Dehydrogenase Detection Through Analyte‐driven Catalytic Reaction on Multi‐walled Carbon Nanotubes and Gold Nanoparticle Modified Carbon Electrode

et al. 2022

Electroanalysis

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A novel electrochemical immunosensor for lactate dehydrogenase (LDH) detection was proposed based on analyte‐driven catalytic reaction by attaching LDH antibodies on multi‐walled carbon nanotubes (MWCNTs) and gold nanoparticles (AuNPs) modified glassy carbon electrodes (GCE). As LDH was captured by the antibodies on electrode surface, it catalyzed the formation of pyruvate and the reduced form of nicotinamide adenine dinucleotide (NADH), thus a sensitive electrochemical signal obtained from the above redox reaction was recorded by differential pulse voltammetry (DPV). Under optimum conditions, the developed immunosensor exhibits high sensitivity for LDH quantification ranging from 0.001 μg/mL to 0.5 μg/mL with a low detection limit at 0.39 ng/mL. This developed immunosensor reveals ideal accuracy and feasibility for LDH detection in Streptococcus uberis (S. uberis) induced bovine mammary epithelial cells (MECs) samples by comparison with conventional commercial kit, which shows remarkably application potential in diseases diagnosis.

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“…The prepared nanomaterials were then modified with glassy carbon electrodes. Finally, the developed electrodes were used to detect cephalexin in Figure 3 a [ 34 ]. The limit of detection was low: 0.22 M. The modified electrode, which was based on MWCNTs and AuNPs, showed a 7-fold higher sensitivity than that of the bare electrode.…”

Section: Nanomaterial-based Electrochemical Analysis Of Antibioticmentioning

confidence: 99%

“… ( a ) The determination of cefadroxil β-lactam antibiotic was carried out using a modified gold nanoparticle/multiwalled glassy carbon nanotube [ 34 ]. ( b ) Molecularly imprinted carbon paste electrode for furazolidone detection [ 35 ].…”

Section: Figurementioning

confidence: 99%

A Minireview for Recent Development of Nanomaterial-Based Detection of Antibiotics

Hong

Zhao

et al. 2023

Biosensors

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Antibiotics are considered a new type of organic pollutant. Antibiotic residues have become a global issue due to their harm to human health. As the use of antibiotics is increasing in human life, such as in medicine, crops, livestock, and even drinking water, the accurate analysis of antibiotics is very vital. In order to develop rapid and on-site approaches for the detection of antibiotics and the analysis of trace-level residual antibiotics, a high-sensitivity, simple, and portable solution is required. Meanwhile, the rapid nanotechnology development of a variety of nanomaterials has been achieved. In this review, nanomaterial-based techniques for antibiotic detection are discussed, and some reports that have employed combined nanomaterials with optical techniques or electrochemical techniques are highlighted.

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Electroanalysis of Cefadroxil Antibiotic at Carbon Nanotube/Gold Nanoparticle Modified Glassy Carbon Electrodes

Cited by 13 publications

References 66 publications

Potentiodynamic Poly(resorcinol)-Modified Glassy Carbon Electrode as a Voltammetric Sensor for Determining Cephalexin and Cefadroxil Simultaneously in Pharmaceutical Formulation and Biological Fluid Samples

Potentiodynamic Poly(resorcinol)-Modified Glassy Carbon Electrode as a Voltammetric Sensor for Determining Cephalexin and Cefadroxil Simultaneously in Pharmaceutical Formulation and Biological Fluid Samples

Electrochemical Immunosensor for Lactate Dehydrogenase Detection Through Analyte‐driven Catalytic Reaction on Multi‐walled Carbon Nanotubes and Gold Nanoparticle Modified Carbon Electrode

A Minireview for Recent Development of Nanomaterial-Based Detection of Antibiotics

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